ВЛИЯНИЕ ПОЛИМОРФИЗМА ГЕНОВ TNF-Б (G308A) И IL-10 (G- 1082A) ПРИ ИНФАРКТЕ МИОКАРДА НА ЭКСПРЕССИЮ ПРО- И ПРОТИВОВОСПАЛИТЕЛЬНЫХ ЦИТОКИНОВ
Аннотация
Значительное количество исследований посвящено поиску генетических факторов, предрасполагающих к неблагоприятному течению коронарной болезни сердца. Одно из главных направлений в этих исследованиях — изучение полиморфизма генов про- и противовоспалительных цитокинов. В статье приводятся результаты исследований по изучению ассоциаций полиморфизма генов TNF-6(G-308A) и IL-10(G-1082A) с инфарктом миокарда, и влияние данных полиморфизмов на экспрессию цитокинов.
Литература
Аллельный полиморфизм генов про- и противовоспалительных цитокинов при инфаркте миокарда в европеоидной популяции мужчин / В. И. Коненков [и др.] // Бюллетень СО РАМН. - 2006. - № 2(120). - С. 56-62.
Анализ полиморфизма трех позиций промоторного региона гена TNF-б у пациентов с ишемической болезнью сердца, нестабильной стенокардией и инфарктом миокарда / А. В. Шевченко [и др.] // Кардиология. - 2010. - № 2. - С. 9-14.
Ассоциация полиморфных маркеров генов иммунной системы с количественными признаками патогенетически значимыми для хронического вирусного гепатита / И. А. Гончарова [и др.] // Молекулярноая биология. - 2008. - № 2. - С. 242-246.
Allele frequencies of polymophisms of TNFA, IL-6, IL-10 and IFNG in an Italian Caucasian risk of population / F. Poll [et al.] // Eur. J. Immunogen. - 2002. - Vol. 29. - P. 237-240.
Altman, R. Risk factors in coronary atherosclerosis athero-inflammation: the mitting point / R. Altman// Thrombosis J. - 2003. - Vol. 1. - P. 4-14.
Arnett, D.K. Relevance of genetics and genomics for prevention and treatment of cardiovascular disease: a scientific statement from the American Heart association Council on epidemiology and prevention, the Stroke Council, and Functional genomics and Translational biology interdisciplinary working group / D. K. Arnett, A. E. Baird, R. A. Barkley // Circulation. - 2007. - Vol. 115. - P. 2878-2901.
Association of gene polymorphisms with myocardial infarction in individuals with or without conventional coronary studies/ K. Nishihama [et al.] // Ann Hum Genet. - 2006. - Vol. 70. - P. 145-169.
Association of TNF-a Promoter Polymorphism, With Septic Shock Susceptibility and Mortality / J. P. Mira [et al.] // J. Am- Med. Assoc. - 1999. - Vol. 282. - P. 561-568.
Attenuation of atherogenesis by systemic and local adenovirus mediated gene transfer of interleukin 10 in LDLr/ mice. / J. H. Von Der Thusen [et al.] // FASEB J. - 2001. - Vol. 15. - P. 2730-2732.
Candidate gene genotypes, along with conventional risk factor assessment? Improve estimation of coronary heart disease risk in healthy UK men / S. E. Humphries [et al.] // Clin Chem. - 2007. - Vol. 53. - P. 8-16.
Das, U. N. Free radicals, cytokines and nitric oxide in cardiac failure and myocardial infarction / U. N. Das // Mol. Cell Biochem. - 2000. - Vol. 215. - P. 145-152.
Differential regulation of IL-10 production by genetic and environmental factors—a twin study / E. Reuss [et al.] / / Genes Immun. - 2002. - Vol. 3. - P. 407-413.
Excessive fat accumulation is associated with the TNFa -308G/A promoter polymorphism in women but not in men / J. Hofstedt [et al.] // Diabetologia. - 2000. - Vol. 43. - P. 117-120.
Gene polymorphism in the TNF locus and the Myocardial infarction / J. Q Padovani [et al.] // Thrombosis Research. - 2000. - Vol. 100. - P. 263-269.
Hollegaard, M.V. Cutokine gene polymorphism in human disease: on-line databases, Sup, 3 / M. V. Hollegaard, J. L. Bigwell // Gen immune. - 2006. - Vol. 7. - P. 269-276.
IL10 and toll-like receptor-4 polymorphisms and the in vivo and ex vivo response to endotoxin / E. F. Schippers [et al.] // Cytokine. - 2005. - Vol. 29. - P. 215-228.
Interindividual variations in constitutive IL10 messenger RNA and protein levels and their association with genetic polymorphisms / A. Suarez [et al.] // Transplantation. - 2003. - Vol. 75. - P. 711-717.
Interleikine-10and tumor necrosis factor gene polymorphism and risk of coronary artery disease and myocardial infarction / P. M. Koch [et al.] // Atherosclerosis. - 2001. - Vol. 98. - P. 435-437.
Interleukin-1 receptor antagonist gene роlymorphism in carotid atherosclerosis / B. B. Worral [et al.] // Stroke. - 2003. - Vol. 34, № 3. - P. 790-793.
Investigating the genetic determinants of cardiovascular disease using candidate genes and meta- analysis of association risk factors / J. P. Casas [et al.] // Intern J Molec Med. - 2007. - Vol. 19. - P. 129-41.
Li, J. Enhancing antiinflammatory cytokine IL10 may be beneficial for acute coronary syndrome / J. Li, Y. Guo // Med. Hypoth. - 2005. - Vol. 65. - P. 103-106.
Plasma tumor necrosis factor and early carotid atherosclerosis in healthy middle-aged men / T. Skoog [et al.] // Eur. Heart J. - 2002. - Vol. 23. - P. 376-383.
Polymorphism in the IL10 promoter region and early markers of atherosclerosis: The cardiovascular risk in young finns study / M. Heiskanen [et al.] // Atherosclerosis. - 2010. - Vol. 208. - P. 190-196.
Raised interleukin-10 is an indicator of poor outcome and enhanced systemic inflammation in patients with acute coronary syndrome / A. Malarstig [et al.] // Heart. - 2008. - Vol. 94. - P. 724-729.
Serum level of the antiinflammatory cytokine interleukin-10 is an important prognostic determinant in patients with acute coronary syndromes / C. Heeschen [et al.] // Circulation. - 2003. - Vol. 107. - P. 2109-2114.
Serum levels of the antiinflammatory cytokine IL-10 are decreased in patients with unstable angina / D. A. Smith [et al.] // Circulation. - 2001. - Vol. 104. - P. 746-749.
Tedgui, A. Antiinflammatory mechanisms in the vascular wall / A. Tedgui, Z. Mallat // Circ. Res. - 2001. - Vol. 88. - P. 877-887.
The interleukin-10-1082 G/A polymorphism: allele frequency in different populations and functional significance / L. Rees [et al.] / Cellular And Molecular Life Science. - 2002. - Vol. 59. - P. 560-569.
The TNF6 gene g(-308)a polymorphism as a marker for myocardial infarction in type 2 diabetes mellitus / H. Reschner [et al.] // BJMG. - 2008. - №2. - Р.11-16.
Tumor necrosis factor-a -308 promoter gene polymorphism and increased tumor necrosis factor serum bioactivity in fanner's lung patients / B. M. Schaaf [et al.] // Am. J. Respir. Crit. Care Med. - 2001. -Vol. 163. - P. 379-382.
