БАРЬЕРНЫЕ СТРУКТУРЫ ЦЕНТРАЛЬНОЙ НЕРВНОЙ СИСТЕМЫ. ЧАСТЬ 2: ИНТРАВЕНТРИКУЛЯРНАЯ И ИНТРАТЕКАЛЬНАЯ АНТИБАКТЕРИАЛЬНАЯ ТЕРАПИЯ
Аннотация
В связи с увеличением числа инвазивных методов лечения и мониторинга при нейротравме наблюдается рост числа нейроинфекций. Вторая часть обзора посвящена оценке факторов, влияющих на концентрацию антибиотика в цереброспинальной жидкости. Описаны случаи интравентрикулярного и интратекального
введения антибиотиков.
Литература
Sunwoo J, Shin H, Lee H.S, Moon J, Lee S.T, Jung K, Park K, Jung K, Kim M, Lee S. K, Chu K. A hospital-based study on etiology and prognosis of bacterial meningitis in adults. Sci Rep. 2021;11(1):6028. https://doi.org/10.1038/s41598-021-85382-4.
Van de Beek D, de Gans J, Spanjaard L, Weisfelt M, Reitsma J, Vermeulen M. Clinical features and prognostic factors in adults with bacterial meningitis. N Engl J Med. 2004;351(18):1849-1859. https://doi.org/10.1056/NEJMoa040845.
Pollay, M. Transport mechanisms in the choroid plexus. Fed. Proc. 1974;33:2064-2069.
Van de Beek D, Brouwer MC, Thwaites GE, Tunkel AR. Advances in treatment of bacterial meningitis. Lancet. 2012;380(9854):1693-1702. https://doi.org/10.1016/S0140-6736(12)61186-6.
Andes DR, Craig WA. Pharmacokinetics and pharmacodynamics of antibiotics in meningitis. Infect Dis Clin N Am. 1999;13(3):595-618. https://doi.org/10.1016/s0891-5520(05)70096-9.
Quagliarello VJ, Ma A, Stukenbrok H, Palade GE. Ultrastructural localization of albumin transport across the cerebral microvasculature during experimental meningitis in the rat. J Exp Med. 1991;174(3):657-672. https://doi.org/10.1084/jem.174.3.657.
Scheld WM, Dacey RG, Winn HR, Welsh JE, Jane JA, Sande MA. Cerebrospinal fluid outflow resistance in rabbits with experimental meningitis. Alterations with penicillin and methylprednisolone. J Clin Invest. 1980;66(2):243-253. https://doi.org/10.1172/JCI109850.
von Wedel-Parlow M, Wolte P, Galla HJ. Regulation of major efflux transporters under inflammatory conditions at the blood-brain barrier in vitro. J Neurochem. 2009;111(1):111-118. https://doi.org/10.1111/j.1471-4159.2009.06305.x.
Thea D, Barza M. Use of antibacterial agents in infections of the central nervous system. Infect Dis Clin North Am. 1989;3(3):553-570.
El Zahar NM, Sutton JM, Bartlett MG. Assessment of brain-to-blood drug distribution using liquid chromatography. Biomed Chromatogr. 2021;35(7):e5123. https://doi.org/10.1002/bmc.5123.
Ullah S, Beer R, Fuhr U, Taubert M, Zeitlinger M, Kratzer A, Dorn C, Arshad U, Kofler M, Helbok R. Brain Exposure to Piperacillin in Acute Hemorrhagic Stroke Patients Assessed by Cerebral Microdialysis and Population Pharmacokinetics. Neurocrit Care. 2020;33(3):740-748. https://doi.org/10.1007/s12028-020-00947-x.
Novak AR, Krsak M, Kiser TH, Neumann RT, Cava Prado L, Molina KC, Mueller SW. Pharmacokinetic Evaluation of Cefazolin in the Cerebrospinal Fluid of Critically Ill Patients. Open Forum Infect Dis. 2022;9(2):ofab649. https://doi.org/10.1093/ofid/ofab649.
Le Turnier P, Gregoire M, Deslandes G, Lakhal K, Deschanvres C, Lecomte R, Talarmin JP, Dubée V, Bellouard R, Boutoille D, Leroy A-G, Gaborit BJ. Should we reconsider cefazolin for treating staphylococcal meningitis? A retrospective analysis of cefazolin and cloxacillin cerebrospinal fluid levels in patients treated for staphylococcal meningitis. Clin Microbiol Infect. 2020;26(10):1415.e1. https://doi.org/10.1016/j.cmi.2020.04.046.
Andes DR, Craig WA. Pharmacokinetics and pharmacodynamics of antibiotics in meningitis. Infect Dis Clin N Am. 1999;13(3):595-618. https://doi.org/10.1016/s0891-5520(05)70096-9.
Le Turnier P, El Helali N, Guilhaumou R, Pilmis B, Revest M, Velly LJ, Leroy AG, Duval X, Lemaitre F, Gregoire M. CSF concentration of cefotaxime in adult patients with pneumococcal meningitis: A multicentre retrospective study. J Antimicrob Chemother. 2021;76(9):2352-2355. https://doi.org/10.1093/jac/dkab191.
Wang J, Wang Q, Zhao L, Shi G, Zhou J. Blood-brain barrier penetration of cefepime after neurosurgery. Chin Med J (Engl). 2007;120(13):1176-1178.
Helfer VE, Zavascki AP, Zeitlinger M, de Araújo, BV, Dalla Costa T. Population Pharmacokinetic Modeling and Probability of Target Attainment of Ceftaroline in Brain and Soft Tissues. Antimicrob Agents Chemother. 2022;66(9):e00741-22. https://doi.org/10.1128/aac.00741-22.
Kerz T, von Loewenich FD, Roberts J, Neulen A, Ringel F. Cerebrospinal fluid penetration of very high-dose meropenem: a case report. Ann Clin Microbiol Antimicrob. 2018;17(1):47. https://doi.org/10.1186/s12941-018-0299-0.
Roehr AC, Frey OR, Vetter-Kerkhoff C, Thon N, Hope W, Briegel J, Huge V. Cerebrospinal fluid penetration of meropenem in neurocritical care patients with proven or suspected ventriculitis: a prospective observational study. Crit Care. 2016;20(1):343. https://doi.org/10.1186/s13054-016-1523-y.
Cunha BA, Cunha CB. Pharmacokinetic considerations in selecting optimal antibiotic therapy for Mycoplasma pneumoniae encephalitis. Eur J Clin Microbiol Infect Dis. 2019;38(4):631-635. https://doi.org/10.1007/s10096-018-03448-0.
Kumta N, Roberts JA, Lipman J, Wong WT, Joynt GM, Cotta MO. A Systematic Review of Studies Reporting Antibiotic Pharmacokinetic Data in the Cerebrospinal Fluid of Critically Ill Patients with Uninflamed Meninges. Antimicrob Agents Chemother. 2020;65(1):e01998-20. https://doi.org/10.1128/AAC.01998-20.
Pea F, Pavan F, Nascimben E, Benetton C, Scotton PG, Vaglia A, Furlanut M. Levofloxacin disposition in cerebrospinal fluid in patients with external ventriculostomy. Antimicrob Agents Chemother. 2003;47(10):3104-3108. https://doi.org/10.1128/aac.47.10.3104-3108.2003.
Alffenaar JWC, van Altena R. Bokkerink HJ, Luijckx GJ, van Soolingen D, Aarnoutse RE, van der Werf TS. Pharmacokinetics of moxifloxacin in cerebrospinal fluid and plasma in patients with tuberculous meningitis. Clin Infect Dis. 2009;49(7):1080-1082. https://doi.org/10.1086/605576.
Beach JE, Perrott J, Turgeon RD, Ensom MH. Penetration of vancomycin into the cerebrospinal fluid: a systematic review. Clin Pharmacokinet. 2017;56(12):1479-1490. https://doi.org/10.1007/s40262-017-0548-y.
Viaggi B, Paolo AD, Danesi R, Polillo M, Ciofi L, Del Tacca M, Malacarne P. Linezolid in the central nervous system: comparison between cerebrospinal fluid and plasma pharmacokinetics. Scand J Infect Dis. 2011;43(9):721-727. https://doi.org/10.3109/00365548.2011.582140.
Myrianthefs P, Markantonis SL, Vlachos K, Anagnostaki M, Boutzouka E, Panidis D, Baltopoulos G. Serum and cerebrospinal fluid concentrations of linezolid in neurosurgical patients. Antimicrob Agents Chemother. 2006;50(12):3971-3976. https://doi.org/10.1128/AAC.00051-06.
Ceylan B, Arslan F, Sipahi OR, Sunbul M, Ormen B, Hakyemez İN, Turunc T, Yıldız Y, Karsen H, Karagoz G, Tekin R, Hizarci B, Turhan V, Senol S, Oztoprak N, Yılmaz M, Ozdemir K, Mermer S, Kokoglu OF, Mert A. Variables determining mortality in patients with Acinetobacter baumannii meningitis/ventriculitis treated with intrathecal colistin. Clin Neurol Neurosurg. 2017;153:43-49. https://doi.org/10.1016/j.clineuro.2016.12.006.
Tunkel AR, Hasbun R, Bhimraj A, Byers K, Kaplan SL, Scheld WM, van de Beek D, Bleck TP, Garton HJL, Zunt JR. Infectious Diseases Society of America's Clinical Practice Guidelines for Healthcare-Associated Ventriculitis and Meningitis. Clin Infect Dis. 2017;64(6):e34-e65. https://doi.org/10.1093/cid/ciw861.
Li X, Sun S, Ling X, Chen K, Wang Q, Zhao Z. Plasma and cerebrospinal fluid population pharmacokinetics of vancomycin in postoperative neurosurgical patients after combined intravenous and intraventricular administration. Eur J Clin Pharmacol. 2017;73(12):1599-1607. https://doi.org/10.1007/s00228-017-2313-4.
Shah SS, Ohlsson A, Shah VS. Intraventricular antibiotics for bacterial meningitis in neonates. Cochrane Database Syst Rev. 2012;7:CD004496. https://doi.org/10.1002/14651858.CD004496.pub3.
Cairns I, Duthie ES. Intrathecal streptomycin in meningitis; clinical trial in tuberculous, coliform, and other infections. Lancet. 1946;2(6414):153-155. https://doi.org/10.1016/s0140-6736(46)90728-3.
Tängdén T, Enblad P, Ullberg M, Sjölin J. Neurosurgical gram-negative bacillary ventriculitis and meningitis: a retrospective study evaluating the efficacy of intraventricular gentamicin therapy in 31 consecutive cases. Clin Infect Dis. 2011;52(11):1310-136. https://doi.org/10.1093/cid/cir197.
LeBras M, Chow I, Mabasa V, Ensom M. Systematic Review of Efficacy, Pharmacokinetics, and Administration of Intraventricular Aminoglycosides in Adults. Neurocrit Care. 2016;25(3):492-507. https://doi.org/10.1007/s12028-016-0269-3.
Imberti R, Cusato M, Accetta G, Marino V, Procaccio F, Del Gaudio A, Iotti GA, Regazzi M. Pharmacokinetics of colistin in cerebrospinal fluid after intraventricular administration of colistin methanesulfonate. Antimicrob Agents Chemother. 2012;56:4416-4421. https://doi.org/10.1128/AAC.00231-12.
Kasiakou S, Rafailidis P, Liaropoulos K, Falagas M. Cure of post-traumatic recurrent multiresistant gram-negative rod meningitis with intraventricular colistin. J Infect. 2005;50(4):348-352. https://doi.org/10.1016/j.jinf.2004.05.008.
Van de Beek D. Drake JM, Tunkel AR. Nosocomial bacterial meningitis. N Engl J Med. 2010;362(2):146-154. https://doi.org/10.1056/NEJMra0804573.
Karen Ng, Mabasa VH, Chow I, Ensom MH. Systematic review of efficacy, pharmacokinetics, and administration of intraventricular vancomycin in adults. Neurocrit Care. 2014;20(1):15-71. https://doi.org/10.1007/s12028-012-9784-z.
Takechi K, Ishikawa T, Kamei C. Epileptogenic activity induced by teicoplanin and effects of some antiepileptics in mice. J Pharmacol Sci. 2008;107(4):428-433. https://doi.org/10.1254/jphs.08111FP.
Cruciani M, Navarra A, Perri GD, Andreoni M, Danzi M, Concia E, Bassetti D. Evaluation of intraventricular teicoplanin for the treatment of neurosurgical shunt infections. Clin Infect Dis. 1992;15(2):285-289. https://doi.org/10.1093/clinids/15.2.285.
Haddad N, Carr M, Balian S, Lannin J, Kim Y, Toth C, Jarvis J. The Blood–Brain Barrier and Pharmacokinetic/Pharmacodynamic Optimization of Antibiotics for the Treatment of Central Nervous System Infections in Adults. Antibiotics (Basel). 2022;11(12):1843. https://doi.org/10.3390/antibiotics11121843.
Lich B, Conner A, Burks J, Glenn C, Sughrue M. Intrathecal/Intraventricular Linezolid in Multidrug-Resistant Enterococcus faecalis Ventriculitis. J Neurol Surg Rep. 2016;77:e160-e161. https://doi.org/10.1055/s-0036-1593439.
Erritouni M, Ktaich N, Rahal J, Figueroa D, Nieto J, Urban C, Mariano N, Eisinger F, AbayevJ, Nicolau D, Rubin D, Raifu M, Segal-Maurer S. Use of daptomycin for the treatment of methicillin-resistant coagulase-negative staphylococcal ventriculitis. Case Rep Med. 2012;2012:593578. https://doi.org/10.1155/2012/593578.
Mueller S, Kiser TH, Anderson TA, Neumann RT. Intraventricular daptomycin and intravenous linezolid for the treatment of external ventricular-drain-associated ventriculitis due to vancomycin-resistant Enterococcus faecium. Ann Pharmacother. 2012;46(12):e35. https://doi.org/10.1345/aph.1R412.
Rodvold K, Gotfried M, Cwik M, Korth-Bradley J, Dukart G, Ellis-Grosse E. Serum, tissue and body fluid concentrations of tigecycline after a single 100 mg dose. J Antimicrob Chemother. 2006;58(6):1221-1229. https://doi.org/10.1093/jac/dkl403.
Deng ZW, Wang J, Qiu CF, Yang Y, Shi ZH, Zhou JL. A case report of intraventricular and intrathecal tigecycline infusions for an extensively drug-resistant intracranial Acinetobacter baumannii infection. Medicine. 2019;98:e15139. https://doi.org/10.1097/MD.0000000000015139.
Long W, Yuan J, Liu J, Wu M, Chen X, Peng G, Wu C, Zhang C, Wang X, Zhao W, Liu Q. Multidrug Resistant Brain Abscess Due to Acinetobacter baumannii Ventriculitis Cleared by Intraventricular and Intravenous Tigecycline Therapy: A Case Report and Review of Literature. Front Neurol. 2018;9:518. https://doi.org/10.3389/fneur.2018.00518.
Soto-Hernández J, Soto-Ramírez A, Pérez-Neri I, Angeles-Morales V, Cárdenas G, Barradas V. Multidrug-resistant Klebsiella oxytoca ventriculitis, successfully treated with intraventricular tigecycline: A case report. Clin Neurol Neurosurg. 2020;188:105592. https://doi.org/10.1016/j.clineuro.2019.105592.
Li L, Zheng W, Shi S. Spinal arachnoiditis followed by intrathecal tigecycline therapy for central nervous system infection by extremely drug-resistant Acinetobacter baumannii. J Int Med Res. 2020;48(7):0300060520920405. https://doi.org/10.1177/0300060520920405.
