АТФ-СИНТАЗА МИТОХОНДРИЙ

  • Е. В. Узлова УО "Гродненский государственный медицинский университет", Гродно, Беларусь https://orcid.org/0000-0001-5916-4390
  • С. М. Зиматкин УО "Гродненский государственный медицинский университет", Гродно, Беларусь https://orcid.org/0000-0001-5728-2588
Ключевые слова: АТФ-синтаза, митохондрии, окислительное фосфорилирование, мозг

Аннотация

В настоящем обзоре собраны и проанализированы имеющиеся на сегодняшний день данные о строении и организации, расположении, механизмах работы и функциях универсального в живой природе и уникального по своим характеристикам фермента синтеза АТФ – АТФ-синтазы. Ассоциированная в димеры АТФ-синтаза митохондрий, кроме синтазной и гидролазной активности, «изгибает» внутреннюю мембрану этих органелл. С нарушениями АТФ-синтазы ассоциировано большое количество заболеваний, в том числе нейродегенеративных и митохондриальных, которые, кроме прочего, сопровождаются изменениями структуры крист митохондрий.

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2021-03-19
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Узлова ЕВ, Зиматкин СМ. АТФ-СИНТАЗА МИТОХОНДРИЙ. Журнал ГрГМУ (Journal GrSMU) [Интернет]. 19 март 2021 г. [цитируется по 6 октябрь 2024 г.];18(6):648-54. доступно на: http://journal-grsmu.by/index.php/ojs/article/view/2452

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