ВРОЖДЕННЫЙ ТОКСОПЛАЗМОЗ. КЛИНИЧЕСКОЕ НАБЛЮДЕНИЕ
Аннотация
В статье представлены обзор литературы и клиническое наблюдение новорожденного с врожденным токсоплазмозом. Обсуждаются трудности диагностики бессимптомной формы врожденного токсоплазмоза в раннем неонатальном периоде у одного из двойни новорожденного. Авторы отмечают, что тщательный сбор антенатального анамнеза (культура питания, наличие контактов матери с представительством кошачьих) анализ физического развития пациента, корректная интерпретация клинической ситуации, данных лабораторных методов исследования и клиническая настороженность в отношении врожденной инфекции TORCH-комплекса будут способствовать ранней диагностике заболевания. Своевременная этиопатогенетическая терапия позволит провести эффективное лечение и раннюю профилактику инвалидизирующих осложнений у пациента.
Литература
Karpov IA, Danilov DE, Ivanova MA. Toksoplazmoz. Minsk: BGMU; 2007. 18 р. (Russiаn).
Barycheva LYu, Golubeva MV, Kabulova MA, Kostornaya IV. Clinical and morphological features of malformations in children with congenital cytomegalovirus and toxoplasma infections. Rossijskij vestnik perinatologii i pediatrii [Russian Bulletin of Perinatology and Pediatrics]. 2015;60(3):50-57. (Russiаn).
Tizard IR, Chauhan SS, Lai CH. The prevalence and epidemiology of toxoplasmosis in Ontario. J Hyg (Lond). 1977;78(2):275-282. https://doi.org/10.1017/S0022172400056163
Pereira LH, Staudt M, Tanner CE, Embil JA. Exposure to Toxoplasma gondii and cat ownership in Nova Scotia. Pediatrics. 1992;89(6):1169-1172.
Hansen AR, Eichenwald EC, Stark AR, Martin CR, еditors. Cloherty and Stark's Manual of Neonatal Care. 8th ed. London: Wolters Kluwer; 2016. 1124 p.
Edwards JF, Dubey LP. Toxoplasma gondii abortion storm in sheep on a Texas farm and isolation of mouse virulent atypical genotype T. gondii from an aborted lamb from a chronically infected ewe. Vet Parasitol. 2013;192(13):129-136. https://doi.org/10.1016/j.vetpar.2012.09.037
Dubey JP, Sundar N, Hill D, Velmurugan GV, Bandini LA, Kwok OC, Majumdar D, Su C. High prevalence and abundant atypical genotypes of Toxoplasma gondii isolated from lambs destined for human consumption in the USA. Int J Parasitol. 2008;38(8-9):999-1006. https://doi.org/10.1016/j.ijpara.2007.11.012
Hill DE, Dubey JP. Toxoplasma gondii prevalence in farm animals in the United States. Int J Parasitol. 2013;43(2):107-113. https://doi.org/10.1016/j.ijpara.2012.09.012
Dubey JP, Hill DE, Jones JL, Hightower AW, Kirkland E, Roberts JM, Marcet PL, Lehmann T, Vianna MC, Miska K, Sreekumar C, Kwok OC, Shen SK, Gamble HR. Prevalence of viable Toxoplasma gondii in beef, chicken, and pork from retail meat stores in the United States: risk assessment to consumers. J Parasitol. 2005;91(5):10821093. https://doi.org/10.1645/GE-683.1
Coster LO. Parasitic infections in solid organ transplant recipients. Infect Dis Clin North Am. 2013;27(2):395-427. https://doi.org/10.1016/j.idc.2013.02.008
Martina MN, Cervera C, Esforzado N, Linares L, Torregrosa V, Sanclemente G, Hoyo I, Cofan F, Oppenheimer F, Miro JM, Campistol JM, Moreno A. Toxoplasma gondii primary infection in renal transplant recipients: two case reports and literature review. Transpl Int. 2011;24(1):e6-e12.
https://doi.org/10.1111/j.1432-2277.2010.01173.x
Herwaldt BL. Laboratory-acquired parasitic infections from accidental exposures. Clin Microbiol Rev. 2001;14(4):659688. https://doi.org/10.1128/CMR.14.3.659-688.2001
Boyer K, Hill D, Mui E, Wroblewski K, Karrison T, Dubey JP, Sautter M, Noble AG, Withers S, Swisher C, Heydemann P, Hosten T, Babiarz J, Lee D, Meier P. Toxoplasmosis Study Group. Unrecognized ingestion of Toxoplasma gondii oocysts leads to congenital toxoplasmosis and causes epidemics in North America. Clin Infect Dis. 2011;53(11):1081-1089. https://doi.org/10.1093/cid/cir667
Boyer KM, Holfels E, Roizen N, Swisher C, Mack D, Remington J, Withers S, Meier P. Toxoplasmosis Study Group. Risk factors for Toxoplasma gondii infection in mothers of infants with congenital toxoplasmosis: implications for prenatal management and screening. Am J Obstet Gynecol. 2005;192(2):564-571. https://doi.org/10.1016/j.ajog.2004.07.031
Nikitina EV, Gomon ES, Gomon MA. Toksoplazmoz i beremennost [Тoxoplasmosis and pregnancy]. Ohrana materinstva i detstva. 2014;2(24):75-79. (Russiаn).
Ivanova MA, Karpov IA, Tihon AK. Serologicheskaja rasprostranennost inficirovanija T. gondii sredi beremennyh zhenshhin i prognozirovanie vrozhdennogo toksoplazmoza v Minske (Respublika Belarus). Reproduktivnoe zdorove. Vostochnaja Evropa [Reproductive health. Eastern Europe]. 2015;6(42):33-40. (Russiаn).
Vogel N, Kirisits M, Michael E, Bach Н, Hostetter М, Boyer К, Simpson R, Holfels Е, Hopkins J, Mack D, Mets МВ, Swisher CN, Patel D, Roizen N, Stein L, Stein M, Withers S, Mui E, Egwuagu C, Remington J. Congenital toxoplasmosis transmitted from an immunologically competent mother infected before conception. Clin Infect Dis. 1996;23(5):1055-1060. https://doi.org/10.1093/clinids/23.5.1055
Elbez-Rubinstein A, Ajzenberg D, Dardé ML, Cohen R, Dumètre A, Yera H, Gondon E, Janaud JC, Thulliez P. Congenital toxoplasmosis and reinfection during pregnancy: case report, strain characterization, experimental model of reinfection, and review. J Infect Dis. 2009;199(2):280285. https://doi.org/10.1086/595793
Khan A, Dubey JP, Su C, Ajioka JW, Rosenthal BM, Sibley LD. Genetic analyses of atypical Toxoplasma gondii strains reveal a fourth clonal lineage in North America. Int J Parasitol. 2011;41(6):645-655. https://doi.org/10.1016/j.ijpara.2011.01.005
Grigg ME, Ganatra J, Boothroyd JC, Margolis TP. Unusual abundance of atypical strains associated with human ocular toxoplasmosis. J Infect Dis. 2001;184(5):633-639. https://doi.org/10.1086/322800
Sibley LD, Boothroyd JC. Virulent strains of Toxoplasma gondii comprise a single clonal lineage. Nature. 1992;359(6390):82-85. https://doi.org/10.1038/359082a0
Howe DK, Sibley LD. Toxoplasma gondii comprises three clonal lineages: correlation of parasite genotype with human disease. J Infect Dis. 1995;172(6):1561-1566. https://doi.org/10.1093/infdis/172.6.1561
Orehov KV, Barycheva Ju. Osobennosti vrozhdennogo toksoplazmoza u detej pervogo goda zhizni [Features of congenital toxoplasmosis in children of the first year of life]. Sibirskij medicinskij zhurna [Siberian Medical Journal]. 2004;1:63-65. (Russiаn).
Rymarenko NV, Vjalceva JuV. Vrozhdennyj toksoplazmoz pri mnogoplodnoj beremennosti - faktory riska pri vertikalnoj transmiscii [Congenital toxoplasmosis in multiple pregnancies - risk factors for vertical transmission]. Voprosy prakticheskoj pediatrii [Practical Pediatrics]. 2019;1:51-56. https://doi.org/10.20953/1817-7646-2019-1-51-56 (Russiаn).
Crino JP. Ultrasound and fetal diagnosis of perinatal infection. Clin Obstet Gynecol. 1999;42(1):71-80. https://doi.org/10.1097/00003081-199903000-00013
