РОЛЬ МАГНИЯ В ПАТОГЕНЕЗЕ ДЕПРЕССИВНЫХ РАССТРОЙСТВ, НЕКОТОРЫХ КОМОРБИДНЫХ ЗАБОЛЕВАНИЙ И СПОСОБЫ ИХ КОРРЕКЦИИ




А. В. Гладкевич (Gladkevich A.V.), В. А. Снежицкий (Snezhitskiy V.A.), С. В. Тишковский (Тishkovskiy S.V.), В. Адомайтине (Adomaitiene V.), Д. Лескаускас (Leskauskas D.), И. В. Медведева (Medvedeva I.V.), С. Игумнов (Igumnov S.), Э. Арнолдуссен (Arnoldussen E.), Э. A. Гладкевич (Gladkevich E. A.), Ф. Боскер (Bosker F.J.), Т. В. Раева (Raeva T.V.), А. Г. Санников (Sannikov A.G.), Е. Ф. Дороднева (Dorodneva E.F.)

Аннотация


В обзоре представлены новейшие результаты мировых исследований, касающиеся физиологии магния в организ­ме человека, а также значения магния в патогенезе депрессивных расстройств, сердечно-сосудистых заболеваний и сахарного диабета. Предложен эксклюзивный метод коррекции дефицита магния при помощи разработанного авторами суплемента Оптинерв. Намечены дальнейшие пути более детального исследования молекулярных меха­низмов добавок магния в качестве суплемента, как мультицентровое международное исследование.

Ключевые слова


магний; депрессивные расстройства; сердечно-сосудистые заболевания; сахарный диабет; суплементы магния; Оптинерв

Полный текст:

Литература


Бегма, А. Н. Коррекция метаболических нарушений у пациентов сахарным диабетом в лечении дистальной полинейропатии / А. Н. Бегма, И. В. Бегма // Трудный пациент. - 2012. - T. 10. - № 4. - С. 33-37.

Говорин, А. В. Препараты магния при заболеваниях сердечно-сосудистой системы / А. В. Говорин, А. П. Филёв // Актуальные вопросы клинической фармакологии. - 2012. - № 8. - С. 463-468.

Aarts, M. M. TRPM7 and ischemic CNS injury / M. M. Aarts, M. Tymianski // Neuroscientist. - 2005. - № 11(2). - P. 116-123.

Abaamrane, L. Long-term administration of magnesium after acoustic trauma caused by gunshot noise in guinea pigs / L. Abaamrane [et al.] // Hear Res. - 2009. - Vol. 247. - P. 137-145.

Altura, B.M. Low extracellular magnesium ions induce lipid peroxidation and activation of nuclear factor-kappa B in canine cerebral vascular smooth muscle: possible relation to traumatic brain injury and strokes / B. M. Altura [et al.] // Neurosci Lett. - 2003. - Vol. 341. - № 3. - P. 189-192.

Altura, B. M. Role of brain [Mg2+] in alcohol-induced hemorrhagic stroke in a rat model: a 31P-NMR in vivo study / B. M. Altura [et al.] // Alcohol. - 1995. - № 12. - P. 131-136.

Altura, B. M. Short-term magnesium deficiency upregulates sphingomyelin synthase and p53 in cardiovascular tissues and cells: relevance to the de novo synthesis of ceramide / B. M. Altura [et al.] // Am J Physiol. Heart and Circulatory physiology. - 2010. - Vol. 299. - № 6. - P. 2046-2055.

Altura, B. M. Short-term Mg deficiency upregulates proteinkinase C isoforms in cardiovascular tissues and cells; relation to NF-kB, cytokines, ceramide salvage sphingolipid pathway and PKC-zeta: hypothesis and review / B.M. Altura [et al.] // Intern J Clin Exp Med. - 2014. - № 7. - P. 1-21.

Amyard, N. Brain catecholamines, serotonin and their metabolites in mice selected for low (MGL) and high (MGH) blood magnesium levels / N.Amyard [et al.] // Magnes Res. - 1995. - № 8. - P. 5-9.

Banki, C. M. Aminergic studies and cerebrospinal fluid cations in suicide / C. M. Banki, M. Arató, C. D. Kilts // Ann N Y Acad Sci. - 1986. - Vol. 487. - P. 221-230.

Banki, C. M. Cerebrospinal fluid magnesium and calcium related to amine metabolites, diagnosis, and suicide attempts / C. M. Banki [et al.] // Biol Psychiatry. - 1985. - Vol. 20. - № 2. - P. 163-171.

Bara, M. Potassium, magnesium and membranes. Review of present status and new findings / M. Bara, A. Guiet- Bara // Magnesium. - 1984. - № 3. - P. 215-225.

Barbagallo, M. Magnesium and aging / M. Barbagallo, L. J. Dominguez // Curr Pharm Des. - 2010. - Vol. 16. - № 7. - P. 832-839.

Barragán-Rodríguez, L. Efficacy and safety of oral magnesium supplementation in the treatment of depression in the elderly with type 2 diabetes: a randomized, equivalent trial / L. Barragán-Rodríguez, M. Rodríguez-Morán, F. Guerrero- Romero // Magnes Res. – 2008. - Vol. 21. - № 4. - P. 218-223.

Bear, M. F. Neurotransmitter Systems / M. F. Bear, B. W. Connors, M. A. // Paradiso In: Neuroscience Exploring the brain, 2nd ed. - Baltimore MD, Lippincot Williams and Wilkins, 2001. - P. 131-162.

Berman, R. M. Antidepressant effects of ketamine in depressed patients / R. M. Berman [et al.] // Biol Psychiatry. - 2000. - Vol. 47. - № 4. - P. 351-354.

Billard, J. M. Ageing, hippocampal synaptic activity and magnesium / J. M. Billard // Magnes Res. - 2006. - Vol. 19. - № 3. - P. 199-215.

Blaylock, R. L. Food additive excitotoxins and degenerative brain disorders / R. L. Blaylock // Medical Sentinel. - 1999. - № 4. - P. 212-214.

Caddell, J. Plasma catecholamines in acute magnesium deficiency in weanling rats / J. Caddell [et al.] // J Nutr. - 1986. - Vol. 116. - № 10. - P. 1896-1901.

Calderon, R.L. Draft for review and comments. Water hardness and cardiovascular disease: A review of epidemiological studies 1957-79 / R. L. Calderon, G. F. Craun // Rolling Revision of the WHO Guidelines for Drinking-Water Quality. - World Health Organization, August 2004. - 18 p.

Carafoli, E. Calcium-a universal carrier of biological signals / E. Carafoli // FEBS J. - 2005. - Vol. 272. - № 5. - P. 1073-1089.

Chaudhary, D. P. Implications of magnesium deficiency in type 2 diabetes: a review / D.P. Chaudhary, R. Sharma, D. Bansal // Biol Trace Elem Res. - 2010. - Vol. 134. - P. 119-129.

Cox, I. M. Red blood cell magnesium and chronic fatigue syndrome / I. M. Cox, M. J. Campbell, D. Dowson // Lancet. - 1991. - Vol. 337 (8744). - P. 757-760.

Cratty, M. S. N-methyl-D-aspartate (NMDA)-mediated corticotropin-releasing factor (CRF) release in cultured rat amygdala neurons / M. S. Cratty, D.L. Birkle // Peptides. – 1999. - Vol. 20. - № 1. - P. 93-100.

Dasgupta, A. Hypomagnesemia in type 2 diabetes mellitus/ A. Dasgupta, D. Sarma, U.K. Saikia // Indian J Endocrinol Metab. – 2012. - Vol. 16. - № 5. - P. 1000–1003.

Dayas, C. V. Effects of chronic oestrogen replacement on stress-induced activation of hypothalamic-pituitary-adrenal axis control pathways / C.V. Dayas [et al.] // J Neuroendocrinol. - 2000. - Vol. 12. - № 8. - P. 784-794.

Dong, J.F. Magnesium maintains endothelial integrity, up-regulates proteolysis of ultra-large von Willebrand factor, and reduces platelet aggregation under flow conditions / J. F. Dong [et al.] // Thromb Haemost. - 2008. - Vol. 99. - № 3. - P. 586-593.

Eby, G.A. Rapid recovery from major depression using magnesium treatment/ G. A. Eby, K. L. Eby // Med Hypotheses. - 2006. - Vol. 67. - № 2. - P. 362-370.

Enya, M. Depressive state and paresthesia dramatically improved by intravenous MgSO4 in Gitelman’s syndrome / M. Enya [et al.] // Intern Med. - 2004. - Vol. 43. - № 5. - P. 410-414.

Fekadu, A. The Maudsley Staging Method for treatment-resistant depression: prediction of longer-term outcome and persistence of symptoms / A. Fekadu [et al.] // J Clin Psychiatry. - 2009. - Vol. 70. - № 7. - P. 952-957.

Fekadu, A. A multidimensional tool to quantify treatment resistance in depression: the Maudsley staging method / A. Fekadu [et al.] // J Clin Psychiatry. - 2009. - Vol.70. - № 2. - P. 177-184.

Fekadu, A. What happens to patients with treatment-resistant depression? A systematic review of medium to long term outcome studies / A.Fekadu [et al.] // J Affect Disord. - 2009. - Vol. 116. - № 1-2. - P. 4-11.

Franz, K. B. A functional biological marker is needed for diagnosing magnesium deficiency / K. B. Franz // J Am Coll Nutr. – 2004. - Vol. 23. - P. 738-741.

Grubbs, R. D. Magnesium as a regulatory cation: criteria and evaluation / R. D. Grubbs, M.E. Maguire // Magnesium. - 1987. - Vol. 6. - № 3. - P. 113-127.

Gьnther, T. Regulation of intracellular magnesium by Mg2+ efflux / T. Gьnther, J. Vormann, R. Fцrster // Biochem Biophys Res Commun. - 1984. - Vol. 119. - P. 124-131.

Henrotte, J. G. Mice selected for low and high blood magnesium levels: a new model for stress studies / J. G. Henrotte [et al.] // Physiol Behav. - 1997. – Vol. 61. - № 5. - P. 653-658.

Iosifescu, D. V. An open study of triiodothyronine augmentation of selective serotonin reuptake inhibitors in treatment-resistant major depressive disorder / D. V. Iosifescu [et al.] // J Clin Psychiatry. - 2005. - Vol. 66. - № 8. - P. 1038- 1042.

Iotti, S. Inorganic phosphate is transported into mitochondria in the absence of ATP biosynthesis: an in vivo 31P NMR study in the human skeletal muscle / S. Iotti [et al.] // Biochem Biophys Res Commun. - 1996. - Vol. 225. - P. 191-194.

Jшrgensen, H. S. Studies on the neuroendocrine role of serotonin / H. S. Jшrgensen/ / Dan Med Bull. - 2007. - Vol. 54. - № 4. - P. 266-288.

Kandal, E. R. Synaptic integration / E.R. Kandal, J. H.Schwarz, T. M. Jessel // In: Essentials of neural science and behaviour. - Stamford, Appleton & Lange, 1995. - P. 219-241.

Khan, A. M. Low serum magnesium and the development of atrial fibrillation in the community: the Framingham Heart Study / A. M. Khan [et al.] // Circulation. - 2013. - Vol. 127. - P. 33-38.

Kundu, D. Serum magnesium levels in patients with diabetic retinopathy / D. Kundu [et al.] // J Nat Sci Biol Med. - 2013. - Vol. 4. - № 1. - P. 113–116.

Langley, W. F. Central nervous system magnesium deficiency / W. F. Langley, D. Mann // Arch Intern Med. - 1991. - Vol. 151. - P. 593-596

Lapik, I. A. Assessment of efficiency of dietotherapy with addition of a vitamin-mineral complex in patients with diabetes mellitus type 2 / I.A. Lapik [et al.] // Vopr Pitan. - 2014. - Vol. 83. - № 3. - P. 74-81.

Levine, J. High serum and cerebrospinal fluid Ca/ Mg ratio in recently hospitalized acutely depressed patients / J. Levine [et al.] // Neuropsychobiology. – 1999. - Vol. 39. - № 2. - P. 63-70.

Lipton, S.A. Excitatory amino acids as a final common pathway for neurologic disorders / S.A. Lipton, P.A. Rosenberg // N Engl J Med. - 1994. - Vol. 330. - № 9. - P. 613-622.

Machado-Vieira, R. Ketamine and the next generation of antidepressants with a rapid onset of action / R. Machado- Vieira [et al.] // Pharmacol Ther. - 2009. - Vol. 123. - № 2. - P. 143-150.

Magalhaes, A.C. CRF receptor 1 regulates anxiety behavior via sensitization of 5-HT2 receptor signaling / A. C. Magalhaes [et al.] // Nat Neurosci. - 2010. - Vol. 13. - № 5. - P. 622-629.

Mark, L.P. Pictorial review of glutamate excitotoxicity: fundamental concepts for neuroimaging / L.P. Mark [et al.] // Am J Neuroradiol. - 2001. - Vol. 22. - P. 1813-1824.

McMenimen, K. A. Probing the Mg2+ blockade site of an N-methyl-D-aspartate (NMDA) receptor with unnatural amino acid mutagenesis / K.A. McMenimen [et al.] // ACS Chem Biol. - 2006. - Vol. 1. - № 4. - P. 227-234.

Mizoguchi, K. Persistent depressive state after chronic stress in rats is accompanied by HPA axis dysregulation and reduced prefrontal dopaminergic neurotransmission / K. Mizoguchi [et al.] // Pharmacol Biochem Behav. - 2008. - Vol. 91. - № 1. - P. 170-175.

Murck, H. Magnesium and affective disorders / H. Murck // Nutr Neurosci. - 2002. - Vol. 5. - № 6. - P. 375-389.

Nierenberg, A. A. Residual symptoms after remission of major depressive disorder with citalopram and risk of relapse: a STAR*D report / A.A. Nierenberg [et al.] // Psychol Med. – 2010. – Vol. 40. - № 1. - P. 41-50.

Nowak, G. Magnesium and Glutamate interaction in depression and antidepressant therapy / G. Nowak [et al.] // Biological Psychiatry. - 2010. - Vol. 67. - P. 195.

Phelps, L. E. Family history of alcohol dependence and initial antidepressant response to an N-methyl-D-aspartate antagonist / L.E. Phelps [et al.] // Biol Psychiatry. - 2009. - Vol. 65. - № 2. - P. 181-184.

Pittaluga, A. Somatostatin potentiates NMDA receptor function via activation of InsP(3) receptors and PKC leading to removal of the Mg(2+) block without depolarization / A. Pittaluga, A. Bonfanti, M. Raiteri // Br J Pharmacol. - 2000. - Vol. 130. - № 3. - P. 557-566.

Popkin, B. M. Global nutrition dynamics: the world is shifting rapidly toward a diet linked with noncommunicable diseases / B. M. Popkin // Am J Clin Nutr. - 2006. - Vol. 84. - № 2. - P. 289-298.

Qu, X. Magnesium and the risk of cardiovascular events: a meta-analysis of prospective cohort studies / X. Qu [et al.] // PLoS One. - 2013. - Vol. 8. № 3. - P. e57720.

Rayssiguier, Y. Magnesium deficiency and metabolic syndrome: stress and inflammation may reflect calcium activation / Y. Rayssiguier [et al.] // Magnes Res. - 2010. - Vol. 23. - № 2. - P. 73–80.

Rego, A. C. Mitochondrial dysfunction and reactive oxygen species in excitotoxicity and apoptosis: implications for the pathogenesis of neurodegenerative diseases / A. C. Rego, C. R. Oliveira // Neurochem Res. - 2003. - Vol. 28. - № 10. - P. 1563-1574.

Rodraguez, M. Magnesium its role in CKD / M. Rodrнguez // Nefrologia: publicacion oficial de la Sociedad Espanola Nefrologia. - 2013. - Vol. 33. - № 3. - P. 389-399.

Rosanoff, A. Suboptimal magnesium status in the United States: are the health consequences underestimated? / A. Rosanoff, C. M. Weaver, R. K. Rude // Nutr Rev. - 2012. - Vol. 70. - № 3. - P. 153–164.

Sapolsky, R. M. Stress the aging brain and the mechanisms of neuron death / R.M. Sapolsky. - Cambridge, MA, A. Bradford Book, the MIT Press, 1992. - 192 p.

Saris, N. E. Magnesium. An update on physiological, clinical and analytical aspects / N. E. Saris [et al.] // Clin Chim Acta. - 2000. - Vol. 294. - № 1-2. - P. 1-26.

Sartori, S. B. Magnesium deficiency induces anxiety and HPA axis dysregulation: modulation by therapeutic drug treatment / S. B. Sartori [et al.] // Neuropharmacology. - 2012. - Vol. 62. - № 1. - P. 304-312.

Schmitz, C. Regulation of vertebrate cellular Mg2+ homeostasis by TRPM7 / C. Schmitz [et al.] // Cell. - 2003. - Vol. 114. - № 2. - P. 191-200.

Seelig, M.S. Consequences of magnesium deficiency on the enhancement of stress reactions; preventive and therapeutic implications (a review) / M. S. Seelig // J Am Coll Nutr. - 1994. - Vol. 13. - № 5. - P. 429-446.

Soma, M. Effects of low magnesium diet on the vascular prostaglandin and fatty acid metabolism in rats / M. Soma [et al.] // Prostaglandins. - 1988. - Vol. 36. - № 4. - P. 431-441.

Sontia, B. Role of magnesium in hypertension / B. Sontia, R. M. Touyz // Arch Biochem Biophys. - 2007. - Vol. 458. - № 1. - P. 33-39.

Szewczyk, B. Antidepressant activity of zinc and magnesium in view of the current hypotheses of antidepressant action / B. Szewczyk [et al.] // Pharmacol Rep. - 2008. - Vol. 60. - № 5. - P. 588-589.

Tietz, N. W. Clinical Guide to Laboratory Tests / N. W. Tietz. - 3rd Edition WB Saunders Company, Philadelphia, PA, 1995. - 374 p.

Topf, J. M. Hypomagnesemia and hypermagnesemia / J. M. Topf, P. T. Murray // Rev Endocr Metab Disord. - 2003. - Vol. 4. - P. 195–206.

Turgut, F. Magnesium supplementation helps to improve carotid intima media thickness in patients on haemodialysis / F. Turgut [et al.] // Intern. Urology and Nephrology. - 2008. - Vol. 40. - № 4. - P. 1075-1082.

Vink, R. Decline in intracellular free Mg2+ is associated with irreversible tissue injury after brain trauma / R. Vink [et al.] // J Biol Chem. - 1988. - Vol. 263. - № 2. - P. 757-761.

Weglicki, W. B. Cytokines, neuropeptides, and reperfusion injury during magnesium deficiency / W. B. Weglicki [et al.] // Ann N Y Acad Sci. -1994. - Vol. 17. - № 723. - P. 246-257.

Whyte, K.F. Adrenergic control of plasma magnesium in man / K. F. Whyte [et al.] // Clin Sci (Lond). - 1987. - Vol. 72. - № 1. - P. 135-138.

Wolf, M. Interaction of proteinkinase C with membranes is regulated by Ca2+, phorbol esters, and ATP / M. Wolf, P. Cuatrecasas, N. Sahyoun // J Biol Chem. – 1985. - Vol. 260. - № 29. - P. 15718-15722.

Wolf, F.I. Magnesium deficiency affects mammary epithelial cell proliferation: involvement of oxidative stress / F. I. Wolf [et al.] // Nutr Cancer. - 2009. - Vol. 61. - № 1. - P. 131-136.

World Health Report. Changing history annex table 3: burden of disease in DALYs by cause, sex and mortality stratum in WHO regions estimates for 2002. - Geneva: The World Health Organization, 2004.

Yasui, M. Effects of low calcium and magnesium dietary intake on the central nervous system tissues of rats and calcium-magnesium related disorders in the amyotrophic lateral sclerosis focus in the Kii Peninsula of Japan / M. Yasui, K. Ota, M. Yoshida // Magnes Res. - 1997. - Vol. 10. - № 1. - P. 39-50.

Zarate, C. A. A randomized trial of an N-methyl-D-aspartate antagonist in treatment-resistant major depression / C. A. Zarate [et al.] // Arch Gen Psychiatry. - 2006. - Vol. 63. - № 8. - P. 856-864.


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