РОЛЬ НАРУШЕНИЙ ПРОЦЕССОВ МЕТИЛИРОВАНИЯ И ОБМЕНА МЕТИОНИНА В ПАТОГЕНЕЗЕ ЗАБОЛЕВАНИЙ ЧЕЛОВЕКА

  • А. В. Наумов УО "Гродненский государственный медицинский университет"
Ключевые слова: метионин, гомоцистеин, S-аденозилметионин, эпигенез, шизофрения, болезнь Альцгеймера, системная эритематозная волчанка

Аннотация

Процессы метилирования играют важнейшую роль в жизни всего живого - от вирусов до человека. Они не только участвуют в синтезе важных соединений, например, пуринов, полиаминов, фосфолипидов, креатина, мелатонина, но и служат широко распространённым регуляторным механизмом, определяющим функции бел­ков, фосфолипидов и ДНК. Метилирование ДНК формирует эпигеном и определяет его реализацию без изменения генетического кода. В патогенезе заболеваний человека участвуют как промежуточные метаболиты процесса метилирования (гомоцистеин), так и нарушения метилирования белков и эпигенетического кода. Эти процессы очень чувствительны к действию разнообразных внешних факторов и в последние годы им уделяется самое пристальное внимание.

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Наумов АВ. РОЛЬ НАРУШЕНИЙ ПРОЦЕССОВ МЕТИЛИРОВАНИЯ И ОБМЕНА МЕТИОНИНА В ПАТОГЕНЕЗЕ ЗАБОЛЕВАНИЙ ЧЕЛОВЕКА. Журнал ГрГМУ (Journal GrSMU) [Интернет]. 4 ноябрь 2015 г. [цитируется по 14 июнь 2024 г.];(1(17):4-. доступно на: http://journal-grsmu.by/index.php/ojs/article/view/1164

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