ЛИПОПРОТЕИН(А) И АТЕРОСКЛЕРОТИЧЕСКИЕ СЕРДЕЧНО-СОСУДИСТЫЕ ЗАБОЛЕВАНИЯ: РОЛЬ И ПЕРСПЕКТИВЫ ПРИМЕНЕНИЯ РЕЗУЛЬТАТОВ ИССЛЕДОВАНИЙ

  • А. Р. Пашковский Гродненский областной клинический кардиологический центр, Гродно, Беларусь https://orcid.org/0009-0000-5144-3475
  • В. А. Снежицкий Гродненский государственный медицинский университет, Гродно, Беларусь https://orcid.org/0000-0002-1706-1243
  • А. В. Янушко Гродненский областной клинический кардиологический центр, Гродно, Беларусь
Ключевые слова: липопротеин(а), сердечно-сосудистые заболевания, атеросклероз, факторы риска

Аннотация

Липиды и частицы липопротеинов обуславливают развитие атеросклероза и определяют риск сердечно-сосудистых заболеваний. Помимо общего холестерина, липопротеинов низкой и высокой плотности (ЛПНП, ЛПВП), также другие липидные медиаторы способствуют сердечно-сосудистому риску. Липопротеин(а) (Лп(a)) – один из них. В настоящее время рекомендации и консенсусные заявления рекомендуют измерение Лп(а) у всех взрослых хотя бы один раз в жизни. Лп(а) состоит из ЛПНП-подобной частицы, в которой апобелок(а) посредством одной дисульфидной связи ковалентно связан с апобелком В100. Уровень Лп(а) – генетически обусловленная особенность. Цель. Провести анализ литературы по клиническому значению липопротеин(а) в развитии сердечно-сосудистых заболеваний. Материал и методы. Проанализировано 46 литературных источников. Выводы. Учитывая четкие литературные данные, указывающие на связь Лп(а) с сердечно-сосудистыми заболеваниями в качестве независимых факторов атерогенеза и тромбогенеза, несомненный интерес вызывает изучение роли Лп(а) в развитии сердечно-сосудистых событий.

Литература

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Опубликован
2024-11-04
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Пашковский АР, Снежицкий ВА, Янушко АВ. ЛИПОПРОТЕИН(А) И АТЕРОСКЛЕРОТИЧЕСКИЕ СЕРДЕЧНО-СОСУДИСТЫЕ ЗАБОЛЕВАНИЯ: РОЛЬ И ПЕРСПЕКТИВЫ ПРИМЕНЕНИЯ РЕЗУЛЬТАТОВ ИССЛЕДОВАНИЙ. Журнал ГрГМУ (Journal GrSMU) [Интернет]. 4 ноябрь 2024 г. [цитируется по 24 ноябрь 2024 г.];22(5):399-07. доступно на: http://journal-grsmu.by/index.php/ojs/article/view/3190