ТРИ ПУТИ РЕМЕТИЛИРОВАНИЯ ГОМОЦИСТЕИНА

  • А. В. Наумов УО «Гродненский государственный медицинский университет»
  • И. В. Данильчик УО «Гродненский государственный медицинский университет»
  • Ю. В. Сарана УО «Гродненский государственный медицинский университет»
Ключевые слова: гомоцистеин, реметилирование, бетаин-гомоцистеин-S-метилтрансфераза 2, S-метилметионин, генетический полиморфизм

Аннотация

В статье приводятся данные о ферменте BHMT2, а также его генетике. Субстратом фермента является S-метилметионин (производное метионина, которое широко представлено в растительном мире), более известный как витамин U. Проведен анализ данных о взаимосвязи генетических полиморфизмов BHMT и BHMT2 с различными заболеваниями. Приведенные данные открывают перспективы в поиске новых методов терапии.

Литература

Клинические аспекты гипергомоцистеинемии: монография / В. А. Снежицкий, В. М. Пырочкин, В. В. Спас и др. – ГрГМУ, 2011. – 292 с.

Наумов, А. В. Гомоцистеин. Медико-биологические проблемы / А. В. Наумов. – Минск: Профессиональные издания, 2013. – 312с.

Наумов, А. В. Роль процессов метилирования в этиологии и патеногенезе шизофрении / А. В. Наумов, Ю. Е. Разводовский // Журнал неврологии и психиатрии имени С. С. Корсакова. – 2009. – 109. - № 8. - С. 91 -98.

Наумов, А. В. Роль процессов метилирования в этиологии и патогнезе болезни Альцгеймера / А. В. Наумов, Ю. Е. Разводовский // Журнал неврологии и психиатрии имени С. С. Корсакова. – 2008. -108. -№ 5. - С. 99 -104.

5. An integrative genomic analysis identifies BHMT2 as a diet-dependent genetic factor protecting against acetaminophen induced liver toxicity / H. H. Liu, P. Lu, Y. Y. Guo et al. // Genome Res. – 2010. - № 20. – P. 28−35.

Associations of folate and choline metabolism gene polymorphisms with orofacial clefts / A. Mostowska, K.K. Hozyasz, P. Wojcicki et al. // J. Med. Genet. – 2010. - № 12 (47). – P.809–15.

Betaine and homocysteine concentrations in foods / A. Sakamoto, Y. Nishimura, H. Ono, N. Sakura // Pediatrics international: official journal of the Japan Pediatric Society. - 2002. - № 4 (44). – P. 409–13.

Betaine–homocysteine methyltransferase 742G>A polymorphism and risk of down syndrome offspring in a Brazilian population / M.R. Amorim , C. M. Moura , A. D. Gomes et al. // Mol. Biol. Rep. – 2013. - № 40. – P. 4685–4689.

Betainehomocysteine S-methyltransferase-2 is an S-methylmethionine-homocysteine methyltransferase / S. S. Szegedi, C. Castro, M. Koutmos, T. A. Garrow // J. Biol. Chem. – 2008. - № 283. – P. 8939−8945.

Betaine-homocysteinemethyltransferase: human liver genotype-phenotype correlation / Q. Feng, K. Kalari, B.L. Fridley at al. // Mol. Genet. Metab. – 2011. - № 2 (102). – P. 126–133.

Bhaskar, L.V.K.S. Polymorphisms in genes involved in folate metabolism and orofacial clefts / L.V.K.S. Bhaskar , J. Murthy, G.V. Babu // Archives of oral biology. – 2011. - № 56. - P.723 – 737.

Chen, C.P. Syndromes, disorders and maternal risk factors associated with neural tube defects (IV) / C.P. Chen // Taiwan J. Obstet. Gynecol. – 2008. – Vol. 47, № 2. - P. 141 – 150.

Crystal structure of rat liver betaine homocysteine S-methyltransferase reveals new oligomerization features and conformational changes upon substrate binding / B. Gonzalez,; M. A. Pajares, Martinez-Ripoll et al. // J. Mol. Biol. – 2004. - № 338. – P. 771−782.

Deletion of betaine-homocysteine S-methyltransferase in mice perturbs choline and 1-carbon metabolism, resulting in fatty liver and hepatocellular carcinomas / Y. W. Teng, M. G. Mehedint, T. A. Garrow, S. H. Zeisel // J. Biol. Chem. – 2011. - № 286. – P. 36258−36267.

Deletion of betaine-homocysteine S-methyltransferase in mice perturbs choline and 1-carbon metabolism, resulting in fatty liver and hepatocellular carcinomas / Y.W. Teng, M.G. Mehedint, T.A. Garrow, S.H. Zeisel // The Journal of biological chemistry. – 2011. - № 286(42). – P. 36258–67.

Dietary intake of S-(alpha-carboxybuty1)-DLhomocysteine induces hyperhomocysteinemia in rats / J. Strakova, K. T. Williams, S. Gupta et al. // Nutr. Res. (N.Y.). – 2010. – № 30. – P. 492−500.

Dietary S-methylmethionine, a component of foods, has choline sparing activity in chickens / N. R. Augspurger, C. S. Scherer, T. A. Garrow, D. H. Baker // J. Nutr. – 2005. - № 135. - P. 1712−1717.

Double-Headed Sulfur-Linked Amino Acids As First Inhibitors for Betaine-Homocysteine-S-Methyltransferase / J. Mládková, V. Vaněk, M. Buděšínský et al. // J Med Chem. – 2012.- №15(55). – P. 6822-31

Elevated homocysteine level in siblings of patients with schizophrenia / V. Geller, M. Friger, B.A. Sela, J. Levine // Psychiatry Res. – 2013. - № 210(3). – P. 769-72.

Elmore, C.L. The many fl avors of hyperhomocyst(e) inemia: insights from transgenic and inhibitor based mouse models of disrupted one-carbon metabolism / C.L. Elmore, R. G. Matthews // Antioxidants Redox Signaling. - 2007. - № 9. – P. 1911−1921.

Evolutionary Analyses and Natural Selection of Betaine-Homocysteine S-Methyltransferase (BHMT) and BHMT2 / R.S. Ganu, Y. Ishida, M. Koutmos et al. // Genes. – 2015. - №10.- P. 156-167.

Ganu, R.S. Molecular characterization and analysis of the porcine betaine homocysteine methyltransferase and betaine homocysteine methyltransferase-2 genes / R.S. Ganu. // Gene. – 2011. - Vol. 473, № 2. - P. 133-138.

High intakes of choline and betaine reduce breast cancer mortality in a population-based study / X. Xu, M.D. Gammon, S.H. Zeisel at al. // The FASEB Journal. – 2009. - Vol. 23. –P. 4022 – 4028.

High sodium chloride intake decreases betainehomocysteine S-methyltransferase expression in guinea pig liver and kidney / C.V. Delgado-Reyes, T.A. Garrow // Am J Physiol Regul Integr Comp Physiol.- 2005. - №288(1). – P.182–7.

Homocysteine, B vitamins, and the incidence of dementia and cognitive impairment: results from the Sacramento Area Latino Study on Aging / M.N. Haan, J.W. Miller, A.E. Aiello et al. // Am. J. Clin. Nutr. – 2007. - №85(2). – P. 511-7.

Human betaine-homocysteine methyltransferase (BHMT) and BHMT2: common gene sequence variation and functional characterization / F. Li, Q. P. Feng, C. Lee et al. // Mol. Genet. Metab. – 2008. - № 94. – P. 326−335.

Hyperhomocysteinemia – an important factor in the formation of metabolic syndrome and hypertension / A. Naumov, N. Naumova, P. Matveenko, V. Snezhitskiy // Acta Biochimica Polonica. – 2013. - Vol. 20, Suppl. 1. – P. 24.

Immunohistochemical detection of betaineho mocysteine S-methyltransferase in human, pig, and rat liver and kidney / C. Delgado-Reyes, M. Wallig, T.Garrow // Am J Physiol Regul Integr Comp Physiol.- 2001. - №393. – P.184–6.

Inhibition of betaine-homocysteine S-methyltransferase in rats causes hyperhomocysteinemia and reduces liver cystathionine beta-synthase activity and methylation capacity / J. Strakova, S. Gupta, W. D. Kruger et al. // Nutr. Res. (N.Y.). - 2011. - № 31. – P. 563−571.

Inhibition of betaine-homocysteine S-thyltransferase causes hyperhomocysteinemia in mice / M. Collinsova, J. Strakova, J. Jiracek, T. A. Garrow // J. Nutr. – 2006. - № 136. – P. 1493−1497.

Inhibitory Effect of Vitamin U (S-Methylmethionine Sulfonium Chloride) on Differentiation in 3T3-L1 Preadipocyte Cell Lines / Na Young Lee, Kui Young Park, Hye Jung Min, Kye Yong Song // Ann. Dermatol. – 2012. - № 24(1). – P. 39–44.

Mechanisms of homocysteine toxicity in humans / J. Perla-Kajan, T. Twardowski, H. Jakubowski //Amino acids. – 2007. - № 32(4). – P. 561–72.

Meta-analysis of lactation performance in dairy cows receiving supplemental dietary methionine sources or postruminal infusion of methionine / G.I. Zanton, G.R. Bowman, M. Vazquez-Anon, L.M. Rode // J Dairy Sci. – 2014. - №97(11). – P. 7085–99.

Oligomerization is required for betaine-homocysteine S-methyltransferase function / S. S. Szegedi, T. A. Garrow // Arch. Biochem. Biophys. – 2004. - №426. - P. 32−42.

Osmotic regulation of betaine homocysteine-Smethyltransferase expression in H4IIE rat hepatoma cells / C. Schafer, L. Hoffmann, K. Heldt et al. // Am J Physiol Gastrointest Liver Physiol. – 2007. - №292(4). – P. 1089–98.

Oxidative stress and homocysteine in coronary artery disease / V. Cavalca, G. Cighetti, F. Bamonti et al. // Clin Chem. – 2001. - № 47. – P. 887–892.

Plotsky, A.R. Maternal and newborn total plasma and red blood cells homocysteine and birth defects / A.R. Plotsky, A.V. Naumov, E.A. Sergey // Acta Biochemica Polonica. - 2010. - Vol.57, Suppl.4. – P. 193.

Polymorphisms located in the region containing BHMT and BHMT2 genes as maternal protective factors for orofacial clefts / A. Mostowska, K.K. Hozyasz, B. Biedziak et al. // Eur. J. Oral. Sci. – 2010. - № 4 (118). – P.325–32.

Sequestration of toxic oligomers by HspB1 as a cytoprotective mechanism / J. Ojha , G. Masilamoni , D. Dunlap et al. / Molecular and cellular biology. – 2011. - № 31(15). – P. 3146–57.

The Photoprotective Effect of S-Methylmethionine Sulfonium in Skin / W.S. Kim , H.M. Seo , W.K. Kim et al. // Int. J. Mo.l Sci. – 2015. - № 28. – P. 17088-99.

Uncovering the human methyltransferasome. / T.C. Petrossian, S.G. Clarke // Molecular & cellular proteomics: MCP. – 2011. - №10(1). – P. 110.

Yoo, J.H. Elevated levels of plasma homocyst(e)ine and asymmetric dimethylarginine in elderly patients with stroke / J.H. Yoo, S.C. Lee // Atherosclerosis. – 2001. - № 158. – P. 425–430.




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2016-08-09
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Наумов АВ, Данильчик ИВ, Сарана ЮВ. ТРИ ПУТИ РЕМЕТИЛИРОВАНИЯ ГОМОЦИСТЕИНА. Журнал ГрГМУ (Journal GrSMU) [Интернет]. 9 август 2016 г. [цитируется по 12 октябрь 2024 г.];(2(54):27-2. доступно на: http://journal-grsmu.by/index.php/ojs/article/view/1931

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