ВЛИЯНИЕ КЛИНИКО-ЛАБОРАТОРНЫХ ФАКТОРОВ НА РАЗВИТИЕ ГЕМОДИНАМИЧЕСКИХ ОСЛОЖНЕНИЙ ВО ВРЕМЯ АНЕСТЕЗИИ ПРИ КАРДИОХИРУРГИЧЕСКИХ ВМЕШАТЕЛЬСТВАХ

  • Р. Э. Якубцевич УО "Гродненский государственный медицинский университет", Гродно, Беларусь https://orcid.org/0000-0002-8699-8216
  • К. О. Кротков Гродненский областной клинический кардиологический центр, Гродно, Беларусь
Ключевые слова: кардиоанестезиология, гемодинамические осложнения, клеточные маркеры, эндотелиальная дисфункция

Аннотация

Введение. В настоящее время кардиоанестезиология – одна из наиболее активно развивающихся областей современной медицины. Благодаря новым методам лечения, значительно расширился контингент пациентов, которым возможно выполнение кардиохирургического вмешательства. Основные проблемы, приводящие к гемодинамическим осложнениям, – эндотелиальная дисфункция и клеточная гипоксия. Цель. Предоставить данные о влиянии клинико-лабораторных факторов эндотелиальной дисфункции и клеточной гипоксии на развитие гемодинамических осложнений во время анестезии при кардиохирургических вмешательствах. Материал и методы. Представлен обзор и анализ литературных данных 49 источников. Результаты. Лабораторными маркерами эндотелиальной дисфункции, приводящей к развитию основных гемодинамических осложнений при сердечно-сосудистых заболеваниях, являются MPC-1, СРБ, NO, TNF-α, ИЛ-6, гомоцистеин. Выводы. Полученные данные свидетельствуют о существенном влиянии клеточных маркеров (MPC-1,
СРБ, NO, TNF-α, ИЛ-6, гомоцистеин) и клинико-лабораторных факторов эндотелиальной дисфункции не только на развитие основных заболеваний сердечно-сосудистой системы, но и их осложнений. Раннее изучение данных маркеров может улучшить анестезиологическое пособие во время проведения кардиохирургических операций, а также уменьшить осложнения в послеоперационном периоде.

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2021-09-08
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Якубцевич РЭ, Кротков КО. ВЛИЯНИЕ КЛИНИКО-ЛАБОРАТОРНЫХ ФАКТОРОВ НА РАЗВИТИЕ ГЕМОДИНАМИЧЕСКИХ ОСЛОЖНЕНИЙ ВО ВРЕМЯ АНЕСТЕЗИИ ПРИ КАРДИОХИРУРГИЧЕСКИХ ВМЕШАТЕЛЬСТВАХ. Журнал ГрГМУ (Journal GrSMU) [Интернет]. 8 сентябрь 2021 г. [цитируется по 28 ноябрь 2021 г.];19(4):367-75. доступно на: http://journal-grsmu.by/index.php/ojs/article/view/2676

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