ВЛИЯНИЕ НАГРУЗКИ ФЕНИЛАЛАНИНОМ НА АМИНОКИСЛОТНЫЙ ПРОФИЛЬ ПЛАЗМЫ КРОВИ КРЫСЯТ
Аннотация
Исследовано содержание свободных аминокислот и их азотсодержащих метаболитов в плазме крысят через 1 ч после однократного введения фенилаланина в дозе 100 мг/кг массы. Обнаружено повышение уровней ароматических аминокислот с тенденцией снижения концентраций нейтральных аминокислот (глицин, валин, лейцин, изолейцин). На фоне нагрузки фенилаланином в организме животных выявлена быстрая наработка тирозина.Литература
Davis, A.T. Threonine metabolism of chicks fed threonine- imbalanced diets / A.T.Davis, R.E.Austic // J. Nutr. - 1982. - Vol. 112. - P. 2177-2186.
Davis,A.J. Dietary threonine imbalance alters threonine dehydrogenase activity in isolated hepatic mitochondria of chicks and rats / A.J.Davis, R.E.Austic // J. Nutr. - 1994. - Vol. 124. - P. 1667-1677.
Fagone,P. Membrane phospholipid synthesis and endoplasmic reticulum function / P.Fagone, S.Jackowski // J. Lipid Res. - 2009. - Vol. 50. - P. S311-S316.
Fugh-Berman,A. Dietary supplements and natural products as psychotherapeutic agents / A.Fugh-Berman, J.M.Cott // Psychosom. Med. - 1999. - V.61. - P. 712-728.
Harper,A.E. Amino acid imbalances, toxicities and antagonisms / A.E.Harper // Nutr. Rev. - 1956. - Vol. 14. - P. 225227.
Hyland,K. Inherited disorders affecting dopamine and serotonin: critical neurotransmitters derived from aromatic amino acids / K.Hyland // J. Nutr. - 2007. - Vol. 137. - P. 1568S-1572S.
Ip,C.C.Y. Liver polysome profiles and protein synthesis in rats fed a threonine-imbalanced diet / C.C.Y.Ip, A.E.Harper // J. Nutr. - 1974. - Vol. 104. - P. 252-263.
Keene,J.C. Dietary supplements of mixtures of indispensable amino acids lacking threonine, phenylalanine or histidine increase the activity of hepatic threonine dehydrogenase, phenylalanine hydroxylase or histidase, respectively, and prevent growth depressions in chicks caused by dietary excesses of threonine, phenylalanine, or histidine / J.C.Keene, R.E.Austic // J. Nutr. Biochem. - 2001. - Vol. 12. - P. 274-284.
Kumta,U.S., Amino acid balance and imbalance. IX. Effects of amino acid imbalance on blood amino acid pattern / U.S.Kumta, A.E.Harper // Proc. Soc. Exp. Biol. Med. - 1962. - Vol. 110. - P. 512-517.
Lartey,F.M. Phenylalanine hydroxylase activity and expression in chicks subjected to phenylalanine imbalance or phenylalanine toxicity / F.M.Lartey, R.E.Austic // Poult. Sci. - 2009. - Vol. 88. - P. 774-783.
Lu,J. Phenylalanine-pyruvate aminotransferase activity in chicks subjected to phenylalanine imbalance or phenylalanine toxicity / J.Lu, R.Austic // Poult. Sci. - 2009. - Vol. 88. - P. 2375-2381.
Matthews,D.E. An overview of phenylalanine and tyrosine kinetics in humans / D.E.Matthews // J. Nutr. - 2007. - Vol. 137. - P. 1549S-1555S.
Park,B. Changes in hepatic branched-chain -keto acid dehydrogenase activity in response to isoleucine imbalance in growing chickens / B.Park, R.E.Austic // J. Nutr. Biochem. - 1998. - Vol. 9. - P. 687-696.
Large neutral amino acids in the treatment of PKU: from theory to practice / F.J.Spronsen [et al] // J. Inherit. Metab. Dis. - 2010. - Vol. 33, N6. - P. 671-676.
Webber,W.A. Interactions of amino acids in renal transport / W.A.Webber, J.L.Brown, R.F.Pitts // Am. J. Physiol. - 1961. - Vol. 200. - P. 380-386.
Yuan,J. H. Temporal response of hepatic threonine dehydrogenase in chickens to the initial consumption of a threonine- imbalanced diet / J.H.Yuan, A.J.Davis, Austic R. E. // J. Nutr. 2000. - Vol. 130. - P. 2746-2752.
