ВЛИЯНИЕ КОРВИТИНА НА КИСЛОРОДТРАНСПОРТНУЮ ФУНКЦИЮ И ГАЗОТРАНСМИТТЕРЫ КРОВИ ПРИ ИШЕМИИ- РЕПЕРФУЗИИ НИЖНЕЙ КОНЕЧНОСТИ
Аннотация
Введение. Ишемия-реперфузия нижних конечностей при атеросклерозе их артерий сопровождается нарушением кислородтранспортной функции (КТФ) и содержания газотрансмиттеров (ГТ) крови, которые нуждаются в адекватной коррекции.
Цель. Изучение влияния корвитина на показатели КТФ и ГТ монооксида азота и сероводорода в венозной крови после реваскуляризации нижней конечности при хронической атеросклеротической окклюзии поверхностной бедренной артерии (ПБА).
Материал и методы. Реваскуляризация нижних конечностей у 103 пациентов выполнялась методом петлевой эндатерэктомии из ПБА. Пациенты I группы (n=52) получали традиционное медикаментозное сопровождение, II (n=51) – корвитин. Показатели КТФК и ГТ в венозной крови нижней и верхней конечностей определялись перед операцией, на третьи и восьмые сутки после нее.
Результаты. Нарастание параметров гипероксемии, гипокапниемии и концентрации ГТ в послеоперационном периоде уменьшается при применении корвитина.
Выводы. Использование корвитина уменьшает нарушения КТФК и содержания ГТ при ишемии-реперфузии нижних конечностей.
Литература
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