ЭЛИМИНАЦИЯ ВИРУСНЫХ ГЕПАТИТОВ: СОВРЕМЕННЫЕ СТРАТЕГИИ И ПРОБЛЕМНЫЕ ВОПРОСЫ

  • Н. В. Матиевская УО "Гродненский государственный медицинский университет", Гродно, Беларусь https://orcid.org/0000-0001-8492-6377
Ключевые слова: ВГС, ВГВ, диагностика, элиминация, препараты прямого противовирусного действия, вакцинопрофилактика, лечение

Аннотация

В статье рассматриваются подходы к элиминации вирусных гепатитов В и С в мире с учетом руководящих документов, разработанных Всемирной организацией здравоохранения. Представлены современное состояние и проблемные аспекты вопросов диагностики и лечения вирусных гепатитов современными противовирусными лекарственными средствами, вакцинопрофилактики вирусного гепатита В в мире и в Республике Беларусь.

Литература

World Health Organization. Global Hepatitis Report 2017 [Internet]. Geneva: WHO; 2017. 83 p. Available from: http://www.who.int/hepatitis/publications/globalhepatitisreport2017/en.

World Health Organization. Global Health Sector Strategy on Viral Hepatitis, 2016-2021 [Internet]. Geneva: WHO; 2016. 56 p. Available from: https://apps.who.int/iris/bitstream/handle/10665/246177/WHO-HIV-2016.06-eng.pdf?sequence=1.

Yushchuk ND, Zayratyants OV, Znoyko OO, Khripun AI, Dudina KR, Gudkova SB, Klimova EA, Krasnenkova SF, Zhuravleva AV, Orekhov OO, Bely PA. Bremja smertnosti ot virusnyh gepatitov B i C: metodologija ocenki i pokazateli v Moskve v 2015-2017 gg. [The burden of death from viral hepatitis B and C: assessment methodology and indicators in Moscow in 2015-2017]. Infekcionnye bolezni: novosti, mnenija, obuchenie [ Infectious diseases: News, Opinions, Training]. 2018;7(4):8-14. (Russian).

European Centre for Disease Control and Prevention (ECDC). Hepatitis B and C testing activities, needs, and priorities in the EU/EEA: ECDC technical report [Internet]. Stockholm: ECDC; 2017. 27 p. Available from: https://www.ecdc.europa.eu/sites/portal/files/documents/HepatitisBC-testing-in-EU-May2017.pdf.

Matsiyeuskaya NV. Ko-infekcija VICh/VGS: jetiologija, jepidemiologija, patogenez, klinika, diagnostika, lechenie. Grodno: GrGMU; 2013. 352 p. (Russian).

Vysotskaya VS, Volchenko AN, Kolomiets ND, Romanova ON, Glinskaya I. Vlijanie vakcinacii na jepidemicheskij process virusnogo gepatita B v Respublike Belarus. Jepidemiologija i Vakcinoprofilaktika [Èpidemiologiâ i vakcinoprofilaktika]. 2019;18(1):26-33. https://doi.org/10.31631/2073-3046-2019-18-1-26-33 (Russian).

Khantimirova LM, Kozlova TYu, Postnova EL, Shevtsov VA, Rukavishnikov AV. Retrospektivnyj analiz zabolevaemosti virusnym gepatitom B naselenija Rossijskoj Federacii s 2013 po 2017 g. v aspekte vakcinoprofilaktiki [Retrospective Analysis of Viral Hepatitis B Incidence in Russia from 2013 to 2017 in the Context of Preventive Vaccination]. Biopreparaty. Profilaktika, diagnostika, lechenie [BIOpreparations. Prevention, Diagnosis, Treatment]. 2018;18(4):225-235. https://doi.org/10.30895/2221-996X-2018-18-4-225-235. (Russian).

Krotkova EN, Tsyrkunov VM, Starchenko PV, Kuzmich IA. Voprosy optimizacii vakcinoprofilaktiki HBV-infekcii sredi detej i vzroslyh [Optimization of vaccine prophylaxis for hbv-infection among children and adults]. Gepatologija i gastrojenterologija [Hepatology and Gastroenterology]. 2017;1(1):64-69. (Russian).

Ministry of Health of the Republic of Belarus. Klinicheskij protokol "Diagnostika i lechenie pacientov (vzrosloe naselenie) s hronicheskimi virusnymi gepatitami B i C". Postanovlenie Ministerstva zdravoohranenija Respubliki Belarus № 19 (19 March, 2019) [Internet]. Nacionalnyj reestr pravovyh aktov Respubliki Belarus [National Register of Legal Acts of the Republic of Belarus]. 2019;8/34091. Available from: http://pravo.by/upload/docs/op/W21934091p_1557781200.pdf. (Russian).

Zinovich JaI, Oskirko AN, Aslamova SI, Truhanovich SM, Kljuchareva AA. Klinicheskie, instrumentalnye i morfologicheskie pokazateli hronicheskogo gepatita B u detej. In: Tsyrkunov VM, ed. Aktualnye voprosy gepatologii: jeksperimentanaja gepatologija, terapevticheskaja gepatologija, hirurgicheskaja gepatologija [Current issues of hepatology: experimental hepatology, therapeutic hepatology, surgical hepatology. Materials of the XI International Symposium of Belarusian Hepatologists; 2015 Oct 2; Grodno]. Grodno: GrSMU; 2015. p. 43-46. (Russian).

World Health Organization. Regional Office for Europe. Guidelines for the care and treatment of persons diagnosed with chronic hepatitis C virus infection (2018) [Internet]. Geneva: WHO; 2018. 100 p. Available from: http: //www.euro.who.int/data/assets/pdf_file/0006/393711/9789289053891-rus.pdf.

Matsiyeuskaya NV, Pashkovets AV, Stasyukevich AK, Malyishko NG. Informativnost immunofermentnogo analiza v diagnostike VGS-infekcii [Descriptiveness of enzyme-linked immunoadsorbent assay in diagnosis of HCV-infection]. Zhurnal Grodnenskogo gosudarstvennogo medicinskogo universiteta [Journal of the Grodno State Medical University]. 2016;3(55):79-81. (Russian).

Kompanija "Gilead" vkljuchila Belarus i Ukrainu v licenzii v sfere VICh i gepatita C [Internet]. IPCru. International Treatment Preparedness Coalition. Eastern Europe and Central Asia. Available from: https://itpcru.org/2017/08/24/kompaniya-gilead-vklyuchila-belarus-i-ukrainu-v-litsenzii-v-sfere-vich-i-gepatita-s. (Russian).

Zhavoronok SV, Gutmane VR, Znovetz TV, Yurkevich IV, Karpov IA, Mitsura VM, Voropaev EV, Soldatenko OV, Baryash TM, Anisko LA, Rogacheva TA, Sivachenko LV, Zhmurovskaya LS, Velgin SO, Yurovsky NN. Protivovirusnaja terapija hronicheskogo virusnogo gepatita C [Antiviral therapy of chronic viral hepatitis C]. Immunopatologija, allergologija, infektologija [Immunopathology, Allergology, Infectology]. 2017;2:6-14. https://doi.org/10.14427/jipai.2017.2.6 (Russian).

Danilau D. Sravnenie rezultatov lechenija lamivudinom i tenofovirom u pacientov s hronicheskim gepatitom v i cirrozom pecheni v ishode hronicheskogo gepatita B [Comparison of the Treatment Results for Chronic Hepatitis B and Hepatitis B Virus-Associated Liver Cirrhosis with Lamivudine and Tenofovir]. Recept [Recipe]. 2019;22(1):51-63. (Russian).

Litvinchuk D, Karpov I, Danilau D. Analiz rezultatov lechenija pacientov s hronicheskoj VGS-infekciej prolongirovannymi shemami sofosbuvir/ledipasvir i sofosbuvir+daklatasvi [Analysis of the Treatment Results for Chronic HCV Infection with Prolonged Antiviral Schemes Sofosbuvir/Ledipasvir and Sofosbuvir+Daclatasvir]. Klinicheskaja infektologija i parazitologija [Clinical infectology and parasitology]. 2019;8(3):364-372. (Russian).

Danilov DE, Litvinchuk DV, Vinogradova DA, Matveyenko AV, Karpov IA. Jeffektivnost lechenija hronicheskogo gepatita C lekarstvennymi sredstvami prjamogo [Efficacy of chronic hepatitis C therapy with direct-acting medicinal agents]. Zdravoochranenie [Health Care]. 2018;10:52-55. (Russian).

Danilau D. Lechenie hronicheskogo gepatita s protivovirusnymi shemami sofosbuvir/ledipasvir i sofosbuvir+daklatasvir [Treatment of chronic hepatitis C with sofosbuvir/ledipasvir and sofosbuvir+daclatasvir antiviral regimens]. Klinicheskaja infektologija i parazitologija [Clinical infectology and parasitology]. 2018;4:489-497. (Russian).

Zhavoronok SV, Gutmane VR, Baryash TM, Soldatenko OV, Znovets TV, Mitsura VM, Voropaev EV, Gasich EL, Yagovdik-Telezhnaja EN, Sivachenko LV, Anisko LA, Zhmurovskaja LS, Krapivina SV, Yurovskij NN, Yurkevich IV, Karpov IA. Rezultaty ispolzovanija sofosbuvira v kombinacii s ledipasvirom ili daklatasvirom dlja lechenija hronicheskogo gepatita C v Respublike Belarus [Results of the use of sofosbuvir in combinationwith ledipasvir or daclatasvir for chronic hepatitis C treatment in the Republic of Belarus ]. Zhurnal infektologii [Journal Infectology]. 2018;10(3):77-83. https://doi.org/10.22625/2072-6732-2018-10-3-77-83 (Russian).

Krotkova EN, Chernyak SA, Goncharov VV. Eeffektivnost terapii pacientov s hronicheskim gepatitom C lekarstvennymi preparatami prjamogo protivovirusnogo dejstvija belorusskogo proizvodstva [Efficiency of therapy of patients with chronic hepatitis C with Belarusian-made direct anti-viral drugs]. Gepatologija i gastrojenterologija [Hepatology and Gastroenterology]. 2018,2(2):207-210. (Russian).

Matsiyeuskaya NV, Skazka AE, Bohutsky MI. Efficacy of Sofosbuvir-containing regimens in patients with chronic hepatitis C. In: 4th Central and Eastern European Meeting on Viral Hepatitis and HIV [Internet]. Reviews in Antiviral Therapy & Infectious Diseases; 2018 Oct 11-12; Prague, Czech Republic. Prague, 2018; p. 45. Available from: http://regist2.virology-education.com/abstractbook/2018/abstractbook_4CEE.pdf. (Russian).

Kim SM, Song H. Hepatitis C virus infection in chronic kidney disease: paradigm shift in management. Korean Journal of Internal Medicine. 2018;33(4):670-678. https://doi.org/10.3904/kjim.2018.202

European Association for the Study of the Liver. EASL Recommendations on Treatment of Hepatitis C 2018 [Internet]. Journal of Hepatology. 2018;69(2):1-51. Available from: https://easl.eu/wp-content/uploads/2018/10/HepC-English-report.pdf.

Instrukcija po primeneniju Maviret tabletki 100mg+40mg [Internet]. Available from: https://aptekamos.ru/tovary/lekarstva/glekaprevir-pibrentasvir-14259/maviret-tabletki-100mg-40mg-90513/instrukciya. (Russian).

Parczewski M, Cielniak I, Kordek J, Cuypers L. Identifying pre-existing NS3 and NS5A resistance-associated variants and transmission chains in the Polish HIV/HCV genotype 1 epidemic: impact on prevention and treatment. Journal of Acquired Immune Deficiency Syndromes. 2018;77(5):1. https://doi.org/10.1097/QAI.0000000000001628




Загрузок PDF: 126
Опубликован
2021-06-30
Как цитировать
1.
Матиевская НВ. ЭЛИМИНАЦИЯ ВИРУСНЫХ ГЕПАТИТОВ: СОВРЕМЕННЫЕ СТРАТЕГИИ И ПРОБЛЕМНЫЕ ВОПРОСЫ. Журнал ГрГМУ (Journal GrSMU) [Интернет]. 30 июнь 2021 г. [цитируется по 21 ноябрь 2024 г.];17(6):621-9. доступно на: http://journal-grsmu.by/index.php/ojs/article/view/2637