АТФ-СИНТАЗА МИТОХОНДРИЙ
Аннотация
В настоящем обзоре собраны и проанализированы имеющиеся на сегодняшний день данные о строении и организации, расположении, механизмах работы и функциях универсального в живой природе и уникального по своим характеристикам фермента синтеза АТФ – АТФ-синтазы. Ассоциированная в димеры АТФ-синтаза митохондрий, кроме синтазной и гидролазной активности, «изгибает» внутреннюю мембрану этих органелл. С нарушениями АТФ-синтазы ассоциировано большое количество заболеваний, в том числе нейродегенеративных и митохондриальных, которые, кроме прочего, сопровождаются изменениями структуры крист митохондрий.
Литература
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