МОДЕЛИРОВАНИЕ СИНДРОМА ПАРКИНСОНИЗМА У КРЫС ВВЕДЕНИЕМ ЛИПОПОЛИСАХАРИДА



DOI: http://dx.doi.org/10.25298/2221-8785-2018-16-6-690-696


А. В. Бойко (A. V. Boika), Ж. А. Гладкова (Zh. A. Hladkova), Т. Е. Кузнецова (T. Ye. Kuznetsova), В. В. Пономарев (V. V. Ponomarev)

Аннотация


Введение. Нейровоспаление, возможно, участвует в развитии нейродегенерации при болезни Паркинсона (БП).
Цель работы. Изучить возможность получения морфологически подтвержденной модели синдрома паркинсонизма у крыс через 30 суток интраназального (и/н) введения липополисахарида (ЛПС) Escherichia coli.
Материал и методы. Опыты проведены на крысах-самцах линии Wistar. Ежедневно 30 дней и/н основной группе животных (n=7) вводили ЛПС в концентрации 1 мкг/мл, а контрольной группе (n=7) – воду для инъ-
екций. Через 30 суток после начала эксперимента осуществляли забор головного мозга на морфологическое исследование.
Результаты. Различий в моторной активности у крыс основной и контрольных групп не выявлено. Обнаружены выраженные нейродегенеративные и воспалительные изменения черной субстанции, распространяющиеся на область стриатума.
Выводы. Получена нейровоспалительная модель домоторной стадии синдрома паркинсонизма.


Ключевые слова


нейровоспаление; нейродегенерация; болезнь Паркинсона; липополисахарид

Полный текст:

Литература


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