ACINETOBACTER BAUMANNII: РАСПРОСТРАНЕННОСТЬ, СПЕКТР И ДИНАМИКА АНТИБИОТИКОРЕЗИСТЕНТНОСТИ, ЧУВСТВИТЕЛЬНОСТЬ К КОМБИНАЦИЯМ АНТИБИОТИКОВ



DOI: http://dx.doi.org/10.25298/2221-8785-2018-16-3-286-291


Д. В. Тапальский (D. V. Tapalsk), Н. А. Бонда (N. A. Bonda)

Аннотация


Цель. Изучить спектр и динамику антибиотикорезистентности Acinetobacter baumannii, оценить механизмы устойчивости к карбапенемам и чувствительность к комбинациям антибиотиков.
Материал и методы. Для 305 клинических изолятов A.baumannii определена чувствительность к антибиотикам автоматизированным методом. Детекция генов карбапенемаз выполнена методом ПЦР в реальном времени. Чувствительность к комбинациям антибиотиков определена методом тестирования бактерицидности разных комбинаций.
Выводы. Показано увеличение доли A.baumannii в этиологической структуре инфекционной патологии. Отмечено увеличение антибиотикорезистентности. Выявлено наличие генов карбапенемаз ОХА-40. Не обнаружено изолятов, устойчивых к колистину. Комбинации меропенем-колистин, амикацин-колистин, левофлоксацин-колистин проявляли бактерицидную активность в отношении 100% изолятов.


Ключевые слова


Acinetobacter baumannii; антибиотикорезистентность; меропенем; колистин; сульбактам; карбапенемазы; комбинации антибиотиков

Полный текст:

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