БИОЛОГИЧЕСКИЕ МАРКЕРЫ ПОВРЕЖДЕНИЯ ГЕМАТОЭНЦЕФАЛИЧЕСКОГО БАРЬЕРА ПРИ НЕЙРОИНФЕКЦИЯХ
Аннотация
Актуальность. Состояние гематоэнцефалического барьера (ГЭБ) зависит от внешних факторов, к которым относятся возбудители нейроинфекций и от внутренней среды организма человека представленной различными структурными компонентами нейроваскулярной системы головного мозга. Цель – представить структурные и функциональные характеристики компонентов ГЭБ и основные маркеры повреждения ГЭБ при патологических состояниях и нейроинфекциях. Материал и методы. Информационный поиск проведен на доступных сайтах компьютерных баз данных MEDLINE, е-LIBRARY, Springer Link, Ebsco HOST и PubMed, по ключевым терминам, касающихся заявленных структурных и функциональных характеристик ГЭБ, отражающих повреждение и нарушение проницаемости при нейроинфекциях. Результаты. В отдельных разделах обзора содержится информация о структурно-функциональной характеристике ГЭБ, его функциях и состоянии при различной патологии центральной нервной системы. Отдельный раздел посвящен механизмам нарушения проницаемости и значению биологических маркеров в диагностике повреждения ГЭБ, среди которых, на взгляд авторов, обозначены наиболее информативные, изучение которых при нейроинфекциях наиболее оправдано. Вывод. Исследование состояния структурных компонентов нейроваскулярной системы головного мозга при нейроинфекциях является актуальным и направлено на разработку новых биологических маркеров оценки повреждения и нарушения проницаемости ГЭБ у одного пациента одновременно по показателям крови и ликвора.
Литература
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