ФУНКЦИОНАЛЬНОЕ СОСТОЯНИЕ ЭНДОТЕЛИЯ СОСУДОВ ПРИ ГИПЕРГОМОЦИСТЕИНЕМИИ У ДЕТЕЙ С АРТЕРИАЛЬНОЙ ГИПЕРТЕНЗИЕЙ
Аннотация
Введение. Гомоцистеин – серосодержащая аминокислота, обладающая способностью оказывать повреждающее действие на эндотелий сосудов, являясь независимым фактором риска развития сердечно-сосудистой патологии. Цель: оценить функциональное состояние эндотелия сосудов при гипергомоцистеинемии у детей с артериальной гипертензией. Материал и методы. Обследованы 111 детей в возрасте от 14 до 18 лет. Все пациенты были разделены на 3 группы: 1 группу (n=51) составили дети с артериальной гипертензией, 2 группу (n=30) – с высоким нормальным артериальным давлением, 3 группу – 30 детей из групп периодического диспансерного наблюдения. Содержание гомоцистеина определяли в плазме крови методом высокоэффективной жидкостной хроматографии с флуоресцентной детекцией по методике B. M. Gilfix в модификации А. В. Наумова с соавторами. Результаты. Концентрация гомоцистеина в плазме крови возрастает у пациентов с высоким нормальным артериальным давлением и артериальной гипертензией по сравнению со здоровыми детьми. Патологическое снижение эндотелий-зависимой вазодилатации сопровождается увеличением концентрации гомоцистеина в плазме крови.
Литература
Ghantous CM, Kamareddine L, Farhat R, Zouein FA, Mondello S, Kobeissy F, Zeidan A. Advances in Cardiovascular Biomarker Discovery. Biomedicines. 2020;8(12):552. https://doi.org/10.3390/biomedicines8120552.
Richards AM. Future biomarkers in cardiology: my favourites. European Heart Journal. 2018;20(Suppl G):37G- 44G. https://doi.org/10.1093/eurheartj/suy023.
Parsanathan R, Jain SK. Novel Invasive and Noninvasive Cardiac-Specific Biomarkers in Obesity and Cardiovascular Diseases. Metab Syndr Relat Disord. 2020;18(1):10-30. https://doi.org/10.1089/met.2019.0073.
Snezhitskiy VA, Pyrochkin VМ, Spas VV, Doroshenko EM, Egorova TYu, Mironchik EV, Naumov AV, Yackubtsevich RE, Zukhovitskaya EV, Plotskiy AR, Pyrochkin АV, Yanushko TV, Valadzko YS, Pitsko DV, Predko VА, Deshko MS. Klinicheskie aspekty gipergomocisteinemii. Grodno: GrGMU; 2011. 292 p. edn: RZFMPP. (Russian).
Panasiuk OV, Mahiliavets EV, Naumov AV, Kapytski AV. Analysis of the effect of revascularization on the amino acid pool and determination of its role in the development of postoperative complications among the patients with lower limb arterial diseases. Military medicine. 2022;2(63):63-74. https://doi.org/10.51922/2074-5044.2022.2.63. https://elibrary.ru/vamkvx. (Russian).
Naumov AV, Razvodovsky YuE. Rol processov metilirovaniya v etiologii i patogeneze bolezni Alcgejmera. S.S. Korsakov journal of neurology and psychiatry. 2008;108(5):99-104. edn: ISJMDJ. (Russian).
Spirina NN, Spirin NN, Kiseleva EV, Dubchenko EA, Boyko AN. Homocysteine and markers of endothelial dysfunction in multiple sclerosis. S.S. Korsakov journal of neurology and psychiatry. 2021;121(7-2):90-93. https://doi.org/10.17116/jnevro202112107290. https://elibrary.ru/ikqojx. (Russian).
Myslivets MG, Naumov AV, Paramonova NS. Role of homocysteine in the development of juvenile rheumatoid arthritis. Journal of the Grodno state medical university. 2017;15(2):144-148. edn: ZDIPZD. (Russian).
Głuszek J, Wierzowiecka M, Niklas K, Niklas A. The importance of homocysteine in the development of cardiovascular complications in patients with rheumatoid arthritis. Reumatologia. 2020;58(5):282-288. https://doi.org/10.5114/reum.2020.99732.
Koniukh EA. Uroven gomocisteina i funkcionalnoe sostojanie jendotelija pri glomerulonefritah u detej. Maternal and child health. 2011;2(18):38-41. edn: ONYYBD. (Russian).
Perna AF, Ingrosso D. Homocysteine and chronic kidney disease: an ongoing narrative. J Nephrol. 2019;32(5):673-675. https://doi.org/10.1007/s40620-019-00622-1.
Dai C, Fei Y, Li J, Shi Y, Yang X. A Novel Review of Homocysteine and Pregnancy Complications. Biomed Res Int. 2021;2021:6652231. https://doi.org/10.1155/2021/6652231.
Rubini E, Snoek KM, Schoenmakers S, Willemsen SP, Sinclair KD, Rousian M, Steegers-Theunissen RPM. First Trimester Maternal Homocysteine and Embryonic and Fetal Growth: The Rotterdam Periconception Cohort. Nutrients. 2022;14(6):1129. https://doi.org/10.3390/nu14061129.
Alsahli S, Al Anazi A, Al Hatlani MM, Kashgari A, Al Sufiani F, Alfadhel M, Al Mutairi F. Severe Crohn’s Disease Manifestations in a Child with Cystathionine β-Synthase Deficiency. ACG Case Rep J. 2018;5:e93. https://doi.org/10.14309/crj.2018.93.
Vasiliev AG, Morozova KV, Brus TV, Zabezhinskij MM, Kravcova AA, Balashov LD, Asilieva AV, Pyurveev SS, Kosova AN. The role of homocystein metabolic disorders in pathological processes. Russian biomedical research. 2022;7(1):44-59. https://doi.org/10.56871/1453.2022.70.70.007. https://elibrary.ru/qefgqf. (Russian).
Evsiutina EP, Dinikina YV, Belogurova MB, Aleksandrovich YS. Prevention of toxicity in chemotherapy with high doses of methotrexate in children. Pediatrician. 2019;10(2):89-98. https://doi.org/10.17816/PED10289-98. https://elibrary.ru/hacqbf. (Russian).
Plotskiy AR, Egorova TYu, Naumov AV. Possibilities of prognosis and diagnosis of congenital birth defects on the basis of homocysteine level in blood plasma of pregnant women. Journal of the Grodno state medical university. 2009;(1):56-58. edn: QBFKAH (Russian).
Malik RA, Lone MR, Ahmed A, Koul KA, Malla RR. Maternal hyperhomocysteinemia and congenital heart defects: A prospective case control study in Indian population. Indian Heart J. 2017;69(1):17-19. https://doi.org/10.1016/j.ihj.2016.07.014.
Keda LN, Naumov AV, Smirnov VYu. Possibilities for prediction of congenital fetal malformations and chromosomal abnormalities based on the determination of the levels of free amino acids and their nitrogen-containing derivatives in blood plasma of pregnant women. Problems of health and ecology. 2020;3(65):152-158. edn: CXUXEP (Russian).
Fouda EM, Wahba NS, Elsharawy AIM, Ishak SR. Serum homocysteine level in pediatric patients with COVID-19 and its correlation with the disease severity. Pediatr Pulmonol. 2022;57(7):1701-1708. https://doi.org/10.1002/ppul.25920.
Carpenè G, Negrini D, Henry BM, Montagnana M, Lippi G. Homocysteine in coronavirus disease (COVID-19): a systematic literature review. Diagnosis. 2022;9(3):306-310. https://doi.org/10.1515/dx-2022-0042.
Naumov AV. Gomocistein. Mediko-biologicheskie problemy. Minsk: Professional’nye izdanija; 2013. 311 p. (Russian).
Naumau AV, Danilchyk IV, Sarana YuV. Three ways of homocysteine remethylation. Journal of the Grodno state medical university. 2016;(2):27-32. edn: WIMEYT. (Russian).
de Oliveira Leite L, Costa Dias Pitangueira J, Ferreira Damascena N, Ribas de Farias Costa P. Homocysteine levels and cardiovascular risk factors in children and adolescents: systematic review and meta-analysis. Nutr Rev. 2021;79(9):1067-1078. https://doi.org/10.1093/nutrit/nuaa116.
Naumov AV, Matveenko PA, Doroshenko EM, Snezhitskiy VA. The level of total plasma homocysteine in adolescents from rural area of Belarus and its correction. Acta Biochemica Polonica. 2009;56(S3):198. edn:YMJDMA.
Zhang Z, Gu X, Fang X, Tang Z, Guan S, Liu H, Wu X, Wang C, Zhao Y. Homocysteine and the Risk of Cardiovascular Events and All-Cause Death in Elderly Population: A Community-Based Prospective CohortStudy. Ther Clin Risk Manag. 2020;16:471-481. https://doi.org/10.2147/TCRM.S239496.
McCully KS. Homocysteine Metabolism, Atherosclerosis, and Diseases of Aging. Comprehensive Physiology. 2015;6(1):471-505. https://doi.org/10.1002/cphy.c150021.
Chistiakov DA, Melnichenko AA, Orekhov AN, Bobryshev YV. Paraoxonase and atherosclerosis-related cardiovascular diseases. Biochimie. 2017;132:19-27. https://doi.org/10.1016/j.biochi.2016.10.010.
Arab ZN, Khayatan D, Razavi SM, Zare K, Kheradkhah E, Momtaz S, Ferretti G, Bacchetti T, Sathyapalan T, Emami SA, Abdolghaffari AH, Sahebkar A. Phytochemicals as Modulators of Paraoxonase-1 in Health and Diseases. Antioxidants (Basel). 2022;11(7):1273. https://doi.org/10.3390/antiox11071273.
Gonchar MA, Konovalova NV. Homocysteine levels in the blood serum of adolescents with hypertension. Child’s health. 2013;3(46):22-26. edn: QYUMEX. (Russian).
Vorobjov AP, Frolov AV, Melnikova OP. Kompjuternyj reograf “Impekard M”. Metodika primenenija. Minsk; 2007. 52 p. (Russian).
Gilfix BM, Blank DW, Rosenblatt DS. Novel reductant for determination of total plasma homocysteine. Clin Chem. 1997;43(4):687-8.
Naumov AV, Doroshenko EM. Opredelenie gomocisteina metodom VJeZhH s predkolonochnoj derivatizaciej v mikroobiemah biologicheskih zhidkostej. In: Egorov VV, Gulevich AL, Nazarov VA, editors. Analitika RB - 2010. Sbornik tezisov dokladov Respublikanskoj nauchnoj konferencii po analiticheskoj himii s mezhdunarodnym uchastiem, posvjashhaetsja 100-letiju so dnja rozhdenija G.L. Starobinca; 2010 Maj 14-15; Minsk. Minsk; 2010. p. 138. (Russian).
