РОЛЬ МУТАЦИИ ГЕНОВ ИНСУЛИНОВОГО РЕЦЕПТОРА В РАЗВИТИИ ФЕНОМЕНА ИНСУЛИНОРЕЗИСТЕНТНОСТИ
Аннотация
Механизм развития инсулинорезистентности до конца не расшифрован. Нарушения, приводящие к инсулинорезистентности, могут происходить на следующих уровнях сигнального пути инсулина: пререцепторном (аномальный инсулин), рецепторном (снижение количества или аффинности рецепторов), на уровне транспорта глюкозы (снижение количества молекул GLUT4) и пострецепторном (нарушения передачи сигнала). В статье проанализирован сигнальный путь инсулина и рассмотрено влияние мутаций генов на передачу сигнала и транспортировку глюкозы в клетку.
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