РОЛЬ ПАНКРЕАТИЧЕСКИХ ЗВЕЗДЧАТЫХ КЛЕТОК В ПРОГРЕССИРОВАНИИ РАКА ПОДЖЕЛУДОЧНОЙ ЖЕЛЕЗЫ

  • Л. А. Можейко УО «Гродненский государственный медицинский университет»
Ключевые слова: поджелудочная железа, звездчатые клетки, рак поджелудочной железы

Аннотация

В настоящем обзоре проанализированы литературные сведения о взаимоотношениях звездчатых и раковых клеток поджелудочной железы и их возможной роли в прогрессировании опухолевого процесса. В присутствии раковых клеток панкреатические звездчатые клетки активируются, что выражается в усилении их пролиферации и миграции, стимуляции синтеза компонентов внеклеточного матрикса и формировании плотной фиброзной ткани вокруг опухоли. В свою очередь панкреатические звездчатые клетки способствуют росту опухоли, её химио- и радиорезистентности. Они индуцируют пролиферацию и распространение раковых клеток, образование отдаленных метастазов.

Литература

Watari N, Hotta Y, Mabuchi Y. Morphological studies on a vitamin A-storing cell and its complex with macrophage observed in mouse pancreatic tissues following excess vitamin A administration. Okajimas Folia Anat. Jpn. 1982;58(4-6):837-858.

Erkan M, Adler G, Apte MV, Bachem MG, Buchholz M, Detlefsen S, Esposito I, Friess H, Gress TM, Habisch HJ, Hwang RF, Jaster R, Kleeff J, Kloppel G, Kordes C, Logsdon CD, Masamune A, Michalski CW, Oh J, Phillips PA, Pinzani M, Reiser-Erkan C, Tsukamoto H, Wilson J. Stellatum: current consensus and discussion on pancreatic stellate cell research. Gut. 2012;61(2):172-178. doi: 10.1136/gutjnl-2011-301220.

Ferdek PE, Jakubowska MA. Biology of pancreatic stellate cells - more than just pancreatic cancer. Pflugers Arch. 2017;469(9):1039-1050. doi: 10.1007/s00424-017-1968-0.

Sirenko O.Yu. Pankreatichni zirchasti klitini yak morfologichna osnova rozvitku fibrozu pidshlunkovoi zalozi [Pancreatic stellate cells as a morphological basis for the development of pancreatic fibrosis]. Morfologiya. 2010;IV(1):5-12. (Ukrainian).

Bynigeri RR, Jakkampudi A, Jangala R, Subramanyam C, Sasikala M, Rao GV, Reddy D.N, Talukdar R. Pancreatic stellate cell: Pandora’s box for pancreatic disease biology. World J. Gastroenterol. 2017;23(3):382-405.

Warshaw AL, Fernandez-del Castillo C. Pancreatic carcinoma. N. Engl. J. Med. 1992;326(7):455-465. doi: 10.1056/NEJM199202133260706.

Cohen R, Neuzillet C, Tijeras-Raballand A, Faivre S, de Gramont A, Raymond E. Targeting cancer cell metabolism in pancreatic adenocarcinoma. Oncotarget. 2015;6 (19):16832-16847. doi: 10.18632/oncotarget.4160.

Apte MV, Xu Z, Pothula S, Goldstein D, Pirola RC, Wilson JS. Pancreatic cancer: The microenvironment needs attention too! Pancreatology. 2015;15(l):32-38. doi: 10.1016/j.pan.2015.02.013.

Bachem MG, Schneider E, Gross H, Weidenbach H, Schmid RM, Menke A, Siech M, Beger H, Grünert A, Adler G. Identification, culture, and characterization of pancreatic stellate cells in rats and humans. Gastroenterology. 1998;115:421-432.

Apte MV, Wilson JS. Dangerous liaisons: pancreatic stellate cells and pancreatic cancer cells. J. Gastroenterol. Hepatol. 2012;27(2):69-74. doi: 10.1111/j.1440-1746.2011.07000.x.

Phillips PA, McCarroll JA, Park S, Wu MJ, Pirola R, Korsten M, Wilson JS, Apte MV. Rat pancreatic stellate cells secrete matrix metalloproteinases: implications for extracellular matrix turnover. Gut. 2003;52(2):275-282.

Xu Z, Pothula SP, Wilson JS, Apte MV. Pancreatic cancer and its stroma: A conspiracy theory. World J.Gastroenterol. 2014;20(32):11216-11229. doi: 10.3748/ wjg.v20.i32.11216.

Buscail L, Bournet B, Dufresne M, Torrisani J, Cordelier P. [Advance in the biology of pancreatic of cancer]. Bull. Cancer. 2015;102(6 Suppl. 1):53-61. doi: 10.1016/S0007-4551(15)31218-2. (French).

Hwang RF, Hwang RF, Moore T, Arumugam T, Ramachandran V, Amos KD, Rivera A, Ji B, Evans DB, Logsdon CD. Cancer-associated stromal fibroblasts promote pancreatic tumor progression. Cancer Res.2008;68:918-926. doi: 10.1158/0008-5472.CAN-07- 5714.

Sousa CM, Biancur DE, Wang X, Halbrook CJ, Sherman MH, Zhang L, Kremer D, Hwang RF, Witkiewicz AK, Ying H, Asara JM, Evans RM, Cantley LC, Lyssiotis CA, Kimmelman AC. Pancreatic stellate cells support tumour metabolism through autophagic alanine secretion. Nature. 2016;536:479-483. doi: 10.1038/nature19084.

Han S, Delitto D, Zhang D, Sorenson HL, Sarosi GA, Thomas RM, Behrns KE, Wallet SM, Trevino JG, Hughes SJ. Primary outgrowth cultures are a reliable source of human pancreatic stellate cells. Lab. Investig. 2015;95(11):1331-1340. doi: 10.1038/labinvest.2015.117.

Han L, Ma J, Duan W, Zhang L, Yu S, Xu Q, Lei J, Li X, Wang Z, Wu Z, Huang JH, Wu E, Ma Q, Ma Z. Pancreatic stellate cells contribute pancreatic cancer pain via activation of sHH signaling pathway. Oncotarget. 2016;7(14):18146-18158. doi: 10.18632/oncotarget.7776.

Braganza JM, Lee SH, McCloy RF, McMahon MJ. Chronic pancreatitis. Lancet. 2011;377:1184-1197.

Xu Z, Vonlaufen A, Phillips P A, Fiala-Beer E, Zhang X, Yang L, Biankin AV, Goldstein D, Pirola RC, Wilson JS, Apte MV. Role of pancreatic stellate cells in pancreatic cancer metastasis. Am. J. Pathol. 2010;177(5):2585-2596. doi: 10.2353/ajpath.2010.090899.

Kikuta K, Masamune A, Watanabe T, Ariga H, Itoh H, Hamada S, Satoh K, Egawa S, Unno M, Shimosegawa T. Pancreatic stellate cells promote epithelial-mesenchymal transition in pancreatic cancer cells. Biochem. Biophys. Res. Commun. 2010;403(3-4):380-384.

Ikenaga N, Ohuchida K, Mizumoto K, Cui L, Kayashima T, Morimatsu K, Moriyama T, Nakata K, Fujita H, Tanaka M. CD10+ pancreatic stellate cells enhance the progression of pancreatic cancer. Gastroenterology. 2010;139(3):1041-1051.

Bachem MG, Schunemann M, Ramadani M, Siech M, Beger H, Buck A, Zhou S, SchmidKotsas A, Adler G. Pancreatic carcinoma cells induce fibrosis by stimulating proliferation and matrix synthesis of stellate cells. Gastroenterology. 2005;128(4):907-921.

Vonlaufen A, Joshi S, Qu C, Phillips PA, Xu Z, Parker NR, Toi CS, Pirola RC, Wilson JS, Goldstein D, Apte MV. Pancreatic stellate cells: partners in crime with pancreatic cancer cells. Cancer Res. 2008;68(7):2085-2093. doi: 10.1158/0008-5472.CAN-07-2477.

Erkan M, Hausmann S, Michalski CW, Fingerle AA, Dobritz M, Kleeff J, Friess H. The role of stroma in pancreatic cancer: diagnostic and therapeutic implications. Nat. Rev. Gastroenterol. Hepatol. 2012;9(8):454-467. doi: 10.1038/nrgastro.2012.115.

Apte MV. Desmoplastic reaction in pancreatic cancer: role of pancreatic stellate cells. Pancreas. 2004;29(3):179-187.

Schneiderhan W, Diaz F, Fundel M, Zhou S, Siech M, Hasel C, Moller P, Gschwend JE, Seufferlein T, Gress T, Adler G, Bachem MG. Pancreatic stellate cells are an important source ofMMP-2 in human pancreatic cancer and accelerate tumor progression in a murine xenograft model and CAM assay. J Cell Sci. 2007;120(3):512-519. doi: 10.1242/jcs.03347.

Berchtold S, Grünwald B, Krüger A, Reithmeier A, Hähl T, Cheng T, Feuchtinger A, Born D, Erkan M, Kleeff J, Esposito I. Collagen type V promotes the malignant phenotype of pancreatic ductal adenocarcinoma. Cancer Lett. 2015;356(2 Pt.):721-732. doi: 10.1016/j. canlet.2014.10.020.

Rizwani W, Allen AE, Trevino JG. Hepatocyte growth factor from a clinical perspective: a pancreatic cancer challenge. Cancers (Basel). 2015;7(3):1785-1805. doi: 10.3390/cancers7030861.

Luttenberger T, Schmid-Kotsas A, Menke A, Siech M, Beger H, Adler G, Grunert A, Bachem MG. Plateletderived growth factors stimulate proliferation and extracellular matrix synthesis of pancreatic stellate cells: implications in pathogenesis of pancreas fibrosis. Lab. Invest. 2000;80(1):47-55.

Schneider E, Schmid-Kotsas A, Zhao J, Weidenbach H, Schmid R.M, Menke A, Adler G, Waltenberger J, Grunert A, Bachem MG. Identification of mediators stimulating proliferation and matrix synthesis of rat pancreatic stellate cells. Am. J. Physiol., Cell Physiol. 2001;281(2):532-543. doi: 10.1152/ajpcell.2001.281.2.C532.

Wilson JS, Pirola RC, Apte MV. Stars and stripes in pancreatic cancer: role of stellate cells and stroma in cancer progression. Front. Physiol. 2014;5:52. doi: 10.3389/fphys.2014.00052.

Neesse A, Krug S, Gress TM, Tuveson DA, Michl P. Emerging concepts in pancreatic cancer medicine: targeting the tumor stroma. Onco Targets Ther. 2013;7:33-43. doi: 10.2147/OTT.S38111.

Rhim AD, Oberstein PE, Thomas DH, Mirek ET, Palermo CF, Sastra SA, Decleva EN, Saunders T, Becerra CP, Tattersall IW, Westphalen CB, Kitajewski J, Fernandez-Barrena MG, Fernandez-Zapico ME, Lacobuzio-Donahue C, Olive KP, Stanger BS. Stromal elements act to restrain, rather than support, pancreatic ductal adenocarcinoma. Cancer Cell. 2014;25:735-747. doi: 10.1016/j.ccr.2014.04.021.

Laklai H, Miroshnikova YA, Pickup MW, Collisson EA, Kim GE, Barrett AS, Hill RC, Lakins JN, Schlaepfer DD, Mouw JK, LeBleu VS, Roy N, Novitskiy SV, Johansen JS, Poli V0, Kalluri R, Iacobuzio-Donahue CA, Wood LD, Hebrok M, Hansen K, Moses HL, Weaver VM. Genotype tunes pancreatic ductal adenocarcinoma tissue tension to induce matricellular fibrosis and tumor progression. Nat. Med. 2016;22(5):497-505. doi: 10.1038/nm.4082.

Olive KP, Jacobetz MA, Davidson CJ, Gopinathan A, McIntyre D, Honess D, Madhu B, Goldgraben MA, Caldwell ME, Allard D, Frese KK, Denicola G, Feig C, Combs C, Winter SP, Ireland Zecchini H, Reichelt S, Howat WJ, Chang A, Dhara M, Wang L, Ruckert F, Grutzmann R, Pilarsky C, Izeradjene K, Hingorani SR, Huang P, Davies S E, Plunkett W, Egorin M, Hruban RH, Whitebread N, McGovern K, Adams J, Iacobuzio-Donahue C, Griffiths J, Tuveson DA. Inhibition of Hedgehog signaling enhances delivery of chemotherapy in a mouse model of pancreatic cancer. Science. 2009;324(5933):1457-1461. doi: 10.1126/science.1171362.

Dangi-Garimella S, Sahai V, Ebine K, Kumar K, Munshi H.G. Three-dimensional collagen I promotes gemcitabine resistance in vitro in pancreatic cancer cells through HMGA2-dependent histone acetyltransferase expression. PLoS One. 2013;8(5):e64566. doi: 10.1371/ journal. pone.0064566.

Mantoni TS, Lunardi S, Al-Assar O, Masamune A, Brunner TB. Pancreatic stellate cells radioprotect pancreatic cancer cells through beta1-integrin signaling. Cancer Res. 2011;71(10):3453-3458. doi: 10.1158/0008-5472.CAN-10-1633.

Masamune A, Kikuta K, Watanabe T, Satoh K, Hirota M, Shimosegawa T. Hypoxia stimulates pancreatic stellate cells to induce fibrosis and angiogenesis in pancreatic cancer. Am. J. Physiol. Gastrointest Liver Physiol. 2008;295(4):709-717. doi: 10.1152/ajpgi.90356.2008.

Whatcott CJ, Diep CH, Jiang P, Watanabe A, LoBello J, Sima C, Hostetter G, Shepard HM, Von Hoff DD, Han H. Desmoplasia in primary tumors and metastatic lesions of pancreatic cancer. Clin. Cancer Res. 2015;21(15):3561- 3568. doi: 10.1158/1078-0432.CCR-14-1051.

Froeling FE, Feig C, Chelala C, Dobson R, Mein CE, Tuveson DA, Clevers H, Hart I R Kocher HM. Retinoic acid-induced pancreatic stellate cell quiescence reduces paracrine Wnt-beta-catenin signaling to slow tumor progression. Gastroenterology. 2011;141(4):1486-1497. doi: 10.1053/j.gastro.2011.06.047.

Chronopoulos A, Robinson B, Sarper M, Cortes E, Auernheimer V, Lachowski D, Attwood S, Garcia R, Ghassemi S, Fabry B, Del Rio HA. ATRA mechanically reprograms pancreatic stellate cells to suppress matrix remodelling and inhibit cancer cell invasion. Nat. Commun. 2016;7:12630. doi: 10.1038/ncomms12630.

Elnikova AA. Mikrookruzhenie opuholi – tyomnaya loshadka v protivoopuholevoy terapii [Tumor micro environment – a dark horse in anticancer chemotherapy]. Zdorove obrazovanie v XXI veke. 2015;17(1):84-86. (Russian).




Загрузок PDF: 263
Опубликован
2018-05-04
Как цитировать
1.
Можейко ЛА. РОЛЬ ПАНКРЕАТИЧЕСКИХ ЗВЕЗДЧАТЫХ КЛЕТОК В ПРОГРЕССИРОВАНИИ РАКА ПОДЖЕЛУДОЧНОЙ ЖЕЛЕЗЫ. Журнал ГрГМУ (Journal GrSMU) [Интернет]. 4 май 2018 г. [цитируется по 22 июнь 2024 г.];16(2):125-31. доступно на: http://journal-grsmu.by/index.php/ojs/article/view/2236

Наиболее читаемые статьи этого автора (авторов)

1 2 > >>