АДЕНОЗИН И Р7-ПУРИНЕРГИЧЕСКИЕ РЕЦЕПТОРЫ ЦНС
Аннотация
В прогрессивно нарастающем за последние пять лет числе публикаций, посвященных роли пуринов в ЦНС, основное внимание сфокусировано на функции аденозина. Экспериментально подтверждена роль аденозина в качестве нейротрансмиттера и нейромоду- лятора в периферической и центральной нервной системе. Идентифицирован и в значительной мере изучен специфический пуринерги- ческийрецепторный аппарат. Установлена трофическая роль аденозина в нейронах и клетках глии, например, влияние на пластические изменения, вовлеченные в процессы памяти и обучения, стимуляция коллатерального роста нервных окончаний, нейропротектор- ные свойства, а также регуляция количества клеток посредством индукции апоптоза.
Литература
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