РОЛЬ ЭНДОТЕЛИЯ В ВАЗОДИЛАТАЦИИ, ОПОСРЕДОВАННОЙ РАЗЛИЧНЫМИ ПОДТИПАМИ АДРЕНОРЕЦЕПТОРОВ

  • В. И. Козловский УО «Гродненский государственный медицинский университет»
Ключевые слова: вазодилатация, адренорецепторы, эндотелий, оксид азота

Аннотация

В настоящем обзоре проведен анализ роли эндотелия в сосудистых эффектах, развивающихся при активации различных подтипов адренорецепторов. Данные литературы свидетельствуют об участии NO и других эндотелиальных сосудорасширяющих факторов в механизмах вазодилатации, опосредованной альфа-2, бета-1, бета-2 и бета-3 адренорецепторами. Тем не менее, вклад эндотелия в вазодилататорные реакции, обусловленные адренергическими механизмами, существенно отличается в различных областях сосудистого русла.

Литература

Козловский, В.И. Эффекты, связанные с возбуждением ?2- адренорецепторов в коронарном кровообращении изолирован­ного сердца морской свинки / В.И. Козловский, С. Хлопицкий, Р.Е. Грыглевский // Журнал Гродненского государственного меди­цинского университета. - 2004. - №1. - С. 10-14.

Козловский, В.И. Коронарорасширяющие свойства пропра- нолола, опосредованные эндотелиальным оксидом азота / В. И. Козловский, С. Хлопицкий // Проблемы интеграции функций в физиологии и медицине (к 100-летнему юбилею присуждения Нобелевской премии академику И. П. Павлову): труды конферен­ции. - Минск, 2004. - С. 187-188.

Козловский, В.И. Исследование механизма коронарорас- ширяющего эффекта карведилола в изолированном сердце морс­кой свинки / В. И. Козловский, С. Хлопицкий, Р. Е. Грыглевский // Журнал Гродненского государственного медицинского универ­ситета. - 2005. - №1. - С. 56-60.

Козловский, В.И. Исследование эффектов активации бета-3 и альфа-2 адренорецепторов на модели изолированной аорты морской свинки / В.И. Козловский, В.В. Зинчук, П.Б. Станкевич, Ч.Ф. Юровский // Новости медико-биологических наук. - 2010. - №1 (принята в печать).

Козловский, В.И. Исследование роли NO в эффектах агони- стов различных подтипов адренорецепторов в коронарных сосу­дах / В.И. Козловский, В.В. Зинчук, С. Хлопицкий // Эксперимен­тальная и клиническая фармакология (принята в печать).

Akimoto, Y. Nitric oxide (NO) primarily accounts for endothelium-dependent component of beta-adrenoceptor-activated smooth muscle relaxation of mouse aorta in response to isoprenaline / Y. Akimoto, T. Horinouchi, M. Shibano [et al.] // J Smooth Muscle Res. - 2002. - Vol. 38, №4-5. - P. 87-99.

Altwegg, L.A. Nebivolol induces NO-mediated relaxations of rat small mesenteric but not of large elastic arteries / L.A. Altwegg, L.V. d'Uscio, C. Barandier [et al.] // J. Cardiovasc. Pharmacol. - 2000. - Vol. 36, №3. - P. 316-320.

Ayajiki, K. Regional difference in the response mediated by beta 1 -adrenoceptor subtype in bovine cerebral arteries / K. Ayajiki, N. Toda // J. Cereb. Blood Flow Metab. - 1992. - Vol. 12, №3. - P. 507-513.

Bea, M. L. Lack of importance of NO in beta-adrenoceptor- mediated relaxation of large epicardial canine coronary arteries / M.L. Bea, B. Ghaleh, J.F. Giudicelli, A. Berdeaux // Br. J. Pharmacol.

- 1994. - Vol. 111, №4. - P. 981-982.

Berkenboom, G. The influence of atherosclerosis on the mechanical responses of human isolated coronary arteries to substance P, isoprenaline and noradrenaline / G. Berkenboom, M. Depierreux, J. Fontaine // Br. J. Pharmacol. - 1987. - Vol. 92, №1. - P. 113-120.

Bernard, F. Study of the vasodilating activity of salbutamol on dog coronary arteries. Unexpected effects of methylene blue / F. Bernard, S. Jouquey, G. Hamon // Pharmacology. -1991. - P. 42, №5.

- P. 246-251.

Blankesteijn, W.M., Effect of NG-monomethyl-L-arginine on the beta-adrenoceptor-mediated relaxation of rat mesenteric resistance arteries / W.M. Blankesteijn, T. Thien // Life Sci. - 1993.

- Vol. 52, № 16. - P. 135-139.

Bockman, C.S. Alpha-2 adrenoceptor subtype causing nitric oxide-mediated vascular relaxation in rats / C.S. Bockman, I. Gonzalez- Cabrera, P.W. Abel // J. Pharmacol. Exp. Ther. - 1996. - Vol. 278, №3. - P. 1235-1243.

Broeders, M.A. Nebivolol: a third-generation beta-blocker that augments vascular nitric oxide release: endothelial beta(2)- adrenergic receptor-mediated nitric oxide production / M.A. Broeders, P.A. Doevendans, B.C. Bekkers [et al.] - Circulation. - 2000. - Vol. 102, №6. - P. 677-684.

Bronquard, C. Contractile and relaxant properties of rat- isolated pulmonary veins related to localization and histology / C. Bronquard, V. Maupoil, B. Arbeille [et al.] // Fundam. Clin. Pharmacol. // 2007. - Vol. 21, №1. - P. 55-65.

Bryan, R.M., Jr. Stimulation of alpha 2 adrenoceptors dilates the rat middle cerebral artery / R.M. Bryan Jr., M.Y. Eichler, M.W. Swafford [et al.] // Anesthesiology. - 1996. - Vol. 85, №1. - P. 82-90.

Carrier, G.O. Enhancement of alpha-1 and alpha-2 adrenergic agonist-induced vasoconstriction by removal of endothelium in rat aorta / G.O. Carrier, RE. White // Pharmacol. Exp. Ther. - 1985. - Vol. 232, №3. - P. 682-687.

Chang, H.Y. Role of nitric oxide in vasodilator response induced by salbutamol in rat diaphragmatic microcirculation / H.Y. Chang // Am. J. Physiol. - 1997. - Vol. 272. - P. 2173-2179.

Chlopicki, S. NO-dependent vasodilation induced by nebivolol in coronary circulation is not mediated by beta-adrenoceptors or by 5-HT1A receptors / S. Chlopicki, V. I. Kozlovski, R. J. Gryglewski. // J. Physiol. Pharmacol. - 2002. - Vol. 53, №4. - P. 615-624.

Chlopicki, S. Clonidine-induced coronary vasodilatation in isolated guinea pig heart is not mediated by endothelial alpha2 adrenoceptors / S. Chlopicki, V. I. Kozlovski, R. J. Gryglewski. // J Physiol. Pharmacol. - 2003. - Vol. 54, №4. - P. 511-521.

Cocks, T. M. Endothelium-dependent relaxation of coronary arteries by noradrenaline and serotonine / T. M. Cocks, J.A. Angus // Nature. - 1983. - Vol. 30, № 5. - P. 627-630.

Corr, L. Responses of the rabbit epicardial coronary artery to acetylcholine and adrenoceptor agonists / L. Corr, G. Burnstock, P. Poole-Wilson // Cardiovasc. Res. 1991. - Vol. 25, №3. - P. 256-262.

de Groot, A. A. Involvement of the beta3 adrenoceptor in nebivolol-induced vasorelaxation in the rat aorta / A. A. de Groot, M.J. Mathy, P.A. van Zwieten, S.L. Peters // J. Cardiovasc. Pharmacol.

- 2003. - Vol. 42. - P. 232-236.

Dohi,Y. Endothelial modulation of contractile responses in arteries from hypertensive rats / Y. Dohi, M. Kojima, K. Sato // Hypertension. - 1996. - Vol. 28, №5. - P. 732 - 737.

Evangelista, S. Effect of DL-nebivolol, its enantiomers and metabolites on the intracellular production of superoxide and nitric oxide in human endothelial cells / S. Evangelista, U. Garbin, A.F. Pasini [et al.] // Pharmacol. Res. - 2007. - Vol. 55, №4. - P. 303­309.

Feres, T. Impaired function of alpha-2 adrenoceptors in smooth muscle of mesenteric arteries from spontaneously hypertensive rats / T. Feres, A.C. Borges, E.G. Silva [et al.] // Br. J. Pharmacol. - 1998. - Vol. 125, №6. - P. 1144-1149.

Ferro, A. Activation of nitric oxide synthase by beta 2- adrenoceptors in human umbilical vein endothelium in vitro / A. Ferro, L.R. Queen, R.M. Priest [et al.] // Br. J. Pharmacol. - 1999. - Vol. 126, №8. - P. 1872-1880.

Figueroa, X.F. NO production and eNOS phosphorylation induced by epinephrine through the activation of beta-adrenoceptors / X.F. Figueroa, I. Poblete, R. Fernandez [et al.] // Am. J. Physiol. Heart Circ. Physiol. - 2009. - Vol. 297, №1. - P. 134-143.

Freissmuth, M. Cardiac ventricular beta 2-adrenoceptors in guinea-pigs and rats are localized on the coronary endothelium / M. Freissmuth, V. Hausleithner, S. Nees [et al.] // Naunyn Schmiedebergs Arch. Pharmacol. - 1986. - Vol. 334, №1. - P. 56 - 62.

Gao, Y. S. Nebivolol induces endothelium-dependent relaxations of canine coronary arteries / Y.S. Gao, T. Nagao, R.A. Bond [et al.] // J. Cardiovasc. Pharmacol. - 1991. - Vol. 17, №6. - P. 964-969.

Georgescu, A. The cellular mechanisms involved in the vasodilator effect of nebivolol on the renal artery / A. Georgescu, F. Pluteanu, M.L. Flonta [et al.] // Eur. J. Pharmacol. - 2005. - Vol. 508, №1-3. - P. 159-166.

Ghaleh, B. Endothelial modulation of beta-adrenergic dilation of large coronary arteries in conscious dogs / B. Ghaleh, M.L. Bea, J.L. Dubois-Rande [et al.] // Circulation. -1995. - Vol. 92, №9. - P. 2627-2635.

Gosgnach, W. Nebivolol induces calcium-independent signaling in endothelial cells by a possible beta-adrenergic pathway / W. Gosgnach, C. Boixel, N. Nevo [et al.] // J. Cardiovasc. Pharmacol. - 2001. - Vol. 38, №2. - P. 191-199.

Graves, J. Beta-adrenoceptor agonist mediated relaxation of rat isolated resistance arteries: a role for the endothelium and nitric oxide / J. Graves, L. Poston // Br. J. Pharmacol. - 1993. - Vol. 108, №3. - P. 631-637.

Guney, H.Z. In vitro susceptibility rhythms. II. Biological- time-dependent differences in effect of beta 1 - and beta 2-adrenergic agonists of rat aorta and influence of endothelium / H.Z. Guney, U. Hodoglugil, C. Uluoglu [et al.] // Chronobiol. Int. - 1998. - Vol. 15, №2. - P. 159-172.

Hempelmann, R.G. Endothelium-dependent noradrenaline- induced relaxation of rat isolated cerebral arteries: pharmacological characterization of receptor subtypes involved / R.G. Hempelmann, A. Ziegler // Br. J. Pharmacol. - 1993. - Vol. 110, №4. - P. 1321­1328.

Howell, R. E. Characterization of beta-adrenergic receptors in cultured human and bovine endothelial cells / R.E. Howell, S.M. Albelda, M.L. Daise, E.M. Levine // J. Appl. Physiol. - 1988. - Vol. 65, №3. - P. 1251-1257.

Huang, Y. Beta-adrenoceptor-mediated relaxation inhibited by tetrapentylammonium ions in rat mesenteric artery / Y. Huang, K.H. Kwok. // Life Sci. - 1998. - Vol. 62, №2. - P. 19-25.

Huang, Y. Role of endothelium and K+ channels in dobutamine- induced relaxation in rat mesenteric artery / Y. Huang, K.H. Kwok, N.W. Chan [et al.] // Clin. Exp. Pharmacol. Physiol. - 1998. - Vol. 25, №6. - P. 405-411.

Ikomi, F. Beta-1 and beta-2 adrenoceptors mediate smooth muscle relaxation in bovine isolated mesenteric lymphatics / F. Ikomi, Y. Kawai, T. Ohhashi // J. Pharmacol. Exp. Ther. - 1991. - Vol. 259, №1. - P. 365-370.

Kamata, K. Involvement of endothelial cells in relaxation and contraction responses of the aorta to isoproterenol in naive and streptozotocin-induced diabetic rats / K. Kamata, N. Miyata, Y. Kasuya // J. Pharmacol. Exp. Ther. - 1989. - Vol. 249, №3. - P. 890-894.

Karadas, B. Effects of formoterol and BRL 37344 on human umbilical arteries in vitro in normotensive and pre-eclamptic pregnancy / B. Karadas, T. Kaya, M. Cetin [et al.] // Vascul. Pharmacol. - 2007. - Vol. 46, №5. - P. 360-366.

Kichuk, M.R. Regulation of nitric oxide production in human coronary microvessels and the contribution of local kinin formation / M.R. Kichuk, N. Seyedi, X. Zhang [et al.] // Circulation. - 1996. - Vol. 94, №1. - P. 44-51.

Kozlovski, V.I. Effects of two beta-3 agonists, CGP 12177A and BRL 37344, on coronary flow and contractility in isolated guinea pig heart / V.I. Kozlovski, S. Chlopicki, R.J. Gryglewski // Journal of Cardiovascular Pharmacology. - 2003. - Vol. 41, №5. - P. 706-713.

Leblais, V. Beta-adrenergic relaxation in pulmonary arteries: preservation of the endothelial nitric oxide-dependent beta2 component in pulmonary hypertension / V. Leblais, E. Delannoy, F. Fresquet [et al.] // Cardiovasc. Res. - 2008. - Vol. 77, №1. - P. 202­21 0.

Lu, Z. beta-Adrenoceptors in endothelium of rabbit coronary artery and alteration in atherosclerosis / Z. Lu, P. Qu, K. Xu, C. Han // Biol. Signals. - 1995. - Vol. 4, №3. - P. 50-159.

MacDonald, A. Effects of propranolol and L-NAME on beta- adrenoceptor-mediated relaxation in rat carotid artery / A. MacDonald, M. McLean, L. MacAulay, A.M. Shaw // J. Auton. Pharmacol. - 1999.

- Vol.19, №3. - P. 145-149.

Majmudar, N.G. Contribution of nitric oxide to beta2- adrenoceptor mediated vasodilatation in human forearm arterial vasculature / N.G. Majmudar, D. Anumba, S.C. Robson, G.A. Ford // Br. J. Clin. Pharmacol. - 1999. - Vol. 47, №2. - P. 173-177.

Matsuda, H. Endothelium-mediated dilations contribute to the polarity of the arterial wall in vasomotion induced by alpha 2- adrenergic agonists / H. Matsuda, E. Kuon, J. Holtz, R. Busse // J. Cardiovasc. Pharmacol. - 1985. - Vol. 7, №4. - P. 680-688.

Matsuda, K. Unaltered endothelium-dependent modulation of contraction in the pulmonary artery of hypertensive rats / K. Matsuda, F. Sekiguchi, K. Yamamoto [et al.] // Eur. J. Pharmacol. - 2000. - Vol. 392, № 1-2. - P. 61 - 70.

McEniery, C.M. Nebivolol increases arterial distensibility in vivo / C.M. McEniery, M. Schmitt, A. Qasem [et al.] // Hypertension.

- 2004. - Vol. 44, №3. - P. 305-310.

Miller, V.M. Modulation of endothelium-derived nitric oxide in canine femoral veins / V.M. Miller, D.A. Barber // Am. J. Physiol. - 1996. - Vol. 271. - P. 668-673.

Parenti, A. Inositol phosphate metabolism and nitric-oxide synthase activity in endothelial cells are involved in the vasorelaxant activity of nebivolol / A. Parenti, S. Filippi, S. Amerini [et al.] // J. Pharmacol. Exp. Ther. - 2000. - Vol. 292, № 2. - P. 698-703.

Priest, R. M. Noradrenaline, beta-adrenoceptor mediated vasorelaxation and nitric oxide in large and small pulmonary arteries of the rat / R.M. Priest, D. Hucks, J.P. Ward // Br. J. Pharmacol. - 1997. - Vol. 122, №7. - P. 1375-1384.

Queen, L.R. Mechanisms underlying beta2-adrenoceptor- mediated nitric oxide generation by human umbilical vein endothelial cells / L.R. Queen, Y. Ji, B. Xu [et al.] // J Physiol. - 2006. - Vol. 576.

- P. 585-594.

Rozec, B. Characterization of beta3-adrenoceptors in human internal mammary artery and putative involvement in coronary artery bypass management / B. Rozec, S. Serpillon, G. Toumaniantz [et al.] // J. Am. Coll. Cardiol. - 2005. - Vol. 46, №2. - P. 351-359.

Ruan, Y. Beta adrenergic receptor stimulated prostacyclin synthesis in rabbit coronary endothelial cells is mediated by selective activation of phospholipase D: inhibition by adenosine 3"5'-cyclic monophosphate / Y. Ruan, H. Kan, K.U. Malik // J. Pharmacol. Exp. Ther. - 1997. - Vol. 281, №3. - P. 1038-1046.

Rubanyi, G. Endothelium-removal decreases relaxations of canine coronary arteries caused by beta-adrenergic agonists and adenosine / G. Rubanyi, P.M. Vanhoutte // J. Cardiovasc. Pharmacol. - 1985. - Vol. 7, №1. - P. 139-144.

Schindler, C. Mechanisms of beta-adrenergic receptor- mediated venodilation in humans / C. Schindler, D. Dobrev, M Grossmann et al. // Clin. Pharmacol. Ther. - 2004. - Vol. 75, №1. - P. 49-59.

Shimokawa, H. Natural course of the impairment of endothelium-dependent relaxations after balloon endothelium removal in porcine coronary arteries. Possible dysfunction of a pertussis toxin- sensitive G protein / H. Shimokawa, N.A. Flavahan, P.M. Vanhoutte // Circ. Res. - 1989. - Vol. 65, №3. - P. 740-753.

Steinberg, S.F. Endothelial cells contain beta adrenoceptors / S.F. Steinberg, E.A. Jaffe, J.P. Bilezikian // Naunyn Schmiedebergs Arch. Pharmacol. - 1984. - Vol. 325, №4. - P. 310-313.

Thorin, E. Nitric oxide inhibits alpha2-adrenoceptor-mediated endothelium-dependent vasodilation / E. Thorin, P.L. Huang, M.C. Fishman, J.A. Bevan // Circ Res. - 1998. - Vol. 82, № 12. - P. 1323­1329.

Toyoshima, H. Modulation of cAMP-mediated vasorelaxation by endothelial nitric oxide and basal cGMP in vascular smooth muscle / H. Toyoshima, Y. Nasa, Y. Hashizume et al. // J. Cardiovasc. Pharmacol.

- 1998. - Vol. 32, №4. - P. 543-551.

Tran Quang, T. Investigation of the different adrenoceptor targets of nebivolol enantiomers in rat thoracic aorta / T. Tran Quang, B. Rozec, L. Audigane, C. Gauthier // Br. J. Pharmacol. - 2009. - Vol. 156, №4. - P. 601-608.

Trochu, J.N. Beta 3-adrenoceptor stimulation induces vasorelaxation mediated essentially by endothelium-derived nitric oxide in rat thoracic aorta / J.N. Trochu, V. Leblais, Y. Rautureau [et al.] // Br. J. Pharmacol. - 1999. - Vol. 128, №1. - P. 69-76.

White, R.E., Enhanced relaxation response of canine coronary artery to isoproterenol and salbutamol after removal of endothelial cells / R.E. White, S.R Jolly, G.O. Carrier // Gen. Pharmacol. - 1986.

- Vol. 17, №4. - P. 497-499.

Young, M.A. Enhanced adrenergic constriction of iliac artery with removal of endothelium in conscious dogs / M.A. Young, S.F. Vatner // Am. J. Physiol. - 1986. - Vol. 250. - P. 892-897.

Zschauer, A.O. Norepinephrine-induced contraction of isolated rabbit bronchial artery: role of alpha 1 - and alpha 2- adrenoceptor activation / A.O. Zschauer, M.W. Sielczak, D.A Smith, A.J. Wanner // J. Appl. Physiol. - 1997. - Vol. 82, №6. - P. 1918­1925.




Загрузок PDF: 117
Опубликован
2015-10-26
Как цитировать
1.
Козловский ВИ. РОЛЬ ЭНДОТЕЛИЯ В ВАЗОДИЛАТАЦИИ, ОПОСРЕДОВАННОЙ РАЗЛИЧНЫМИ ПОДТИПАМИ АДРЕНОРЕЦЕПТОРОВ. Журнал ГрГМУ (Journal GrSMU) [Интернет]. 26 октябрь 2015 г. [цитируется по 12 октябрь 2024 г.];(1(29):32-5. доступно на: http://journal-grsmu.by/index.php/ojs/article/view/974

Наиболее читаемые статьи этого автора (авторов)