ИНСУЛИНИНДУЦИРОВАННЫЕ ЛИПОГИПЕРТРОФИИ: КЛИНИЧЕСКИЙ ОПЫТ
Аннотация
Липогипертрофии – это частый побочный эффект подкожной инсулинотерапии. Абсорбция инсулина из участков липогипертрофии происходит неконтролируемо, поэтому у пациентов возникают трудности с достижением компенсации углеводного обмена. Проведение ультрасонографии подкожной жировой клетчатки позволит диагностировать липогипертрофии у пациентов с сахарным диабетом в повседневной клинической практике и достичь лучшей приверженности пациентов в отношении управления диабетом путем изменения места и дозы вводимого препарата инсулина.
Литература
Volkova NI, Davidenko IYu. Lypohypertrophy in patients receiving insulin therapy: state of the art. Diabetes Mellitus. 2011;(2):86-89. edn: OXKKHZ. (Russian).
Klimontov VV, Lazarev MM, Letyagin AJu, Bulumbaeva DM, Bgatova NP. Lipodystrophy at the insulin injection sites: current trends in epidemiology, diagnostics and prevention. Diabetes Mellitus. 2020;23(2):161-173. https://doi.org/10.14341/DM12095. (Russian).
Barola A, Tiwari P, Bhansali A, Grover S, Dayal D. Insulin-Related Lipohypertrophy: Lipogenic Action or Tissue Trauma? Front Endocrinol (Lausanne). 2018;9:638. https://doi.org/10.3389/fendo.2018.00638.
Abu Ghazaleh H, Hashem R, Forbes A, Dilwayo TR, Duaso M, Sturt J, Halson-Brown S, Mulnier H. A Systematic Review of Ultrasound-Detected Lipohypertrophy in Insulin-Exposed People with Diabetes. Diabetes Ther. 2018;9(5):1741-1756. https://doi.org/10.1007/s13300-018-0472-7.
Al Ajlouni M, Abujbara M, Batieha A, Ajlouni K. Prevalence of lipohypertrophy and associated risk factors in insulin-treated patients with type 2 diabetes mellitus. Int J Endocrinol Metab. 2015;13(2):e20776. https://doi.org/10.5812/ijem.20776.
Gentile S, Guarino G, Giancaterini A, Guida P, Strollo F. A suitable palpation technique allows to identify skin lipohypertrophic lesions in insulin-treated people with diabetes. Springerplus. 2016;5:563. https://doi.org/10.1186/s40064-016-1978-y.
Volkova NI, Davidenko IYu. Clinical significance of lipohypertrophy without visual and palpable changes detected by ultrasonography of subcutaneous fat. Terapevticheskii arkhiv. 2019;91(4):62-66. https://doi.org/10.26442/00403660.2019.04.000128. https://elibrary.ru/swzzkf. (Russian).
Al Hayek AA, Robert AA, Braham RB, Al Dawish MA. Frequency of Lipohypertrophy and Associated Risk Factors in Young Patients with Type 1 Diabetes: A Cross-Sectional Study. Diabetes Ther. 2016;7(2):259-67. https://doi.org/10.1007/s13300-016-0161-3.
Gentile S, Strollo F, Ceriello A; AMD-OSDI Injection Technique Study Group. Lipodystrophy in Insulin-Treated Subjects and Other Injection-Site Skin Reactions: Are We Sure Everything is Clear? Diabetes Ther. 2016;7(3):401-9. https://doi.org/10.1007/s13300-016-0187-6.
Famulla S, Hövelmann U, Fischer A, Coester HV, Hermanski L, Kaltheuner M, Kaltheuner L, Heinemann L, Heise T, Hirsch L. Insulin Injection Into Lipohypertrophic Tissue: Blunted and More Variable Insulin Absorption and Action and Impaired Postprandial Glucose Control. Diabetes Care. 2016;39(9):1486-92. https://doi.org/10.2337/dc16-0610.
Perciun R, Mihu M. The Subcutis Ultrasound Map of Type 1 Diabetic Children Improves the Diagnosis of Local Dystrophies and Insulin Injection Technique. Pediatrics Research International Journal. 2014;2014(2014):402780. https://doi.org/10.5171/2014.402780.
Klimontov VV, Lazarev MM, Makhotin AA, Letyagin AJu, Anisimova LA, Bulumbaeva DM, Koroleva EA, Lykov AP. Insulin-induced lipohypertrophy: clinical and ultrasound characteristics. Diabetes Mellitus. 2018;21(4):255-263. https://doi.org/10.14341/DM9549. https://elibrary.ru/ykxedj. (Russian).
Deng N, Zhang X, Zhao F, Wang Y, He H. Prevalence of lipohypertrophy in insulin-treated diabetes patients: A systematic review and meta-analysis. J Diabetes Investig. 2017;9(3):536-43. https://doi.org/10.1111/jdi.12742.
Pickup JC, Yemane N, Brackenridge A, Pender S. Nonmetabolic complications of continuous subcutaneous insulin infusion: a patient survey. Diabetes Technol Ther. 2014;16(3):145-9. https://doi.org/10.1089/dia.2013.0192.
Bertuzzi F, Meneghini E, Bruschi E, Luzi L, Nichelatti M, Epis O. Ultrasound characterization of insulin induced lipohypertrophy in type 1 diabetes mellitus. J Endocrinol Invest. 2017;40(10):1107-1113. https://doi.org/10.1007/s40618-017-0675-1.
