СОСТАВ ДУКТАЛЬНОГО СЕКРЕТА ПОДЖЕЛУДОЧНОЙ ЖЕЛЕЗЫ ПРИ ХРОНИЧЕСКИХ ПАНКРЕАТИТАХ АЛКОГОЛЬНОЙ ЭТИОЛОГИИ
Аннотация
Цель обзора – представить анализ современных научных сведений об изменении состава дуктального секрета поджелудочной железы при хроническом алкогольном панкреатите. Показано, что токсическое воздействие алкоголя на клеточном уровне проявляется прежде всего недостаточной секрецией воды и карбонатов дуктулоцитами мелких протоков. Рассмотрена решающая роль дисфункции CFTR каналов в этих нарушениях. Обсуждены возможные механизмы участия трипсина, лактоферрина, литостатина и кальция в процессах преципитации и камнеобразования.
Литература
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