МОДЕЛИРОВАНИЕ СИНДРОМА ПАРКИНСОНИЗМА У КРЫС ВВЕДЕНИЕМ ЛИПОПОЛИСАХАРИДА
Аннотация
Введение. Нейровоспаление, возможно, участвует в развитии нейродегенерации при болезни Паркинсона (БП).
Цель работы. Изучить возможность получения морфологически подтвержденной модели синдрома паркинсонизма у крыс через 30 суток интраназального (и/н) введения липополисахарида (ЛПС) Escherichia coli.
Материал и методы. Опыты проведены на крысах-самцах линии Wistar. Ежедневно 30 дней и/н основной группе животных (n=7) вводили ЛПС в концентрации 1 мкг/мл, а контрольной группе (n=7) – воду для инъ-
екций. Через 30 суток после начала эксперимента осуществляли забор головного мозга на морфологическое исследование.
Результаты. Различий в моторной активности у крыс основной и контрольных групп не выявлено. Обнаружены выраженные нейродегенеративные и воспалительные изменения черной субстанции, распространяющиеся на область стриатума.
Выводы. Получена нейровоспалительная модель домоторной стадии синдрома паркинсонизма.
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