УНИВЕРСАЛЬНЫЕ ПРИНЦИПЫ БАКТЕРИАЛЬНОЙ КОММУНИКАЦИИ

  • Т. В. Артюх Гомельский государственный медицинский университет, Гомель, Беларусь; Гродненский государственный медицинский университет, Гродно, Беларусь https://orcid.org/0000-0001-7368-0623
  • Е. А. Сидорович Гродненский государственный медицинский университет, Гродно, Беларусь https://orcid.org/0000-0001-6829-447X
  • Д. В. Тапальский Гомельский государственный медицинский университет, Гомель, Беларусь https://orcid.org/0000-0002-9484-7848
Ключевые слова: чувство кворума, сигнальные молекулы, рецепторы, экспрессия генов, подавление кворума

Аннотация

В статье представлена актуальная информация о феномене межклеточной коммуникации бактерий, ее роли в экспрессии генов вирулентности, в частности, распространении устойчивости к антибиотикам. Выделены базовые принципы функционирования кворума, присущие всем известным на сегодняшний день системам бактериальной коммуникации. Проанализированы основные сигнальные молекулы (аутоиндукторы) внутривидовой, межвидовой, эпинефриновой и пептидной связи. Оценена роль блокирования информационной связи (сигнальных молекул) между бактериями в качестве дополнительной стратегии против бактерий с экстремальной и полной антибиотикорезистентностью.

Литература

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Опубликован
2023-11-03
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Артюх ТВ, Сидорович ЕА, Тапальский ДВ. УНИВЕРСАЛЬНЫЕ ПРИНЦИПЫ БАКТЕРИАЛЬНОЙ КОММУНИКАЦИИ. Журнал ГрГМУ (Journal GrSMU) [Интернет]. 3 ноябрь 2023 г. [цитируется по 5 октябрь 2024 г.];21(5):453-9. доступно на: http://journal-grsmu.by/index.php/ojs/article/view/3089