РЕЖИМЫ НЕТРАДИЦИОННОГО ФРАКЦИОНИРОВАНИЯ В ЛУЧЕВОЙ ТЕРАПИИ РАКА ГОЛОВЫ И ШЕИ

  • Л. Б. Пархоменко Белорусская медицинская академия последипломного образования, Минск, Беларусь https://orcid.org/0000-0002-2832-0124
Ключевые слова: рак органов головы и шеи, лучевая терапия, гиперфракционирование, ускоренное фракционирование

Аннотация

Цель обзора – анализ и обобщение литературных данных о роли нетрадиционного фракционирования дозы излучения при лучевом лечении рака органов головы и шеи. Проанализировано 46 англоязычных источников с описанием радиобиологически обоснованных режимов нетрадиционного фракционирования и подтверждением их эффективности по сравнению с конвенциональной лучевой терапией в клинических исследованиях.
Результаты приведенных исследований свидетельствуют о наибольшей пользе при применении гиперфракционирования и умеренно ускоренного фракционирования дозы излучения у пациентов с плоскоклеточным раком органов головы и шеи.

Литература

Adelstein DJ, Li Y, Adams GL, Wagner H, Kish JA, Ensley JF, Schuller DE, Forastiere AA. An intergroup phase III comparison of standard radiation therapy and two schedules of concurrent chemoradiotherapy in patients with unresectable squamous cell head and neck cancer. J. Clin. Oncol. 2003;21(1):92-98. https://doi.org/10.1200/JCO.2003.01.008

Huguenin P, Beer KT, Allal A, Rufibach K, Friedli C, Davis JB, Pestalozzi B, Schmid S, Thoni A, Ozsahin M, Bernier J, Topfer M, Kann R, Meier UR, Thum P, Bieri S, Notter M, Lombriser N, Glanzmann C. Concomitant cisplatin significantly improves locoregional control in advanced head and neck cancers treated with hyperfractionated radiotherapy. J. Clin. Oncol. 2004;22(23):4665-4673. https://doi.org/10.1200/JCO.2004.12.193

Forastiere AA, Goepfert H, Maor M, Pajak TF, Weber R, Morrison W, Glisson B, Trotti A, Ridge JA, Chao C, Peters G, Lee DJ, Leaf A, Ensley J, Cooper J. Concurrent chemotherapy and radiotherapy for organ preservation in advanced laryngeal cancer. N. Engl. J. Med. 2003;349(22):2091-2098. https://doi.org/10.1056/NEJMoa031317

Forastiere AA, Zhang Q, Weber RS, Maor MH, Goepfert H, Pajak TF, Morrison W, Glisson B, Trotti A, Ridge JA, Thorstad W, Wagner H, Ensley JF, Cooper JS. Long-term results of RTOG 91-11: A comparison of three nonsurgical treatment strategies to preserve the larynx in patients with locally advanced larynx cancer. J. Clin. Oncol. 2013;31(7):845-852. https://doi.org/10.1200/JCO.2012.43.6097

Pignon JP, Bourhis J, Domenge C, Designe L. Chemotherapy added to locoregional treatment for head and neck squamous-cell carcinoma: three meta-analyses of updated individual data. MACH-NC Collaborative Group. Meta-Analysis of Chemotherapy on Head and Neck Cancer. Lancet. 2000;355(9208):949-955. https://doi.org/10.1016/S0140-6736(00)90011-4

Pignon JP, Maitre A, Maillard E, Bourhis J. Meta-Analysis of Chemotherapy in Head and Neck Cancer (MACHNC): An Update on 93 Randomised Trials and 17,346 Patients. Radiother. Oncol. 2009;92(1):4-14. https://doi.org/10.1016/j.radonc.2009.04.014

Lorch JH, Goloubeva O, Haddad RI, Cullen K, Sarlis N, Tishler R, Tan M, Fasciano J, Sammartino DE, Posner MR. Induction chemotherapy with cisplatin and fluorouracil alone or in combination with docetaxel in locally advanced squamous-cell cancer of the head and neck: long-term results of the TAX 324 randomised phase 3 trial. Lancet Oncol.2011;12(2):153-159. https://doi.org/10.1016/S1470-2045(10)70279-5

Vermorken JB, Remenar E, van Herpen C, Gorlia T, Mesia R, Degardin M, Stewart JS, Jelic S, Betka J, Preiss JH, van den Weyngaert D, Awada A, Cupissol D, Kienzer HR, Rey A, Desaunois I, Bernier J, Lefebvre JL. Cisplatin, fluorourcil, and docetaxel in unresectable head and neck cancer. N. Engl. I. J. Med. 2007;357(17):1695-1704. https://doi.org/10.1056/NEJMoa071028

Bonner JA, Harari PM, J. Giralt J, Azarnia N, Shin DM, Cohen RB, Jones CU, Sur R, Raben D, Jassem J, Ove R, Kies MS, Baselga J, Youssoufian H, Amellal N, Rowinsky EK, Ang KK. Radiotherapy plus cetuximab for squamous-cell carcinoma of the head and neck. N. Engl. J. Med. 2006;354(6):567-578. https://doi.org/10.1056/NEJMoa05342

Bourhis J, Sire C, Graff P, Gregoire V, Maingon P, Calais G, Gery B, Martin L, Alfonsi M, Desprez P, Pignon T, Bardet E, Rives M, Geoffrois L, Daly-Schveitzer N, Sen S, Tuchais C, Dupuis O, Guerif S, Lapeyre M, Favrel V, Hamoir M, Lusinchi A, Temam S, Pinna A, et al. Concomitant chemoradiotherapy versus acceleration of radiotherapy with or without concomitant chemotherapy in locally advanced head and neck carcinoma (GORTEC 99-02): An open-label phase 3 randomised trial. Lancet Oncol. 2012;13(2):145-153. https://doi.org/10.1016/S1470-2045(11)70346-1

Bonner JA, Harari PM, Giralt J, Cohen RB, Jones CU, Sur RK, Raben D, Baselga J, Spencer SA, Zhu J, Youssoufian H, Rowinsky EK, Ang KK. Radiotherapy plus cetuximab for locoregionally advanced head and neck cancer: 5-year survival data from a phase 3 randomised trial, and relation between cetuximab-induced rash and survival. Lancet Oncol. 2010;11(1):21-28. https://doi.org/10.1016/S1470-2045(09)70311-0

Bonner J. A. Cetuximab or cisplatin as a radiosensitizer in locoregionally advanced head and neck cancer: recent results / Transl. Cancer Res. 2016;5(3):234-237. https://doi.org/10.21037/tcr.2016.06.22

Bonner J, Giralt J, Harari P, Spencer S, Schulten J, Hossain A, Chang SC, Chin S, Baselga J. Cetuximab and radiotherapy in laryngeal preservation for cancers of the larynx and hypopharynx: a secondary analysis of a randomized clinical trial. JAMA Otolaryngol. Head Neck Surg. 2016;142(9):842-849. https://doi.org/10.1001/jamaoto.2016.1228

Haigentz M, Vermorken JB, Forastiere AA, Corry J, Beitler JJ, Strojan P, Hartl DM, Rodrigo JP, Bradford CR, Rinaldo A, Takes RP, Mendenhall WM, Shaha AR, Wolf GT, Ferlito A. When is chemotherapy in head and neck squamous cell carcinoma not indicated? Eur. Arch. Otorhinolaryngol. 2015;272(4):781-787. https://doi.org/10.1007/s00405-014-2894-9

Magrini SM, Buglione M, Corvo R, Pirtoli L, Paiar F, Ponticelli P, Petrucci A, Bacigalupo A, Crociani M, Lastrucci L, Vecchio S, Bonomo P, Pasinetti N, Triggiani L, Cavagnini R, Costa L, Tonoli S, Maddalo M, Grisanti S. Cetuximab and radiotherapy versus cisplatin and radiotherapy for locally advanced head and neck cancer: a randomized phase II trial. J. Clin. Oncol. 2016;34(5):427-435. https://doi.org/10.1200/JCO.2015.63.1671

Ang KK, Zhang Q, Rosenthal D, Nguyen-Tan PF, Sherman EJ, Weber RS, Galvin JM, Bonner JA, Harris J, El-Naggar AK, Gillison ML, Jordan RC, Konski AA, Thorstad WL, Trotti A, Beitler JJ, Garden AS, Spanos WJ, Yom SS, Axelrod RS. Randomized phase III trial of concurrent accelerated radiation plus cisplatin with or without cetuximab for stage III to IV head and neck carcinoma: RTOG 0522. J. Clin. Oncol. 2014;32(27):2940-2950. https://doi.org/10.1200/JCO.2013.53.5633

Tarnawski R, Fowler J, Skladowski K, Swierniak A, Suwiński R, Maciejewski B, Wygoda A. How fast is repopulation of tumor cells during the treatment gap? Int. J. Radiat. Oncol. Biol. Phys. 2002;54(1):229-236. https://doi.org/10.1016/S0360-3016(02)02936-X

Peters LJ, Withers HR. Applying radiobiological principles to combined modality treatment of head and neck cancer: the time factor. Int. J. Radiat. Oncol. Biol. Phys. 1997;39(4):831-836. https://doi.org/10.1016/S0360-3016(97)00466-5

Chapman JD. Can the two mechanisms of tumor cell killing by radiation be exploited for therapeutic gain? J. Radiat. Res. 2014;55(1):2-9. https://doi.org/10.1093/jrr/rrt111

Withers TR, Taylor JM, Maciejtwski B. The hazard of accelerated tumor clonogen repopulation during radiotherapy. Acta Oncol. 1988;27(2):131-146. https://doi.org/10.3109/02841868809090333

Dische S, Saunders M, Barrett A, Harvey A, Gibson D, Parmar M. A randomized multicentre trial of CHART versus conventional radiotherapy in head and neck cancer. Radiother. Oncol. 1997;44(2):123-136. https://doi.org/10.1016/S0167-8140(97)00094-7

Overgaard J, Hansen HS, Specht L, Overgaard M, Grau C, Andersen E, Bentzen J, Bastholt L, Hansen O, Johansen J, Andersen L, Evensen JF. Five compared with six fractions per week of conventional radiotherapy of squamous-cell carcinoma of head and neck: DAHANCA 6 and 7 randomised controlled trial. Lancet. 2003;362(9388):933-940. https://doi.org/10.1016/S0140-6736(03)14361-9

Harrington K, Jankowsa P, Hingorani M. Molecular biology for the radiation oncologist: the 5 Rs of radiobiology meet the hallmarks of cancer. Clin. Oncol. 2007;19:561-571. https://doi.org/10.1016/j.clon.2007.04.009

O'Sullivan B, Huang SH, Siu LL, Waldron J, Zhao H, Perez-Ordonez B, Weinreb I, Kim J, Ringash J, Bayley A, Dawson LA, Hope A, Cho J, Irish J, Gilbert R, Gullane P, Hui A, Liu FF, Chen E, Xu W. Deintensification candidate subgroups in human papillomavirus-related oropharyngeal cancer according to minimal risk of distant metastasis. J. Clin. Oncol. 2013;31(5):543-550. https://doi.org/10.1200/JCO.2012.44.0164

Marur S, Li S, Cmelak AJ, Zhao WJ, Ferris RL, Westra WH, Gilbert J, Bauman JE, Wagner LI, Trevarthen DR, Balkrishna J, Murphy BA, Agrawal N, Colevas AD, Chung CH, Burtness B. E1308: phase II trial of induction chemotherapy followed by reduced-dose radiation and weekly cetuximab in patients with HPV-associated resectable squamous cell carcinoma of the oropharynx - ECOG-ACRIN Cancer Research Group. J. Cljn. Oncol. 2017;35(5):490-497. https://doi.org/10.1200/JCO.2016.68.3300

Chen AM, Felix C, Wang PC, Hsu S, Basehart V, Garst J, Beron P, Wong D, Rosove MH, Rao S, Melanson H, Kim E, Palmer D, Qi L, Kelly K, Steinberg ML, Kupelian PA, Daly ME. Reduced-dose radiotherapy for human papillomavirus-associated squamous-cell carcinoma of the oropharynx: a single-arm, phase 2 study. Lancet Oncol. 2017;18(6):803-811. https://doi.org/10.1016/S1470-2045(17)30246-2

Hegde JV, Shaverdian N, Daly ME, Felix C,Wong DL, Rosove MH, Garst JH, Wang P‐C, Veruttipong D, Rao S, Fragoso RC, Riess JW, Steinberg ML, Chen AM. Patient-reported quality-of-life outcomes after de-escalated chemoradiation for human papillomavirus-positive oropharyngeal carcinoma: Findings from a phase 2 trial. Cancer. 2018;124(3):521-529. https://doi.org/10.1002/cncr.30954

Lydiatt WM, Patel SG, O'Sullivan B, Brandwein MS, Ridge JA, Migliacci JC, Loomis AM, Shah JP. Head and Neck cancers-major changes in the American Joint Committee on cancer eighth edition cancer staging manual. CA Cancer J. Clin. 2017;67(2):122-137. https://doi.org/10.3322/caac.21389

Brierley JD, Gospodarowicz MK, Wittekind C, editors. TNM Classification of Malignant Tumours. 8th ed. Chichester: Wiley-Blackwell; 2017. 272 р. https://doi.org/10.1002/9780471420194.tnmc26.pub3

Fu KK, Pajak TF, Trotti A, Jones CU, Spencer SA, Phillips TL, Garden AS, Ridge JA, Cooper JS, Ang KK. A Radiation Therapy Oncology Group (RTOG) phase III randomized study to compare hyperfractionation and two variants of accelerated fractionation to standard fractionation radiotherapy for head and neck squamous cell carcinomas: first report of RTOG 9003. Int. J. Radiat. Oncol. Biol. Phys. 2000;48(1):7-16. https://doi.org/10.1016/S0360-3016(99)90019-6

Beitler JJ, Zhang Q, Fu KK, Trotti A, Spencer SA, Jones CU, Garden AS, Shenouda G, Harris J, Ang KK. Final results of local-regional control and late toxicity of RTOG 9003: a randomized trial of altered fractionation radiation for locally advanced head and neck cancer. Int. J. Radiat. Oncol. Biol. Phys. 2014;89(1):13-20. https://doi.org/10.1016/j.ijrobp.2013.12.027

Landberg T, Chavaudra J, Dobbs J, Gerard JP, Hanks G, Horiot JC, Johansson KA, Moller T, Purdy J, Suntharalingam N, Svensson H. ICRU Report 62: prescribing, recording, and reporting photon-beam therapy (supplement to ICRU Report 50). J. ICRU. 1999;32(1). https://doi.org/10.1093/jicru/os32.1.Report62

International Commission on Radiation Units and Measurements. ICRU Report 83: prescribing, recording, and reporting photon-beam intensity-modulated radiation therapy (IMRT). J. ICRU. 2010;10(1). https://doi.org/10.1093/jicru/10.1.Report83

Garden AS, Dong L, Morrison WH, Stugis EM, Glisson BS, Frank SJ, Beadle BM, Gunn GB, Schwartz DL, Kies MS, Weber RS, Ang KK, Rosenthal DI. Patterns of disease recurrence following treatment of oropharyngeal cancer with intensity modulated radiation therapy. Int. J. Radiat. Oncol. Biol. Phys. 2013;85(4):941-947. https://doi.org/10.1016/j.ijrobp.2012.08.004

Bernier J, Cooper JS, Pajak TF, van Glabbeke M, Bourhis J, Forastiere A, Ozsahin EM, Jacobs JR, Jassem J, Ang KK, Lefebvre JL. Defining risk levels in locally advanced head and neck cancers: a comparative analysis of concurrent postoperative radiation plus chemotherapy trials of the EORTC (#22931) and RTOG (# 9501). Head Neck. 2005;27(10):843-850. https://doi.org/10.1002/hed.20279

Cooper JS, Zhang Q, Pajak TF, Forastiere АА, Jacobs J, Saxman SB, Kish JA, Kim HE, Cmelak AJ, Rotman М, Lustig R, Ensley JF, Thorstad W, Schultz CJ, Yom SS, Ang КК. Long-term follow-up of the RTOG 9501/intergroup phase III trial: postoperative concurrent radiation therapy and chemotherapy in high-risk squamous cell carcinoma of the head and neck. Int. J. Radiat. Oncol. Biol. Phys. 2012;30;84(5):1198-1205. https://doi.org/10.1016/j.ijrobp.2012.05.008

Pignon JP, Bourhis J, Domenge C, Designe L. Chemotherapy added to locoregional treatment for head and neck squamous-cell carcinoma: three meta-analyses of updated individual data. Lancet. 2000;355(9208):949-955. https://doi.org/10.1016/S0140-6736(00)90011-4

Horiot JC, Le Fur R, N'Guven T, Chenal C, Schraub S, Alfonsi S, Gardani G, van den Bogaert W, Danczak S, Bolla M. Hyperfractionation versus conventional fractionation in oropharyngeal carcinoma: final analysis of a randomized trial of the EORTC cooperative group of radiotherapy. Radiother. Oncol. 1992;25(4):231-241. https://doi.org/10.1016/0167-8140(92)90242-M

Fu KK, Clery M, Ang KK, Byhardt RW, Maor MH, Beitler JJ. Randomized Phase I/II trial of two variants of accelerated fractionation radiotherapy regimens for advanced head and neck cancer: Results of RTOG 88-09. Int. J. Radiat. Oncol. Biol. Phys. 1995;32(3):589-597. https://doi.org/10.1016/0360-3016(95)00078-D

Overgaard J, Mohanti BK, Begum N, Ali R, Agarwal JP, Kuddu M, Bhasker S, Tatsuzaki H, Grau C. Five versus six fractions of radiotherapy per week for squamous-cell carcinoma of the head and neck (IAEA-ACC study): a randomised, multicentre trial. Lancet Oncol. 2010;11(6):553-560. https://doi.org/10.1016/S1470-2045(10)70072-3

Lyhne NM, Primdahl H, Kristensen CA, Andersen E, Johansen J, Andersen LJ, Evensen J, Mortensen HR, Overgaard J. The DAHANCA 6 randomized trial: Effect of 6 vs 5 weekly fractions of radiotherapy in patients with glottic squamous cell carcinoma. Radiother. Oncol. 2015;117(1):91-98. https://doi.org/10.1016/j.radonc.2015.07.004

Bourhis J, Overgaard J, Audry H, Ang KK, Saunders M, Bernier J, Horiot JC, Le Maitre A, Pajak TF, Poulsen MG, O'Sullivan B, Dobrowsky W, Hliniak A, Skladowski K, Hay JH, Pinto LH, Fallai C, Fu KK, Sylvester R, Pignon JP. Hyperfractionated or accelerated radiotherapy in head and neck cancer: a meta-analysis. Lancet. 2006;368(9538):843-854. https://doi.org/10.1016/S0140-6736(06)69121-6

Budach W, Hehr T, Budach V, Belka C, Dietz K. A metaanalysis of hyperfractionated and accelerated radiotherapy and combined chemotherapy and radiotherapy regimens in unresected locally advanced squamous cell carcinoma of the head and neck. BMC Cancer. 2006;6:28-33. https://doi.org/10.1186/1471-2407-6-28

Bourhis J, Sire C, Graff P, Gregoire V, Maingon P, Calais G, Gery B, Martin L, Alfonsi M, Desprez P, Pignon T, Bardet E, Rives M, Geoffrois L, Daly-Schveitzer N, Sen S, Tuchais C, Dupuis O, Guerif S, Lapeyre M, Favrel V, Hamoir M, Lusinchi A, Temam S, Pinna A, Tao YG, Blanchard P, Auperin A. Concomitant chemoradiotherapy versus acceleration of radiotherapy with or without concomitant chemotherapy in locally advanced head and neck carcinoma (GORTEC 99-02): An open-label phase 3 randomised trial. Lancet Oncol. 2012;13(2):145-153. https://doi.org/10.1016/S1470-2045(11)70346-1

Lacas B, Bourhis J, Overgaard J, Zhang Q, Gregoire V, Nankivell M, Zackrisson B, Szutkowski Z, Suwinski R, Poulsen M, O'Sullivan B, Corvo R, Laskar SG, Fallai C, Yamazaki H, Dobrowsky W, Cho KH, Beadle B, Langendijk JA, Viegas CMP, Hay J, Lotayef M, Parmar MK, Auperin A, van Herpen C. Role of radiotherapy fractionation in head and neck cancers (MARCH): an updated meta-analysis. Lancet Oncol. 2017;18(9):1221-1237. https://doi.org/10.1016/S1470-2045(17)30458-8

NCCN Guidelines: Head and Neck Cancers. Version 1. 2019 [Internet]. Available from: https://www.nccn.org/professionals/physician_gls/default.aspx.




Загрузок PDF: 180
Опубликован
2021-05-13
Как цитировать
1.
Пархоменко ЛБ. РЕЖИМЫ НЕТРАДИЦИОННОГО ФРАКЦИОНИРОВАНИЯ В ЛУЧЕВОЙ ТЕРАПИИ РАКА ГОЛОВЫ И ШЕИ. Журнал ГрГМУ (Journal GrSMU) [Интернет]. 13 май 2021 г. [цитируется по 4 декабрь 2024 г.];17(4):368-76. доступно на: http://journal-grsmu.by/index.php/ojs/article/view/2576