ПРОГНОСТИЧЕСКИЕ БИОМАРКЕРЫ ОСТРОГО ПОЧЕЧНОГО ПОВРЕЖДЕНИЯ

М. В.  Урбанович

doi:10.25298/2221-8785-2026-24-2-140-144

М. В. Урбанович Гродненский государственный медицинский университет, Гродно, Беларусь https://orcid.org/0000-0002-6479-6648

DOI: https://doi.org/10.25298/2221-8785-2026-24-2-140-144

Ключевые слова: острое повреждение почек, биомаркеры, цистатин С, липокалин, ассоциированный с желатиназой нейтрофилов, NGAL, молекула повреждения почек 1, KIM-1, TIMP-2, связывающий инсулино- подобный фактор роста 7, печеночная форма белка,, L-FABP, остеопонтин, подокаликсин, аннексин 5, тканевой фактор роста

Аннотация

Острое почечное повреждение – это гетерогенный тяжелый синдром с высоким риском летальности, который потенциально обратим при своевременной диагностике и лечении. Особое внимание уделяется прогнозированию и ранней диагностике повреждения почечной функции. Новые биомаркеры имеют важную роль в выявлении нарушений у групп высокого риска. Значение каждого из них и их комбинаций позволяют по-новому взглянуть на диагностическую тактику при заболевании почек.

Литература

Singh R, Watchorn JC, Zarbock A, Forni LG. Prognostic Biomarkers and AKI: Potential to Enhance the Identification of Post-Operative Patients at Risk of Loss of Renal Function. Res Rep Urol. 2024;16:65-78. https://doi.org/10.2147/RRU.S385856.

Korabelnikov DI, Magomedaliev MO. Modern biomarkers of acute kidney injury. Farmakoekonomika. Modern Pharmacoeconomics and Pharmacoepidemiology. 2023;16(1):87-104. https://doi.org/10.17749/20704909/farmakoekonomika.2023.171. https://elibrary.ru/imgxie. (Russian).

Yan QW, Yang Q, Mody N, Graham TE, Hsu CH, Xu Z, Houstis NE, Kahn BB, Rosen ED. The adipokine lipocalin 2 is regulated by obesity and promotes insulin resistance. Diabetes. 2007;56(10):2533-40. https://doi.org/10.2337/db07-0007.

Mori K, Lee HT, Rapoport D, Drexler IR, Foster K, Yang J, Schmidt-Ott KM, Chen X, Li JY, Weiss S, Mishra J, Cheema FH, Markowitz G, Suganami T, Sawai K, Mukoyama M, Kunis C, D'Agati V, Devarajan P, Barasch J. Endocytic delivery of lipocalin-siderophore-iron complex rescues the kidney from ischemia-reperfusion injury. J Clin Invest. 2005;115(3):610-621. https://doi.org/10.1172/JCI23056.

Hang CC, Yang J, Wang S, Li CS, Tang ZR. Evaluation of serum neutrophil gelatinase-associated lipocalin in predicting acute kidney injury in critically ill patients. J Int Med Res. 2017;45(3):1231-1244. https://doi.org/10.1177/0300060517709199.

Poston JT, Koyner JL. Sepsis associated acute kidney injury. BMJ. 2019;364:k4891. https://doi.org/10.1136/bmj.k4891.

Soto K, Coelho S, Rodrigues B, Martins H, Frade F, Lopes S, Cunha L, Papoila AL, Devarajan P. Cystatin C as a marker of AKI in the emergency department. Clin J Am Soc Nephrol. 2010;5(10):1745-54. https://doi.org/10.2215/CJN.00690110.

Nejat M, Pickering JW, Walker RJ, Westhuyzen J, Shaw GM, Frampton CM, Endre ZH. Urinary cystatin C is diagnostic of AKI and sepsis, and predicts mortality in the intensive care unit. Crit Care. 2010;14(3): R85. https://doi.org/10.1186/cc9014.

Lees JS, Rutherford E, Stevens KI, Chen DC, Scherzer R, Estrella MM, Sullivan MK, Ebert N, Mark PB, Shlipak MG. Assessment of Cystatin C Level for Risk Stratification in Adults With Chronic Kidney Disease. JAMA Netw Open. 2022;5(10):e2238300. https://doi.org/10.1001/jamanetworkopen.2022.38300.

Yin C, Wang N. Kidney injury molecule-1 in kidney disease. Renal Failure. 2016;38(10):1567-1573. https://doi.org/10.1080/0886022X.2016.1193816.

Zhang PL, Rothblum LI, Han WK, Blasick TM, Potdar S, Bonventre JV. KIM-1 expression in transplant biopsies is a sensitive measure of cell injury. Kidney Int. 2008;73(5):608-14. https://doi.org/10.1038/sj.ki.5002697.

Anandkumar DG, Dheerendra PC, Vellakampadi D, Ramanathan G. Kidney injury molecule-1; is it a predictive marker for renal diseases? J Nephropharmacol. 2023;12(2):e10572. https://doi.org/10.34172/npj.2023.10572.

Wetz AJ, Richardt EM, Wand S, Kunze N, Schotola H, Quintel M, Bräuer A, Moerer O. Quantification of urinary TIMP-2 and IGFBP-7: an adequate diagnostic test to predict acute kidney injury after cardiac surgery? Crit Care. 2015;19(1):3. https://doi.org/10.1186/s13054-014-0717-4.

Gocze I, Koch M, Renner P, Zeman F, Graf BM, Dahlke MH, Nerlich M, Schlitt HJ, Kellum JA, Bein T. Urinary biomarkers TIMP-2 and IGFBP7 early predict acute kidney injury after major surgery. PLoS One. 2015;10(3):e0120863. https://doi.org/10.1371/journal.pone.0120863.

Chiang TH, Yo CH, Lee GH, Mathew A, Sugaya T, Li WY, Lee CC. Accuracy of Liver-Type Fatty Acid-Binding Protein in Predicting Acute Kidney Injury: A Meta-Analysis. J Appl Lab Med. 2022;7(2):421-436. https://doi.org/10.1093/jalm/jfab092.

Gavrić A, Kališnik JM. Novel biomarkers for early diagnosis of acute kidney injury after cardiac surgery in adults. Kardiochir Torakochirurgia Pol. 2016;13(1):31-8. https://doi.org/10.5114/kitp.2016.58962.

Sinha SK, Mellody M, Carpio MB, Damoiseaux R, Nicholas SB. Osteopontin as a Biomarker in Chronic Kidney Disease. Biomedicines. 2023;11(5):1356. https://doi.org/10.3390/biomedicines11051356.

Sekulic M, Pichler Sekulic S. A compendium of urinary biomarkers indicative of glomerular podocytopathy. Patholog Res Int. 2013;2013:782395. https://doi.org/10.1155/2013/782395.

Jing J. The Relevance, Predictability, and Utility of Annexin A5 for Human Physiopathology. Int J Mol Sci. 2024;25(5):2865. https://doi.org/10.3390/ijms25052865.

Gewin LS. Transforming Growth Factor-β in the Acute Kidney Injury to Chronic Kidney Disease Transition. Nephron. 2019;143(3):154-157. https://doi.org/10.1159/000500093.