ПРОГНОСТИЧЕСКОЕ ЗНАЧЕНИЕ УРОВНЯ ЭКСПРЕССИИ β-КАТЕНИНА ПРИ РАКЕ ЯИЧНИКОВ
Аннотация
В 65 случаях первичного рака яичников иммуногистохимическим методом изучена экспрессия β-катенина. Выявлена зависимость уровня экспрессии от степени дифференцировки, стадии FIGO, наличия метастазов и пятилетней выживаемости.
Литература
Введение в молекулярную биологию канцерогенеза: учеб. пособие / А.А. Новик [и др.]; под ред. Ю. Л. Шевченко. - М.: ГЭОТАР-МЕД, 2004. - 224 с.
B-catenin expression, DNA ploidy and clinicopathological features in ovarian cancer: a study in 253 patients / W. Kildal [et al.] // European journal of cancer. - 2005. - Vol. 41. - P. 1127-1134.
B-Catenin expression pattern in stage I and II ovarian сarcinomas relationship with β-catenin gene мutations, clinicopathological features, and clinical outcome / C. Gamallo. [et al.] // American Journal of Pathology. - 1999. - Vol. 155. - P. 527-536.
Beta-catenin nuclear localization is associated with grade in ovarian serous carcinoma / C.M. Lee [et al.] // Gynecol. Oncol. - 2003. - Vol. 88. - P. 363-368.
Elevated expression of E-cadherin and alpha-, beta-, and gamma-catenins in metastatic lesions compared with primary epithelial ovarian carcinomas / T. Imai [et al.] // Hum. Pathol. - 2004. -Vol. 35. - P. 1469-1476.
Expression of E-cadherin and beta-catenin in primary and peritoneal metastatic ovarian carcinoma / T. Fujioka [et al.] // Oncol. Rep. - 2001. - Vol. 8. - P. 249-255.
Faleiro-Rodrigues, C. Title-loss of β-catenin is an independent prognostic factor in ovarian carcinomas: а multivariate analysis / C. Faleiro-Rodrigues, I. Macedo-Pinto, D. Pereira // Gene Ther. and Mol. Biol.- 2006. - Vol. 10. - P. 179-184.
Hirohashi, S. Cell adhesion system and human cancer morphogenesis / S. Hirohashi, Y. Kanai // Cancer Sci. - 2003. - Vol. 94. - P. 575-581.
Immunoexpression of Beta-catenin-E-cadherin complex in primary serous ovarian tumors / P. Stawerski [et al.] // Pol. J. Pathol. - 2008. - Vol. 59. - P. 27-32.
Immunohistochemical patterns for alpha- and beta-catenin, E- and N-cadherin expression in ovarian epithelial tumors / F.R Marques [et al.] // Gynecol. Oncol. - 2004. -Vol. 94. - P. 16-24.
Mareel, M. Clinical, сellular, and мolecular аspects of сancer invasion / M. Mareel, A. Leroy // Physiol. Rev. - 2003. - Vol. 83. - P. 337-376.
Mutational analysis of the APC/beta-catenin/Tcf pathway in colorectal cancer / A.B. Sparks [et al.] // Cancer Res. -1998. - Vol. 58. - P. 1130-1134.
Paul, S. Wnt signaling and cancer development: therapeutic implication / S. Paul, A. Dey // Neoplasma. - 2008. - Vol. 55. - P. 165-176.
Prognostic significance of E-cadherin-catenin complex in epithelial ovaian cancer / K.A. Voutilainen [et al.] // J. Clin. Pathol. - 2006. - Vol. 59. - P. 460-467.
Wnt4 inhibits β-catenin/TCF signalling by redirecting β-catenin to the cell membrane / P. Bernard [et al.] // Biol. Cell. - 2008. - Vol. 100. - P. 167-177.
Xiao, L. Expression of beta-catenin and APC protein in ovarian epithelial tumor and its implication / L. Xiao, Li Yu, Mi Can // Chin. J. of Canc. Res. - 2007. - Vol. 19. - P. 72-75.
Xu, W. Mechanistic insights from structural studies of β-catenin and its binding partners / W. Xu, D. Kimelman // Journal of Cell Science. - 2007. - Vol. 120. - P. 3337-3344.
