АЛКОГОЛЬНЫЙ И НЕАЛКОГОЛЬНЫЙ СТЕАТОГЕПАТИТ: РАЗЛИЧИЯ, СХОДСТВО И ПОПЫТКА СТЕРЕТЬ ГРАНИЦЫ МЕЖДУ ЭТИМИ ЗАБОЛЕВАНИЯМИ
Аннотация
Целью настоящего обзора является анализ литературных данных, указывающих на сходство и различие патогенетических механизмов алкогольного и неалкогольного стеатогепатитов. Установление различий между этими заболеваниями в настоящее время затруднено их гистологическим сходством и общностью патогенетических механизмов. В то же время базирование различий на факторах риска представляется достаточно субъективным. Подчёркивается необходимость дальнейших экспериментальных и клинических исследований по данной проблеме.
Литература
The dose-dependent beneficial effect of ursodeoxycholic acid in rats with non-alcoholic steatohepatitis induced by methionine and choline deficient diet / V.U. Buko [et al.] // Альманах «Здоровье и питание». – Минск, 2005. – С. 46–52.
Approach to the pathogenesis and treatment of nonalcoholic steatohepatitis / J. Medina [et al.] // Diabetes Care. – 2004. Vol. 27 – P. 2057–2066.
Bellentani, S. The spectrum of liver diseases in the general population: from the Dionisios study/ S. Bellentani , C. Tiribelli // J. Hepatol. – 2001. – Vol. 35. – P. 531–537.
Day, C.P. Steatohepatitis: a tale of two hits? / C.P. Day, OFW. James // Gastroenterology. – 1998. – Vol. 114. – P. 842– 845.
Day, C.P. Genes or environment to determine alcoholic liver disease and non-alcoholic liver disease / C.P. Day // Liver Inter. – 2006. – Vol. 26. – P. 1021–1026.
Depot-specific hormonal characteristics of subcutaneous and visceral adipose tissue and their relation to the metabolic syndrome / B.L.Wajchenberg [et al.] // Horm Metab Res. – 2002. – Vol. 34, №11/12. – P. 616–621.
Diehl, A.M. Obesity and alcoholic liver disease / A.M. Diehl //Alcohol. – 2004. – Vol. 34, № 1. – P. 181–187.
El-Sharag, H.B. The role of diabetes in hepatocellular carcinoma / H.B. El-Sharag, P.A. Richardson, J.E. Everhart // Am J. Gastroenterol. – 2001. – Vol. 96. – P. 2462–2467.
Excess weight risk factor for alcoholic liver disease / S. Naveau [et al.] // Hepatology. – 1997. – Vol.25. – P. 108–111.
Hepatic injury associated with small bowel bacterial overgrowth in rats is prevented by metronidazole and tetracycline / S.N. Lichtman [et al.] // Gastroenterology. – 1991. – Vol.100, № 2. – P. 513–519.
Hypoadiponectinemia and insulin resistance are associated with nonalcoholic fatty liver disease/ D.Yoon [et al.] // J. Korean Med Sci. – 2005. – Vol. 20, № 3. – P. 421–426.
Impairment of the intestinal barrier by ethanol involves enteric microflora and mast cell activation in rodents / L. Ferrier [et al.] // Am J. Pathol. – 2006. – Vol. 68, № 4. – P. 1148–1154.
Increased gastrointestinal ethanol production in obese mice: implications for fatty liver disease pathogenesis / K. Cope [ et al.] // Gastroenterology. – 2000. – Vol. 119, № 5. – P. 1340–1347.
Influence of alcohol consumption and various beverages on waist girth and waist-to-hip ratio in a sample of French men and women / J. Dallongeville [et al.] // Int J. Obes Relat Metab Disord. – 1998. – Vol.22, № 12. – P. 1178–1183.
Insulin resistance accelerates a dietary rat model of nonalcoholic steatohepatitis / T. Ota [et al.] // Gastroenterology. – 2007. – Vol.132, № 1. – P. 282–293.
Lieber, C.S. Alcoholic fatty liver: Its pathogenesis and mechanism of progression to inflammation and fibrosis / C.S. Lieber // Alcohol. – 2004. – Vol. 34. – P. 9–19.
Lonardo, A. Of liver, whisky and plants: a requiem of colchicines in alcoholic cirrhosis? / A. Lonardo, P. Loria // Eur J. Gastroenterol Hepatol. – 2002. – Vol. 14. – P. 355–358.
Marotta, F. Experimental acute alcohol pancreatitis-related liver damage and endotoxemia: synbiotics but not metronidazole have a protective effect / F. Marotta, R. Barreto , C.C. Wu // Chin J. Dig Dis. – 2005. – Vol. 6 № 4. – P. 193–197.
Misra, A. Clinical features of metabolic derangements in aquired generalized lipodystrophy: case report and review of the literature / A. Misra, A. Carg // Medicine. – 2003. – Vol. 82. – P. 129–146.
Mucosal cytokine production in small-intestinal bacterial overgrowth / S.M. Riordan [et al.] // Scand J. Gastroenterol. – 1996. – Vol. 31, № 10. – P. 977-984.
Nagata, K. Conmmon pathogenic mechanism in development progression of liver injury caused by non-alcoholic and alcoholic steatohepatitis / K. Nagata, H. Suzuki, S. Sakaguchi // J. Toxicol Sci. – 2007. – Vol. 32. – P. 453–468.
Nair, S. Obesity and female gender increase breath ethanol concentration: potential implications for the pathogenesis of nonalcoholic steatohepatitis / S. Nair // Am J. Gastroenterol. – 2001. – Vol. 96, № 4. – P. 1200–1204.
Nordmann, R. Implication of free radical mechanisms in ethanol-induced cellular injury / R. Nordmann, C. Ribiere, H. Rouach // Free Rad Biol Med. – 1992. – Vol. 12. – P. 219–240.
Parola, M. 4-Hydroxy-2,3-alkenals as molecular mediators of oxidative stress in the pathogenesis of liver fibrosis / M. Parola, G. Robino, M.U. Dianzani // Int J. Mol Med. – 1999. – Vol. 4. – P. 425–432.
Pessayre, D. Non-alcoholic steatosis and steatohepatitis: V. Mitochondrial dysfunction and steatohepatitis / D. Pessayre, A. Mansouri, B. Fromently // Am J. Physiol. – 2002. – Vol. 282. – P. 193–199.
Plasma endotoxin and serum cytokine levels in patients with alcoholic hepatitis: relation to severity of liver disturbance / M. Fujimoto [et al.] // Alcohol Clin Exp Res. – 2000. – Vol. 24, № 4. – P. 48–54.
Polymyxin B reduces total parenteral nutrition-associated hepatic steatosis by its antibacterial activity and by blocking deleterious effects of lipopolysaccharide / I. Pappo [et al.] // J. Parenter Enteral Nutr. – 1992. – Vol. 16, № 6. – P. 529–532.
Prevalence of and risk factors for hepatic steatosis in Northern Italy/ S. Bellentani [ et al.] // Ann Intern Med. – 2000. – Vol.132, № 2. – P. 112–117.
Prevention of ethanol-induced liver injury in rats by an agonist of peroxisome proliferator-activated receptor-gamma, pioglitazone / N. Enomoto [et al.] // J. Pharmacol Exp Ther. – 2003. – Vol. 306, № 3. – P. 846–854.
Probiotics and antibodies to TNF inhibit inflammatory activity and improve nonalcoholic fatty liver disease / Z. Li [et al.] // Hepatology. – 2003. – Vol. 37, № 2. – P. 343–350.
Rinella, M.E. The methionine-choline deficient dietary model of steatohepatitis does not exhibit insulin resistance / M.E. Rinella, R.M.Green // J. Hepatol. – 2004. – Vol. 40, № 1. – P. 47–51.
Risk factors of fibrosis in alcohol-induced liver disease / B. Raynard [et al.] // Hepatology. – 2002. – Vol.35, № 3. – P. 635–638.
Role of cytochrome P4502E1-dependent formation of hydroxyethyl free radical in the development of liver damage in rats intragastrically fed with ethanol / E. Albano [et al.] // Hepatology. – 1996. – Vol. 23. – P. 155-163.
Role of oxidative stress, endoplasmic reticulum stress, and c-Jun N-terminal kinase in pancreatic beta-cell dysfunction and insulin resistance / H. Kaneto [et al.] // Int J. Biochem Cell Biol. – 2006. – Vol. 38, № 5/6. – P. 782–793.
The fat-derived hormone adiponectin alleviates alcoholic and non-alcoholic fatty liver diseases in mice / A. Xu [et al.] // J. Clin Invest. – 2003. – Vol. 112. – P. 91–100.
The role of Kupfer cells in alcoholic liver disease / C. M. Oneta [et al.] // In. Alcohol in health and disease. – 2001. – N-Y. – P. 407–426.
The role of small intestinal bacterial overgrowth, intestinal permeability, endotoxaemia, and tumour necrosis factor alpha in the pathogenesis of non-alcoholic steatohepatitis / A.J. Wigg [et al.] // Gut. – 2001. – Vol.48, №2. – P. 206–211.
Tilg, H. Cytokines in alcoholic and nonalcoholic steatohepatitis / H. Tilg, A.M. Diehl // N Engl J. Med. – 2000. – Vol. 343. – P. 1467–1476.
Wakabayashi, I. Relation of drinking alcohol to atherosclerotic risk in type 2 diabetes / I. Wakabayashi, R. Kobaba-Wakabayashi, H. Masuda // Diabetes Care. – 2002. – Vol.25, № 7. – P. 1223–1228.
