ОСОБЕННОСТИ ПРИМЕНЕНИЯ КЛОПИДОГРЕЛЯ У БОЛЬНЫХ С ОСТРЫМ КОРОНАРНЫМ СИНДРОМОМ
Аннотация
В статье приводятся данные крупных рандомизированных клинических испытаний клопидогреля для лечения больных с острым коронарным синдромом. В большинстве исследований показан положительный клинический эффект.
Литература
Clopidogrel and Aspirin versus Aspirin Alone for the Prevention of Atherothrombotic Events/D.L. Bhatt [et al.]//N Engl J Med. -2006 -Vol. 354, N 20. -P. 1706-1717.
CAPRIE Steering Committee: A randomized, blinded, trial of clopidogrel versus aspirin in patients at risk of ischaemic events (CAPRIE)//Lancet. -1996. -Vol. 348. -P. 1329-1339.
Eriksson, P. Long-term clopidogrel therapy after percutaneous coronary intervention in PCI-CURE and CREDO: the «Emperor's New Clothes» revisited/P. Eriksson//Eur. Heart J. -2004. Vol. 25. -P. 720-722.
Garton, M. COMMIT/CCS-2 studies/M. Garton//Lancet. -2006. -Vol. 368(9536), N 19. -P.642.
Effects of pre-treatment with clopidogrel and aspirin followed by long-term therapy in patients undergoing percutaneous coronary intervention: the PCI-CURE study/S. Mehta [et al.]//Lancet. -2001. -Vol. 358. -P. 527-533.
For the CREDO Investigators. Clopidogrel for the Reduction of Events During Observation: early and sustained dual oral antiplatelet therapy following percutaneous coronary intervention: a randomised controlled trial/S.R. Steinhubl [et al.]//JAMA. -2002. -Vol. 288. -P. 2411-2420.
Clopidogrel in Unstable Angina to Prevent Recurrent Events Trial investigators. Effects of clopidogrel in addition to aspirin in patients with acute coronary syndromes without ST-segment elevation. The CURE study/S. Yusuf [et al.]//N Engl J Med. -2001. -Vol. 345. -P. 494-502.
