РОЛЬ ПОЛИМОРФИЗМОВ ГЕНОВ TTN, TTN-TRUNCATION, ММР-2, ММР-3 В РАЗВИТИИ АНТРАЦИКЛИН-ИНДУЦИРОВАННОЙ КАРДИОМИОПАТИИ

  • И. А. Карпуть УО "Гродненский государственный медицинский университет", Гродно, Беларусь https://orcid.org/0000-0003-0478-9419
  • В. А. Снежицкий УО "Гродненский государственный медицинский университет", Гродно, Беларусь https://orcid.org/0000-0002-1706-1243
  • М. Н. Курбат УО "Гродненский государственный медицинский университет", Гродно, Беларусь https://orcid.org/0000-0002-8518-2450
  • А. Ю. Рубинский Гродненский областной клинический кардиологический центр, Гродно, Беларусь
  • Т. А. Смирнова Гродненская университетская клиника, Гродно, Беларусь
Ключевые слова: химиотерапия, кардиотоксичность, белок титин, матриксные металлопротеиназы

Аннотация

В обзоре рассматривается актуальная проблема кардиотоксичности химиопрепаратов. Противоопухолевые антибиотики антрациклины способны вызывать кардиомиoпатию, которая может ухудшать прогноз у онкопациентов и быть самостоятельной причиной смерти. Выявление пациентов с высоким риском кардиотоксичности – первый шаг на пути к успешной профилактике сердечной недостаточности у онкобольных. Генетическое типирование может стать эффективной мерой прогнозирования повышенного риска кардиотоксического действия антрациклинов. В обзоре проанализирована роль мутаций генов при развитии сердечной недостаточности, индуцированной химиотерапией.

Литература

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Опубликован
2021-05-15
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Карпуть ИА, Снежицкий ВА, Курбат МН, Рубинский АЮ, Смирнова ТА. РОЛЬ ПОЛИМОРФИЗМОВ ГЕНОВ TTN, TTN-TRUNCATION, ММР-2, ММР-3 В РАЗВИТИИ АНТРАЦИКЛИН-ИНДУЦИРОВАННОЙ КАРДИОМИОПАТИИ. Журнал ГрГМУ (Journal GrSMU) [Интернет]. 15 май 2021 г. [цитируется по 7 декабрь 2022 г.];19(2):135-40. доступно на: http://journal-grsmu.by/index.php/ojs/article/view/2578

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