ACINETOBACTER BAUMANNII: РАСПРОСТРАНЕННОСТЬ, СПЕКТР И ДИНАМИКА АНТИБИОТИКОРЕЗИСТЕНТНОСТИ, ЧУВСТВИТЕЛЬНОСТЬ К КОМБИНАЦИЯМ АНТИБИОТИКОВ
Аннотация
Цель. Изучить спектр и динамику антибиотикорезистентности Acinetobacter baumannii, оценить механизмы устойчивости к карбапенемам и чувствительность к комбинациям антибиотиков.
Материал и методы. Для 305 клинических изолятов A.baumannii определена чувствительность к антибиотикам автоматизированным методом. Детекция генов карбапенемаз выполнена методом ПЦР в реальном времени. Чувствительность к комбинациям антибиотиков определена методом тестирования бактерицидности разных комбинаций.
Выводы. Показано увеличение доли A.baumannii в этиологической структуре инфекционной патологии. Отмечено увеличение антибиотикорезистентности. Выявлено наличие генов карбапенемаз ОХА-40. Не обнаружено изолятов, устойчивых к колистину. Комбинации меропенем-колистин, амикацин-колистин, левофлоксацин-колистин проявляли бактерицидную активность в отношении 100% изолятов.
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