БИОЛОГИЧЕСКАЯ АКТИВНОСТЬ КУРКУМИНА И ПЕРСПЕКТИВЫ ЕГО ФАРМАКОЛОГИЧЕСКОГО ИСПОЛЬЗОВАНИЯ
Аннотация
Куркумин, полифенольный пигмент из корневища Curcuma longa, обладающий антиоксидантными свойствами, эффективно воздействует на разные внутриклеточные сигнальные пути, оказывая противовоспалительное, иммуномодулирующее, противораковое, нейропротекторное, гепатопротекторное и противовирусное действие. Его эффективность и безопасность у онкологических пациентов отдельно или в сочетании с другими противораковыми препаратами доказана в нескольких клинических исследованиях. Однако лечебное применение куркумина и его аналогов ограничено химической нестабильностью и низкой пероральной биодоступностью, что определяет актуальность использования нанотехнологий для получения новых лекарственных форм куркумина.
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