ПЕРСПЕКТИВЫ ПРИМЕНЕНИЯ КЛЕТОЧНОЙ ТЕРАПИИ У НЕДОНОШЕННЫХ ДЕТЕЙ
Аннотация
Статья посвящена перспективам применения клеточной терапии у недоношенных детей. Аутологичные мезенхимальные стромальные стволовые клетки пуповинно-плацентарного происхождения и клетки пуповинной крови являются мультипотентными стволовыми клетками, способными к дифференцировке в разных направлениях и широко используются для разработки новых клеточных биомедицинских технологий. Авторы представляют обзор применения аутологичных мезенхимальных стромальных стволовых клеток и клеток пуповинной крови у новорожденных детей, перспективы их использования у недоношенных младенцев с бронхолегочной дисплазией, гипоксически-ишемическим повреждением центральной нервной системы.
Литература
D’Angio CT, Ambalavanan N, Carlo WA, McDonald SA, Skogstrand K, Hougaard DM, Shankaran S, Goldberg RN, Ehrenkranz RA, Tyson JE, Stoll BJ, Das A, Higgins RD. Blood cytokine profiles associated with distinct patterns of bronchopulmonary dysplasia among extremely low birth weight infants. J. Pediatr. 2016;174:45-51. http://doi.org/10.1016/j.jpeds.2016.03.058.
Ahn SY, Chang YS, Sung DK, Sung SI, Yoo HS, Im GH. Choi SJ, Park WS. Optimal route for mesenchymal stem cells transplantation after severe intraventricular hemorrhage in newborn rats. PLoS One. 2015;10(7):e0132919. http://doi.org/10.1371/journal.pone.0132919.
Parad RB, Davis JM, Lo J, Thomas M, Marlow N, Calvert S, Peacock JL, Greenough A. Prediction of respiratory outcome in extremely low gestational age infants.Neonatology. 2015;107(4):241-248. http://doi.org/10.1159/000369878.
Cotten CM, Murtha AP, Goldberg RN, Grotegut CA, Smith PB, Goldstein RF, Fisher KA, Gustafson KE, Waters-Pick B, Swamy GK, Rattray B, Tan S, Kurtzberg J. Feasibility of autologous cord blood cells for infants with hypoxic-ischemic encephalopathy. J. Pediatr. 2014;164(5):973-979. http://doi.org/10.1016/j.jpeds.2013.11.036.
Ahn SY, Chang YS, Sung DK, Sung SI, Ahn JY, Park WS. Pivotal role of brain derived neurotrophic factor secreted by mesenchymal stem cells in severe intraventricular hemorrhage in the newborn rats. Cell Transplant. 2017;26(1):145-156. http://doi.org/10.3727/096368916X692861.
Parad RB, Davis JM, Lo J, Thomas M, Marlow N, Calvert S, Peacock JL, Greenough A. Prediction of respiratory outcome in extremely low gestational age infants.Neonatology. 2015;107(4):241-248. http://doi.org/10.1159/000369878.
Sung DK, Chang YS, Ahn SY, Sung SI, Yoo HS, Choi SJ, Kim SY, Park WS. Optimal route for human umbilical cord blood-derived mesenchymal stem cell transplantation to protect against neonatal hyperoxic lung injury: gene expression profiles and histopathology. PLoS One. 2015;10(8):e0135574.http://doi.org/10.1371/journal.pone.0135574.
Ahn SY, Chang YS, Park WS. Stem cell for neonatal brain disorders. Neonatology. 2016;109(4):377-383. http://doi.org/10.1159/000444905.
Wang TN, Tio M, Lee W, Beerheide W, Udolph G. Neural differentiation of mesenchymal-like stem cells from cord blood. Biochem. Biophys. Res. Commun. 2007;357(4):1021-1027.
Nishiyama N, Mioshi S, Hida N, Uyama T, Okamoto K, Ikegami Y, Miyado K, Segawa K, Terai M, Sakamoto M, Ogawa S, Umezawa A. The significant cardiomyogenic potential of human umbilical cord blood-derived mesenchymal stem cells. Stem cells. 2007;25(8):2017-2024.
Sarugaser R, Lickorish D, Baksh D, Hosseini MM, Davies JE. Human umbilical cord perivascular (HUCPV) cells: a source of mesenchymal progenitors. Stem cells. 2005;23(2):220-229.
Kurtzberg J. Umbilical Cord Blood Banking and Transplation. In: Hillyer CD, Silberstein LE, Ness MP, Kenneth C, editors. Blood banking and transfusion medicine. Philadelphia: Churchill Livingstone; 2003. p. 593-598.
Chang YS, Ahn SY, Yoo HS, Sung SI, Choi SJ, Oh WI, Park WS. Mesenchymal stem cells for bronchopulmonary dysplasia: phase 1 dose-escalation clinical trial. J. Pediatr. 2014;164(5):966-972. http://doi.org/10.1016/j.jpeds.2013.12.011.
Ahn SY, Chang YS, Sung DK, Yoo HS, Sung SI, Choi SJ, Park WS. Cell type-dependent variation in paracrine potency determines therapeutic efficacy against neonatal hyperoxic lung injury. Cytotherapy. 2015;17(8):1025-1035. http://doi.org/10.1016/j.jcyt.2015.03.008.
Carroll J, Borlongan C. Adult Stem Cell Therapy for Acute Brain Injury in Children. CNS Neurol. Disord. Drug Targets. 2008;7(4):361-369.
Lee I, Jung K, Kim M, Park KI. Neural stem cells: properties and therapeutic potentials for hypoxic-ischemic brain injury in newborn infants. Pediatr. Int. 2010;52(6):855-865. http://doi.org/10.1111/j.1442-200X.2010.03266.x.
Takahashi K, Yamanaka S. Induced pluripotent stem cells in medicine and biology. Development. 2013;140(12):2257-2267. http://doi.org/10.1242/dev.092551.
Park WS, Sung SI, Ahn SY, Sung DK, Im GH, Yoo HS, Choi SJ, Chang YS. Optimal timing of mesenchymal stem cell therapy for neonatal intraventricular hemorrhage. Cell. Transplant. 2016;25(6):1131-1144. http://doi.org/10.3727/096368915X689640.
Nizjaeva NV, Nagovicyna MN, Kulikova GV, Tumanova UN, Poltavceva RA, Fedorova IA, Jushina MN, Pavlovich SV, Shhegolev AI. Uslovija poluchenija obrazcov tkani placenty dlja kultivirovanija multipotentnyh mezenhimnyh stromalnyh kletok [The conditions taking samples from placenta tissue for following cultivation of multipotent mesenchimal stromal cells]. Byulleten eksperimentalnoy biologii i meditsiny [Bulletin of Experimental Biology and Medicine]. 2016;162(10):500-506. (Russian).
Mark A, DeWitt MA, Magis W, Bray NL, Wang T, Berman JR, Urbinati F, Heo SJ, Mitros T, Munoz DP, Boffelli D, Kohn DB, Walters MC, Carroll D, Martin DI, Corn JE. Selection-free genome editing of the sickle mutation in human adult hematopoetic stem/progenitor cells. Sci. Transl. Med. 2016;8(360):360-364. http://doi.org/10.1126/scitranslmed.aaf9336.
Napoli E, Lippert T, Borlongan CV. Stem Cell Therapy: Repurposing Cell-Based Regenerative Medicine Beyond Cell Replacement. In: Turksen K. editor. Cell Biology and Translational Medicine. Vol. 1. Cham: Springer; 2018. p. 87-91. http://doi.org/10.1007/5584_2018_174.
Donega V, van Velthoven CT, Nijboer CH, Kavelaars A, Heijnen CJ. The endogenous regenerative capacity of the damaged newborn brain: boosting neurogenesis with mesenchymal stem cell treatment. J. Cereb. Blood Flow Metab. 2013;33(5):625-634. http://doi.org/10.1038/jcbfm.2013.3.
Yasuhara T, Matsukawa N, Yu G, Xu L, Mays RW, Kovach J, Deans R, Hess DC, Carroll JE, Borlongan CV. Transplantation of cryopreserved human bone marrow-derived multipotent adult progenitor cells of neonatal hypoxic-ischemic injury: targeting the hippocampus. Rev. Neurosci. 2006;17(1-2):215-225.
van Velthoven CT, Kavelaars A, van Bel F, Heijnen CJ. Mesenchymal stem cell transplantation changes the gene expression of the neonatal ischemic brain. Brain Behav. Immun. 2011;25(7):1342-1348. http://doi.org/10.1016/j.bbi.2011.03.021.
Luan Z, Liu W, Qu So, Qu SQ, Hu XH, Wang ZY, He S, Liu CQ, Xiao M. Treatment of newborns with severe injured brain with transplantation of human neural precursor cells. Zhonghua Er Ke Za Zhi [Chinese journal of pediatrics]. 2011;49(6):445-449. (Chinese).
Luan Z, Yin G, Hu X, Qu SQ, Wu NH, Yan FQ, Qian YM, Jin HY, Gong XJ. Treatment of an infant with severe neonatal hypoxic-ischemic encephalopathy sequelae with transplantation of human neural stem cells into cerebral ventricle. Zhonghua Er Ke Za Zhi [Chinese journal of pediatrics]. 2005;43(8):580-583. (Chinese).
