ОПТИМИЗАЦИЯ ОПРЕДЕЛЕНИЯ МЕТАБОЛИТОВ ФЕНИЛАЛАНИНА И СВОБОДНЫХ АМИНОКИСЛОТ В МОЧЕ МЕТОДОМ ВЭЖХ ДЛЯ ИСПОЛЬЗОВАНИЯ В ТАРГЕТНОЙ МЕТАБОЛОМИКЕ У ОНКОЛОГИЧЕСКИХ ПАЦИЕНТОВ
Аннотация
Цель. Отработка метода определения в моче соединений, характеризующих метаболизм ароматических аминокислот, потенциально диагностически значимых в оценке активности злокачественного роста. Методы исследования. Высокоэффективная жидкостная хроматография. Результаты. Создана оригинальная модификация метода определения продуктов превращения фенилаланина, позволяющая оценивать их уровни в моче.
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