АЛКОГОЛЬНЫЙ СИНДРОМ ПЛОДА




Е. И. Бонь (Bon E. I.), С. М. Зиматкин (Zimatkin S. M.)

Аннотация


В обзоре обобщены данные литературы о нарушениях в организме плода, возникающих под воздействием пренатальной алкоголизации, о критериях диагностики, патогенезе, нарушениях поведения, о лечении и профилактике фетального алкогольного синдрома (ФАС). Основным проявлением ФАС является повреждение центральной нервной системы, особенно головного мозга. Развитие и созревание клеток и структур мозга нарушается при пренатальном воздействии алкоголя, и это может стать причиной первичных когнитивных и функциональных нарушений (в том числе нарушений памяти, дефицита внимания, импульсивного поведения и логического мышления), а также вторичных нарушений (например, предрасположенности к проблемам психического здоровья и наркомании). Воздействие алкоголя представляет угрозу повреждения мозга плода на любом сроке беременности, так как развитие мозга продолжается в течение всей беременности.


Ключевые слова


фетальный алкогольный синдром; центральная нервная система

Полный текст:

Литература


Abel, E.L. A review of alcohol’s effects on sex and reproduction / E.L. Abel // Drug Alcohol Depend. – 1980. – V. 5. – P. 321-332.

Abel, E.L. Fetal alcohol syndrome is now leading cause of mental retardation / E.L. Abel, R.J. Sokol // Lancet. - 1986. – V. 8517. - Р. 1222-1228.

Abel, E.L. In utero alcohol exposure and development delay of response inhibition / E.L. Abel // Alcoholism. – 1982. – V. 6. – P.369-376.

Abel, E.L. In utero alcohol exposure. Functional and structural brain damage / E.L. Abel, S. Jacobsen, B.T. Sherwin // Neurobeh. Toxicology and Teratology. – 1983. – V. 5. – P.363-366.

Abel, E.L. Prenatal effects of alcohol / E.L. Abel // Drug Alcohol Depend. – 1984. – V. 14. – P. 1-10.

Abel, E.L. Ptenatal effects of alcohol on growth: a brief overview / E.L. Abel // Fed. Proc. – 1985. – V. 44. – P. 2318-2322.

Ahlgren, S.C. Sonic hedgehog rescues cranial neural crest from cell death induced by ethanol exposure / S.C. Ahlgren, V. Thakur, M. Bronner-Fraser // ProcNatlAcadSci U S A. – 2002. – V. 99. – P. 10476-10481.

Akbar, M. Protective effects of docosahexaenoic acid in staurosporine-induced apoptosis: involvement of phosphatidylinositol-3 kinase pathway / M. Akbar, HY. Kim // J Neurochem. – 2002. – V. 82. – P. 655-665.

Arevalo, E. An alcohol binding site on the neural cell adhesion molecule L1 / E. Arevalo, S. Shamugasundararaj, M.F. Willemeyer // Proceedings of the National Academy of Sciences of the United States of America. - 2008. – V. 105. – P.371-375.

Aronne, M.P. A case definition and photographic screening tool for the facial phenotype of fetal alcohol syndrome / M.P. Aronne, S.K. Clarren // Journal of Pediatrics. – 1996. – V.129. – P. 33-41.

Aronne, M.P. Effects of prenatal ethanol exposure on rat brain radial glia and neuroblast migration / M.P. Aronne // Exp Neurol. – 2011. - V. 229 – P. 71-83.

Aronne, M.P. NAP (davunetide) provides functional and structural neuroprotection / M.P. Aronne, I. Gozes // Curr Pharm Des. – 2011. – V. 17. – P. 44-53.

Assadi, F.K. Impaired renal acidification in infants with fetal alcohol syndrome / F.K. Assadi, M. Ziai // Pediatr Res. – 1985. – V. 19. – P. 850-853.

Assadi, F.K. Renal tubular dysfunction in fetal alcohol syndrome / F.K. Assadi // PediatrNephrol. – 1990. – V. 4. – P.48-51.

Assadi, F.K. Ultrastructural changes in the rat kidney following fetal exposure to ethanol / F.K. Assadi, C.S. Zajac // Alcohol. – 1992. – V. 9. – P. 509-512.

Astley, S.J. A case definition and photographic screening tool for the facial phenotype of fetal alcohol syndrome / S.J. Astley, S.K. Clarren // J Pediatr. – 1996. – V. 129. – P. 33-41.

Astley, S.J. Measuring the facial phenotype of individuals with prenatal alcohol exposure: correlations with brain dysfunction / S.J. Astley, S.K. Clarren // Alcohol Alcohol. – 2001. – V. 36. – P. 147-159

Aufrere, G. Effect of alcohol intoxication during pregnancy on foetal and placental weight: experimental studies / G. Aufrere, B. Le Bourhis // AlcoholAlcohol. – 1987. – V.22. – P. 401-407.

Baghurst, K.I. The effect of high alcohol intake on nutritional status and health outcome / K.I. Baghurst // AustFam Physician. – 1982. – V. 11. – P. 259-262.

Balaraman, S. Opposing Actions of Ethanol and Nicotine on MicroRNAs are Mediated by Nicotinic Acetylcholine Receptors in Fetal Cerebral Cortical-Derived Neural Progenitor Cells / S. Balaraman, U.H. Winzer-Serhan, R.C. Miranda // AlcoholClinExp Res. – 2012. - V. 1111. – P. 1530-1539.

Baruah, J.K. Pathological changes in peripheral nerves in experimental fetal alcohol syndrome / J.K. Baruah, D. Kinder // AlcoholClinExp Res. – 1989. – V. 13. – P. 547-550.

BDNF and NGF afford in vitro neuroprotection against ethanol combined with acute ischemia and chronic hypoglycemia / J.J. Mitchell [et al.] // Developmental Neuroscience. - 1999. – V. 21. – P. 68-75.

Beal, M.F. Oxidative damage in neurodegenerative diseases / M.F. Beal // Neuroscientist. – 1997. –V. 3. – P. 21-27.

Beauchemin, R.R. Alcohol induced cardiac malformations in the rat / R.R. Beauchemin, L.P. Gartner, D.V. Provenza // AnatAnz. – 1984. – V. 155. – P. 17-28.

Bertrand, J. Consortium IfCwFASDR. Interventions for children with fetal alcohol spectrum disorders (FASDs): overview of findings for five innovative research projects / J. Bertrand // Res DevDisabil. – 2009. – V. 30. – P. 986-1006.

Bhalla, S. Effect of prenatal exposure to ethanol on postnatal development of intestinal transport functions in rats / S. Bhalla, S. Mahmood, A. Mahmood // Eur J Nutr. – 2004. – V.43. – P. 109-115.

Bing, R.J. Effect of alcohol on the heart and cardiac metabolism / R.J. Bing // Fed Proc. – 1982. – V. 41. – P. 2443-2446.

Bodiazhina, V.I. Anti-alcohol propaganda for preventing developmental defects in progeny / V.I. Bodiazhina // AkushGinekol (Mosk). – 1986. – V. 3. – P. 3-5.

Breese, C.R. Effect of ethanol on plasma and hepatic insulin-like growth factor regulation in pregnant rats / C.R. Breese, W.E. Sonntag // AlcoholClinExp Res. – 1995. – V. 19. – P. 867-873.

Bristol, R.E. Normally shaped heads with no sutures, normally shaped heads with abnormal sutures, and abnormally shaped heads with normal sutures / R.E. Bristol, M.D. Krieger, J.G. McComb // J Craniofac Surg. – 2011. – V. 22. – P. 173-177.

Bucens, I.K. Isospora belli infection and chronic electrolyte disturbance in a child with fetal alcohol syndrome / I.K. Bucens, R.O. King // Med J Aust. - 2000. - V. 173. - P.252-255.

Buts, J.P. Prenatal exposure to ethanol in rats: effects on postnatal maturation of the small intestine and liver / J.P. Buts, E.M. Sokal, F. Van Hoof // Pediatr Res. – 1992. – V. 32. – P.574-579

Caley, L.M. Results of a nurse-led workshop designed to prevent fetal alcohol spectrum disorder / L.M. Caley, S. Riemer, H.S. Weinstein // Public Health Nurs. – 2010. – V. 27.– P. 232-239.

Chávez Rivera, I. Alcohol and the cardiovascular system. (1) Alcoholic intoxication / I. Chávez Rivera, C.L. Fernández Barros // Arch InstCardiol Mex. – 1985. – V. 55. – P.165-182.

Chen, S. Ethanol disrupts axon outgrowth stimulated by netrin-1, GDNF, and L1 by blocking their convergent activation of Src family kinase signaling / S. Chen, M.E. Charness // J Neurochem. – 2012. – V. 10. – P. 1471-4159.

Chen, W.J. Zinc supplementation does not attenuate alcohol-induced cerebellar Purkinje cell loss during the brain growth spurt period / W.J. Chen, E.C. Berryhill, J.R. West // Alcohol ClinExp Res. – 2001. – V. 25. – P. 600-605.

Choi, I.Y. Moderate fetal alcohol exposure impairs the neurogenic response to an enriched environment in adult mice / I.Y. Choi, A.M. Allan, L.A. Cunningham // Alcoholism: Clinical and Experimental Research. - 2005. – V. 29. – P. 2053-2062.

Christie, B.R. Voluntary exercise rescues deficits in spatial memory and long-term potentiation in prenatal ethanol exposed male rats / B.R. Christie, S.E. Swann, C.J. Fox // European Journal of Neuroscience. - 2005. – V. 21. – P. 1719-1726,

Harris, S.J. Exposure of rats to a high but not low dose of ethanol during early postnatal life increases the rate of loss of optic nerve axons and decreases the rate of myelination / S.J. Harris, P. Wilce, K.S. Bedi // J Anat. – 2000. – V. 197. – P.477-485.

Heaton, M.B. Amelioration of ethanol-induced neurotoxicity in the neonatal rat central nervous system by antioxidant therapy / M.B. Heaton, J.J. Mitchell, M. Paiva // AlcoholClinExp Res. – 2000. - V. 24. – P. 512-518.

Kim, H.Y. Effects of docosapentaenoic acid on neuronal apoptosis / H.Y. Kim, M. Akbar, A. Lau // Lipids. – 2003. – V.38. – P. 453-457.

Kleiber, M.L. Maternal voluntary drinking in C57BL/6J mice: advancing a model for fetal alcohol spectrum disorders / M.L. Kleiber, E. Wright, S.M. Singh // Behav Brain Res. – 2011. – V. 223. – P. 376-387.

Klein, H. Perceived consequences associated with the use of beer, wine, distilled spirits, and wine coolers / H. Klein, D.J. Pittman // Int J Addict. – 1990. – V. 25. – P. 471-493.

Klintsova, A.Y. Therapeutic effects of complex motor training on motor performance deficits induced by neonatal binge-like alcohol exposure in rats: II. a quantitative stereological study of synaptic plasticity in female rat cerebellum / A.Y. Klintsova, C. Scamra, M. Hoffman // Brain Research. - 2002. – V. 937. – P. 83-93.

Klintsova, A.Y. Therapeutic motor training ameliorates cerebellar effects of postnatal binge alcohol / A.Y. Klintsova, C.R. Goodlett, W.T. Greenough // Neurotoxicology and Teratology. - 2000. – V. 22. – P. 125-132.

Lang, J. Ten Brain Domains: A Proposal for Functional Central Nervous System Parameters for Fetal Alcohol Spectrum Disorder Diagnosis and Follow-up / J. Lang // Journal of the FAS Institute. – 2006. – V.4. – P. 11-14.

Lawrence, R.C. Selective effects of perinatal ethanol exposure in medial prefrontal cortex and nucleus accumbens /R.C. Lawrence, N.K. Otero, S.J. Kelly // NeurotoxicolTeratol. - 2012. – V. 34. – P. 128-135.

Le Bourchis, B. Effect of perinatal intoxication on preference to ethanol et adult stage in rat / B. Le Bourchis, G. Aufrere, D. Choquart // Third. Congress Int. Soc. Biomed. Res. On Alcoholism. – Fergamon Press, 1986.–– Abstr. 162.

Lee, J.H. Effects of ethanol and ipsapirone on the expression of genes encoding anti-apoptotic proteins and an antioxidant enzyme in ethanol-treated neurons / J.H. Lee, N.F. Tajuddin, M.J. Druse // Brain Research. - 2009. – V. 1249 – P.54-60.

Lee, S. Gender differences in the effect of prenatal alcohol exposure on the hypothalamic-pituitary-adrenal axis response to immune signals / S. Lee, C. Rivier // Psychoneuroendocrinology. – 1996. – V. 21. – P. 145-55.

Tsai, G. The role of glutamatergic neurotransmission in the pathophysiology of alcoholism / G.Tsai, J.T. Coyle // Annual Review of Medicine. - 1998. – V. 49. – P. 173-184.

Twal, W.O. Retinoic acid reverses ethanol-induced cardiovascular abnormalities in quail embryos / W.O. Twal, M.H. Zile // AlcoholClinExp Res. - 1997. - V. 21(6). - P. 1137-1143.

Ullah, N. Protective effect of pyruvate against ethanol- induced apoptotic neurodegeneration in the developing rat brain / N. Ullah, M.I. Naseer, I. Ullah // Neuropharmacology. – 2011. – V. 61. – P. 1248-1255.

Ullan, I. Neuroprotection with metformin and thymoquinone against ethanol-induced apoptotic neurodegeneration in prenatal rat cortical neurons / I. Ullah, H.Y. Lee, M.O. Kim // BMC Neurosci. – 2012. – V. 14 – P. 123-125.

Ulllrich, K. A contribution to the postnatal enzymatic state of maturity of gyrus hippocampi in the embryofetal alcohol syndrome of the rat / K. Ulllrich, K. Dietzmen // Experimental Pathology. – 1980. – V. 18. – P. 170-174.

Uphoff, C. Cardiac muscle development in mice exposed to ethanol in utero / C. Uphoff, C. Nyquist-Battie, R. Toth // Teratology. – 1984. – V. 30. – P. 119-129.

Usowicz, A.G. Upper airway obstruction in infants with fetal alcohol syndrome / A.G. Usowicz, M. Golabi, C. Curry // Am J Dis Child. – 1986. – V. 140. – P. 1039-1041.

Uthoff, K. Proximal radioulnarsynostosis within the scope of fetal alcohol syndrome / K. Uthoff, U. Bosch // Unfallchirurg. – 1997. – V. 100. – P. 678-682.

Uzbekov, M.G. Activity of Zn-, Cu-containing superoxide dismutase in the brain tissue of rats with fetal alcohol syndrome / M.G. Uzbekov, I.K. Karpachevskaia // Eksperimental Biology Medicine. – 1991. - V. 111. – P. 354- 358.


Ссылки

  • На текущий момент ссылки отсутствуют.