РОЛЬ МАГНИЯ В ПАТОГЕНЕЗЕ ДЕПРЕССИВНЫХ РАССТРОЙСТВ, НЕКОТОРЫХ КОМОРБИДНЫХ ЗАБОЛЕВАНИЙ И СПОСОБЫ ИХ КОРРЕКЦИИ
Аннотация
В обзоре представлены новейшие результаты мировых исследований, касающиеся физиологии магния в организме человека, а также значения магния в патогенезе депрессивных расстройств, сердечно-сосудистых заболеваний и сахарного диабета. Предложен эксклюзивный метод коррекции дефицита магния при помощи разработанного авторами суплемента Оптинерв. Намечены дальнейшие пути более детального исследования молекулярных механизмов добавок магния в качестве суплемента, как мультицентровое международное исследование.
Литература
Бегма, А. Н. Коррекция метаболических нарушений у пациентов сахарным диабетом в лечении дистальной полинейропатии / А. Н. Бегма, И. В. Бегма // Трудный пациент. - 2012. - T. 10. - № 4. - С. 33-37.
Говорин, А. В. Препараты магния при заболеваниях сердечно-сосудистой системы / А. В. Говорин, А. П. Филёв // Актуальные вопросы клинической фармакологии. - 2012. - № 8. - С. 463-468.
Aarts, M. M. TRPM7 and ischemic CNS injury / M. M. Aarts, M. Tymianski // Neuroscientist. - 2005. - № 11(2). - P. 116-123.
Abaamrane, L. Long-term administration of magnesium after acoustic trauma caused by gunshot noise in guinea pigs / L. Abaamrane [et al.] // Hear Res. - 2009. - Vol. 247. - P. 137-145.
Altura, B.M. Low extracellular magnesium ions induce lipid peroxidation and activation of nuclear factor-kappa B in canine cerebral vascular smooth muscle: possible relation to traumatic brain injury and strokes / B. M. Altura [et al.] // Neurosci Lett. - 2003. - Vol. 341. - № 3. - P. 189-192.
Altura, B. M. Role of brain [Mg2+] in alcohol-induced hemorrhagic stroke in a rat model: a 31P-NMR in vivo study / B. M. Altura [et al.] // Alcohol. - 1995. - № 12. - P. 131-136.
Altura, B. M. Short-term magnesium deficiency upregulates sphingomyelin synthase and p53 in cardiovascular tissues and cells: relevance to the de novo synthesis of ceramide / B. M. Altura [et al.] // Am J Physiol. Heart and Circulatory physiology. - 2010. - Vol. 299. - № 6. - P. 2046-2055.
Altura, B. M. Short-term Mg deficiency upregulates proteinkinase C isoforms in cardiovascular tissues and cells; relation to NF-kB, cytokines, ceramide salvage sphingolipid pathway and PKC-zeta: hypothesis and review / B.M. Altura [et al.] // Intern J Clin Exp Med. - 2014. - № 7. - P. 1-21.
Amyard, N. Brain catecholamines, serotonin and their metabolites in mice selected for low (MGL) and high (MGH) blood magnesium levels / N.Amyard [et al.] // Magnes Res. - 1995. - № 8. - P. 5-9.
Banki, C. M. Aminergic studies and cerebrospinal fluid cations in suicide / C. M. Banki, M. Arató, C. D. Kilts // Ann N Y Acad Sci. - 1986. - Vol. 487. - P. 221-230.
Banki, C. M. Cerebrospinal fluid magnesium and calcium related to amine metabolites, diagnosis, and suicide attempts / C. M. Banki [et al.] // Biol Psychiatry. - 1985. - Vol. 20. - № 2. - P. 163-171.
Bara, M. Potassium, magnesium and membranes. Review of present status and new findings / M. Bara, A. Guiet- Bara // Magnesium. - 1984. - № 3. - P. 215-225.
Barbagallo, M. Magnesium and aging / M. Barbagallo, L. J. Dominguez // Curr Pharm Des. - 2010. - Vol. 16. - № 7. - P. 832-839.
Barragán-Rodríguez, L. Efficacy and safety of oral magnesium supplementation in the treatment of depression in the elderly with type 2 diabetes: a randomized, equivalent trial / L. Barragán-Rodríguez, M. Rodríguez-Morán, F. Guerrero- Romero // Magnes Res. – 2008. - Vol. 21. - № 4. - P. 218-223.
Bear, M. F. Neurotransmitter Systems / M. F. Bear, B. W. Connors, M. A. // Paradiso In: Neuroscience Exploring the brain, 2nd ed. - Baltimore MD, Lippincot Williams and Wilkins, 2001. - P. 131-162.
Berman, R. M. Antidepressant effects of ketamine in depressed patients / R. M. Berman [et al.] // Biol Psychiatry. - 2000. - Vol. 47. - № 4. - P. 351-354.
Billard, J. M. Ageing, hippocampal synaptic activity and magnesium / J. M. Billard // Magnes Res. - 2006. - Vol. 19. - № 3. - P. 199-215.
Blaylock, R. L. Food additive excitotoxins and degenerative brain disorders / R. L. Blaylock // Medical Sentinel. - 1999. - № 4. - P. 212-214.
Caddell, J. Plasma catecholamines in acute magnesium deficiency in weanling rats / J. Caddell [et al.] // J Nutr. - 1986. - Vol. 116. - № 10. - P. 1896-1901.
Calderon, R.L. Draft for review and comments. Water hardness and cardiovascular disease: A review of epidemiological studies 1957-79 / R. L. Calderon, G. F. Craun // Rolling Revision of the WHO Guidelines for Drinking-Water Quality. - World Health Organization, August 2004. - 18 p.
Carafoli, E. Calcium-a universal carrier of biological signals / E. Carafoli // FEBS J. - 2005. - Vol. 272. - № 5. - P. 1073-1089.
Chaudhary, D. P. Implications of magnesium deficiency in type 2 diabetes: a review / D.P. Chaudhary, R. Sharma, D. Bansal // Biol Trace Elem Res. - 2010. - Vol. 134. - P. 119-129.
Cox, I. M. Red blood cell magnesium and chronic fatigue syndrome / I. M. Cox, M. J. Campbell, D. Dowson // Lancet. - 1991. - Vol. 337 (8744). - P. 757-760.
Cratty, M. S. N-methyl-D-aspartate (NMDA)-mediated corticotropin-releasing factor (CRF) release in cultured rat amygdala neurons / M. S. Cratty, D.L. Birkle // Peptides. – 1999. - Vol. 20. - № 1. - P. 93-100.
Dasgupta, A. Hypomagnesemia in type 2 diabetes mellitus/ A. Dasgupta, D. Sarma, U.K. Saikia // Indian J Endocrinol Metab. – 2012. - Vol. 16. - № 5. - P. 1000–1003.
Dayas, C. V. Effects of chronic oestrogen replacement on stress-induced activation of hypothalamic-pituitary-adrenal axis control pathways / C.V. Dayas [et al.] // J Neuroendocrinol. - 2000. - Vol. 12. - № 8. - P. 784-794.
Dong, J.F. Magnesium maintains endothelial integrity, up-regulates proteolysis of ultra-large von Willebrand factor, and reduces platelet aggregation under flow conditions / J. F. Dong [et al.] // Thromb Haemost. - 2008. - Vol. 99. - № 3. - P. 586-593.
Eby, G.A. Rapid recovery from major depression using magnesium treatment/ G. A. Eby, K. L. Eby // Med Hypotheses. - 2006. - Vol. 67. - № 2. - P. 362-370.
Enya, M. Depressive state and paresthesia dramatically improved by intravenous MgSO4 in Gitelman’s syndrome / M. Enya [et al.] // Intern Med. - 2004. - Vol. 43. - № 5. - P. 410-414.
Fekadu, A. The Maudsley Staging Method for treatment-resistant depression: prediction of longer-term outcome and persistence of symptoms / A. Fekadu [et al.] // J Clin Psychiatry. - 2009. - Vol. 70. - № 7. - P. 952-957.
Fekadu, A. A multidimensional tool to quantify treatment resistance in depression: the Maudsley staging method / A. Fekadu [et al.] // J Clin Psychiatry. - 2009. - Vol.70. - № 2. - P. 177-184.
Fekadu, A. What happens to patients with treatment-resistant depression? A systematic review of medium to long term outcome studies / A.Fekadu [et al.] // J Affect Disord. - 2009. - Vol. 116. - № 1-2. - P. 4-11.
Franz, K. B. A functional biological marker is needed for diagnosing magnesium deficiency / K. B. Franz // J Am Coll Nutr. – 2004. - Vol. 23. - P. 738-741.
Grubbs, R. D. Magnesium as a regulatory cation: criteria and evaluation / R. D. Grubbs, M.E. Maguire // Magnesium. - 1987. - Vol. 6. - № 3. - P. 113-127.
Gьnther, T. Regulation of intracellular magnesium by Mg2+ efflux / T. Gьnther, J. Vormann, R. Fцrster // Biochem Biophys Res Commun. - 1984. - Vol. 119. - P. 124-131.
Henrotte, J. G. Mice selected for low and high blood magnesium levels: a new model for stress studies / J. G. Henrotte [et al.] // Physiol Behav. - 1997. – Vol. 61. - № 5. - P. 653-658.
Iosifescu, D. V. An open study of triiodothyronine augmentation of selective serotonin reuptake inhibitors in treatment-resistant major depressive disorder / D. V. Iosifescu [et al.] // J Clin Psychiatry. - 2005. - Vol. 66. - № 8. - P. 1038- 1042.
Iotti, S. Inorganic phosphate is transported into mitochondria in the absence of ATP biosynthesis: an in vivo 31P NMR study in the human skeletal muscle / S. Iotti [et al.] // Biochem Biophys Res Commun. - 1996. - Vol. 225. - P. 191-194.
Jшrgensen, H. S. Studies on the neuroendocrine role of serotonin / H. S. Jшrgensen/ / Dan Med Bull. - 2007. - Vol. 54. - № 4. - P. 266-288.
Kandal, E. R. Synaptic integration / E.R. Kandal, J. H.Schwarz, T. M. Jessel // In: Essentials of neural science and behaviour. - Stamford, Appleton & Lange, 1995. - P. 219-241.
Khan, A. M. Low serum magnesium and the development of atrial fibrillation in the community: the Framingham Heart Study / A. M. Khan [et al.] // Circulation. - 2013. - Vol. 127. - P. 33-38.
Kundu, D. Serum magnesium levels in patients with diabetic retinopathy / D. Kundu [et al.] // J Nat Sci Biol Med. - 2013. - Vol. 4. - № 1. - P. 113–116.
Langley, W. F. Central nervous system magnesium deficiency / W. F. Langley, D. Mann // Arch Intern Med. - 1991. - Vol. 151. - P. 593-596
Lapik, I. A. Assessment of efficiency of dietotherapy with addition of a vitamin-mineral complex in patients with diabetes mellitus type 2 / I.A. Lapik [et al.] // Vopr Pitan. - 2014. - Vol. 83. - № 3. - P. 74-81.
Levine, J. High serum and cerebrospinal fluid Ca/ Mg ratio in recently hospitalized acutely depressed patients / J. Levine [et al.] // Neuropsychobiology. – 1999. - Vol. 39. - № 2. - P. 63-70.
Lipton, S.A. Excitatory amino acids as a final common pathway for neurologic disorders / S.A. Lipton, P.A. Rosenberg // N Engl J Med. - 1994. - Vol. 330. - № 9. - P. 613-622.
Machado-Vieira, R. Ketamine and the next generation of antidepressants with a rapid onset of action / R. Machado- Vieira [et al.] // Pharmacol Ther. - 2009. - Vol. 123. - № 2. - P. 143-150.
Magalhaes, A.C. CRF receptor 1 regulates anxiety behavior via sensitization of 5-HT2 receptor signaling / A. C. Magalhaes [et al.] // Nat Neurosci. - 2010. - Vol. 13. - № 5. - P. 622-629.
Mark, L.P. Pictorial review of glutamate excitotoxicity: fundamental concepts for neuroimaging / L.P. Mark [et al.] // Am J Neuroradiol. - 2001. - Vol. 22. - P. 1813-1824.
McMenimen, K. A. Probing the Mg2+ blockade site of an N-methyl-D-aspartate (NMDA) receptor with unnatural amino acid mutagenesis / K.A. McMenimen [et al.] // ACS Chem Biol. - 2006. - Vol. 1. - № 4. - P. 227-234.
Mizoguchi, K. Persistent depressive state after chronic stress in rats is accompanied by HPA axis dysregulation and reduced prefrontal dopaminergic neurotransmission / K. Mizoguchi [et al.] // Pharmacol Biochem Behav. - 2008. - Vol. 91. - № 1. - P. 170-175.
Murck, H. Magnesium and affective disorders / H. Murck // Nutr Neurosci. - 2002. - Vol. 5. - № 6. - P. 375-389.
Nierenberg, A. A. Residual symptoms after remission of major depressive disorder with citalopram and risk of relapse: a STAR*D report / A.A. Nierenberg [et al.] // Psychol Med. – 2010. – Vol. 40. - № 1. - P. 41-50.
Nowak, G. Magnesium and Glutamate interaction in depression and antidepressant therapy / G. Nowak [et al.] // Biological Psychiatry. - 2010. - Vol. 67. - P. 195.
Phelps, L. E. Family history of alcohol dependence and initial antidepressant response to an N-methyl-D-aspartate antagonist / L.E. Phelps [et al.] // Biol Psychiatry. - 2009. - Vol. 65. - № 2. - P. 181-184.
Pittaluga, A. Somatostatin potentiates NMDA receptor function via activation of InsP(3) receptors and PKC leading to removal of the Mg(2+) block without depolarization / A. Pittaluga, A. Bonfanti, M. Raiteri // Br J Pharmacol. - 2000. - Vol. 130. - № 3. - P. 557-566.
Popkin, B. M. Global nutrition dynamics: the world is shifting rapidly toward a diet linked with noncommunicable diseases / B. M. Popkin // Am J Clin Nutr. - 2006. - Vol. 84. - № 2. - P. 289-298.
Qu, X. Magnesium and the risk of cardiovascular events: a meta-analysis of prospective cohort studies / X. Qu [et al.] // PLoS One. - 2013. - Vol. 8. № 3. - P. e57720.
Rayssiguier, Y. Magnesium deficiency and metabolic syndrome: stress and inflammation may reflect calcium activation / Y. Rayssiguier [et al.] // Magnes Res. - 2010. - Vol. 23. - № 2. - P. 73–80.
Rego, A. C. Mitochondrial dysfunction and reactive oxygen species in excitotoxicity and apoptosis: implications for the pathogenesis of neurodegenerative diseases / A. C. Rego, C. R. Oliveira // Neurochem Res. - 2003. - Vol. 28. - № 10. - P. 1563-1574.
Rodraguez, M. Magnesium its role in CKD / M. Rodrнguez // Nefrologia: publicacion oficial de la Sociedad Espanola Nefrologia. - 2013. - Vol. 33. - № 3. - P. 389-399.
Rosanoff, A. Suboptimal magnesium status in the United States: are the health consequences underestimated? / A. Rosanoff, C. M. Weaver, R. K. Rude // Nutr Rev. - 2012. - Vol. 70. - № 3. - P. 153–164.
Sapolsky, R. M. Stress the aging brain and the mechanisms of neuron death / R.M. Sapolsky. - Cambridge, MA, A. Bradford Book, the MIT Press, 1992. - 192 p.
Saris, N. E. Magnesium. An update on physiological, clinical and analytical aspects / N. E. Saris [et al.] // Clin Chim Acta. - 2000. - Vol. 294. - № 1-2. - P. 1-26.
Sartori, S. B. Magnesium deficiency induces anxiety and HPA axis dysregulation: modulation by therapeutic drug treatment / S. B. Sartori [et al.] // Neuropharmacology. - 2012. - Vol. 62. - № 1. - P. 304-312.
Schmitz, C. Regulation of vertebrate cellular Mg2+ homeostasis by TRPM7 / C. Schmitz [et al.] // Cell. - 2003. - Vol. 114. - № 2. - P. 191-200.
Seelig, M.S. Consequences of magnesium deficiency on the enhancement of stress reactions; preventive and therapeutic implications (a review) / M. S. Seelig // J Am Coll Nutr. - 1994. - Vol. 13. - № 5. - P. 429-446.
Soma, M. Effects of low magnesium diet on the vascular prostaglandin and fatty acid metabolism in rats / M. Soma [et al.] // Prostaglandins. - 1988. - Vol. 36. - № 4. - P. 431-441.
Sontia, B. Role of magnesium in hypertension / B. Sontia, R. M. Touyz // Arch Biochem Biophys. - 2007. - Vol. 458. - № 1. - P. 33-39.
Szewczyk, B. Antidepressant activity of zinc and magnesium in view of the current hypotheses of antidepressant action / B. Szewczyk [et al.] // Pharmacol Rep. - 2008. - Vol. 60. - № 5. - P. 588-589.
Tietz, N. W. Clinical Guide to Laboratory Tests / N. W. Tietz. - 3rd Edition WB Saunders Company, Philadelphia, PA, 1995. - 374 p.
Topf, J. M. Hypomagnesemia and hypermagnesemia / J. M. Topf, P. T. Murray // Rev Endocr Metab Disord. - 2003. - Vol. 4. - P. 195–206.
Turgut, F. Magnesium supplementation helps to improve carotid intima media thickness in patients on haemodialysis / F. Turgut [et al.] // Intern. Urology and Nephrology. - 2008. - Vol. 40. - № 4. - P. 1075-1082.
Vink, R. Decline in intracellular free Mg2+ is associated with irreversible tissue injury after brain trauma / R. Vink [et al.] // J Biol Chem. - 1988. - Vol. 263. - № 2. - P. 757-761.
Weglicki, W. B. Cytokines, neuropeptides, and reperfusion injury during magnesium deficiency / W. B. Weglicki [et al.] // Ann N Y Acad Sci. -1994. - Vol. 17. - № 723. - P. 246-257.
Whyte, K.F. Adrenergic control of plasma magnesium in man / K. F. Whyte [et al.] // Clin Sci (Lond). - 1987. - Vol. 72. - № 1. - P. 135-138.
Wolf, M. Interaction of proteinkinase C with membranes is regulated by Ca2+, phorbol esters, and ATP / M. Wolf, P. Cuatrecasas, N. Sahyoun // J Biol Chem. – 1985. - Vol. 260. - № 29. - P. 15718-15722.
Wolf, F.I. Magnesium deficiency affects mammary epithelial cell proliferation: involvement of oxidative stress / F. I. Wolf [et al.] // Nutr Cancer. - 2009. - Vol. 61. - № 1. - P. 131-136.
World Health Report. Changing history annex table 3: burden of disease in DALYs by cause, sex and mortality stratum in WHO regions estimates for 2002. - Geneva: The World Health Organization, 2004.
Yasui, M. Effects of low calcium and magnesium dietary intake on the central nervous system tissues of rats and calcium-magnesium related disorders in the amyotrophic lateral sclerosis focus in the Kii Peninsula of Japan / M. Yasui, K. Ota, M. Yoshida // Magnes Res. - 1997. - Vol. 10. - № 1. - P. 39-50.
Zarate, C. A. A randomized trial of an N-methyl-D-aspartate antagonist in treatment-resistant major depression / C. A. Zarate [et al.] // Arch Gen Psychiatry. - 2006. - Vol. 63. - № 8. - P. 856-864.
