ПОЛИМОРФИЗМ ГЕНА ЭНДОТЕЛИАЛЬНОЙ СИНТАЗЫ МОНООКСИДА АЗОТА. ЧАСТЬ 2. ПОЛИМОРФНЫЕ ВАРИАНТЫ T786C, 4A/B

  • В. В. Зинчук УО "Гродненский государственный медицинский университет"
  • Д. Д. Жадько УО "Гродненский государственный медицинский университет"
Ключевые слова: эндотелиальная синтаза монооксида азота, генетический полиморфизм

Аннотация

Введение. Полиморфизм T786C, а также полиморфизм переменного числа тандемных повторов в 4-м интроне (4a/b) гена эндотелиальной синтазы монооксида азота имеют важное значение в процессах образования NO в организме.
Цель. Провести анализ литературы и собственных данных по распределению частот аллелей и генотипов, а также физиологических и патогенетических особенностей олиморфизмов Т786С и 4a/b.
Материал и методы. Для проведения анализа литературы была отобрана 41 научная публикация (2 отечественных и 39 зарубежных) за период с 2009 по 2016 гг.
Результаты. Полиморфные варианты Т786С и 4a/b гена эндотелиальной синтазы монооксида связаны с развитием ряда патологий и проявлением физиологических функций в организме.
Выводы. Определенное распределение частот аллелей и генотипов полиморфизмов T786C и 4a/b лежит в основе развития ряда заболеваний. Изучение особенностей полиморфных вариантов T786C и 4a/b важно для понимания механизмов, формирующих кислородный гомеостаз в организме.

Литература

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Song P, Zou S, Chen T, Chen J, Wang Y, Yang J, Song Z, Jiang H, Shi H, Huang Y, Li Z, Shi Y, Hu H. Endothelial nitric oxide synthase (eNOS) T-786C, 4a4b, and G894T polymorphisms and male infertility: study for idiopathic asthenozoospermia and meta-analysis. Biol. Reprod. 2015;92(2):38-46. doi: 10.1095/biolreprod.114.123240.

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Safarinejad MR, Khoshdel A, Shekarchi B, Taghva A, Safarinejad S. Association of the T-786C, G894T and 4a/4b polymorphisms of the endothelial nitric oxide synthase gene with vasculogenic erectile dysfunction in Iranian subjects. BJU Int. 2011;107(12):1994-2001.

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Опубликован
2017-09-07
Как цитировать
1.
Зинчук ВВ, Жадько ДД. ПОЛИМОРФИЗМ ГЕНА ЭНДОТЕЛИАЛЬНОЙ СИНТАЗЫ МОНООКСИДА АЗОТА. ЧАСТЬ 2. ПОЛИМОРФНЫЕ ВАРИАНТЫ T786C, 4A/B. Журнал ГрГМУ (Journal GrSMU) [Интернет]. 7 сентябрь 2017 г. [цитируется по 28 март 2024 г.];15(3):267-74. доступно на: http://journal-grsmu.by/index.php/ojs/article/view/2122