ХЕМОСЕНСОРЫ НУТРИЕНТОВ В ПИЩЕВАРИТЕЛЬНОМ ТРАКТЕ

  • А. М. Хоха УО "Гродненский государственный медицинский университет"
  • Л. Б. Заводник УО "Гродненский государственный медицинский университет"
Ключевые слова: желудочно-кишечный тракт, энтероэндокринные клетки, рецепторы TAS1R, CaSR, GPRC6A, MGluR, LPA5, FFA1-4, GPR84, GPR119, транслоказы CD36, SGLT1, GLUT2, PepT1

Аннотация

 В статье представлены литературные данные о молекулярных механизмах детекции аминокислот, олиго­пептидов, сладких молекул, жирных кислот и их производных в пищеварительном тракте. Охарактеризован ре­цепторный аппарат энтероэндокринных клеток и основные пути трансдукции сигнала. Продемонстрировано, что важная роль в детекции принадлежит транслоказам нутриентов. На основе хемосенсорной информации энтеро­эндокринные клетки регулируют биосинтез и высвобождение кишечных пептидов – холецистокинина, глюкагоно­подобного пептида, глюкозозависимого инсулинотропного пептида, гастрина, пептида YY. Последние регулируют секреторную и двигательную активность желудочно-кишечного тракта, гомеостаз глюкозы, энергетический статус организма и пищевое поведение. Специфические рецепторы и транслоказы нутриентов представляют интерес с точки зрения создания фармакологических препаратов, предназначенных для лечения заболеваний пище­варительного тракта, метаболических нарушений, в том числе ожирения и диабета 2-го типа.

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Опубликован
2016-10-14
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Хоха АМ, Заводник ЛБ. ХЕМОСЕНСОРЫ НУТРИЕНТОВ В ПИЩЕВАРИТЕЛЬНОМ ТРАКТЕ. Журнал ГрГМУ (Journal GrSMU) [Интернет]. 14 октябрь 2016 г. [цитируется по 20 апрель 2024 г.];(3(55):24-9. доступно на: http://journal-grsmu.by/index.php/ojs/article/view/1970