УСТОЙЧИВОСТЬ К НАРКОТИЧЕСКОМУ ДЕЙСТВИЮ ЭТАНОЛА И СИНТЕЗ АЦЕТИЛХОЛИНА В СИНАПТОСОМАХ КОРЫ ГОЛОВНОГО МОЗГА КРЫС
Аннотация
Настоящее исследование посвящено изучению состояния синаптосомального биосинтеза ацетилхолина в мозге крыс с различной биологически детерминированной чувствительностью к наркотическому действию этанола
Литература
Алкоголь и углеводы/Островский Ю.М., Сатановская В.И., Островский С.Ю., и др.//Метаболические предпосылки и последствия потребления алкоголя. -Мн.: Наука и техника, 1988. -С. 43-86.
Нейрохимические основы толерантности к этанолу/Чумакова О.В. Сатановская В.И. Ковальчук В.Г. и соавт.//Тез. докл. V Всероссийского съезда невропатологов и психиатров. -Иркутск, 1985. -№4. -С. 144-146.
Островский Ю.М., Сатановская В.И., Садовник М.Н. Биологический компонент в генезе алкоголизма. -Минск, 1986.
Bielarczyk H., Szutowicz A. Evidence for the regulatory function of synaptoplasmic acetyl-CoA in acetylcholine synthesis in nerve endings//Biochem. J. -1989. -Vol. 262. -P. 377-380.
Cholinergic system and memory in the rat: effects of chronic ethanol, embryonic basal forebrain transplants, and excitotoxic lesions of the cholinergic basal forebrain projection system/Arendt T., Allen Y., Marchbanks R.M. at al.//Neuroscience. -1989. -Vol. 33. -P. 435462.
Cain S.T., Routtenberg A. Phosphorylation of pyruvate dehydrogenises in the hippocampal slice: time course of response to cellular depolarization//Neurosc. Let. -1991. -Vol. 130. -P. 65-68.
Carroll P.T. Evidence to suggest that extracellular acetate is accumulated by rat hippocampal cholinergic nerve terminals for acetylcholine formation and release//Brain Res. -1997. -Vol. 753, N 1. -P. 47-55.
Degeneration of rat cholinergic basal forebrain neurons and reactive changes in nerve growth factor expression after chronic neurotoxic injury -I. Degeneration and plastic response of basal forebrain neurons/Arendt T., Bruckner M.K., Pagliusi S. at al.//Neuroscience. -1995. -Vol. 65, N 3. -P. 633-645.
Dolezal V, Tucek S Utilization of citrate, acetylcarnitine, acetate, pyruvate and glucose for the synthesis of acetylcholine in rat brain slices//J. Neurochem. -1981. -Vol. 4. -P. 1323-1330.
Fadda F., Rossetti Z.L. Chronic ethanol consumption: from neuroadaptation to neurodegeneration//Prog. Neurobiol. -1998. -Vol. 56, N 4. -P. 385 -431.
Folders M., Barrit J.B. Regulation by calcium ions of pyruvate carboxilation, pyruvate transport and adenine nucleotide transport in isolated rat liver mitochondria//J. Biol. Chem. -1977. -Vol. 15. -P. 5372-5380.
Ho A.K.S., Kissin B. Evidence of a control cholinergic role in alcohol preference // In: Alcohol intoxication and Withdrawal // New York- London: Plenum Press. - 1975. - P. 303 - 310
Jope R., Blass J.P. A comparison of the pyruvate dehydrogenises in mitochondria from rat brain and liver//Biochem. J. -1975. -Vol. 150 -P. 397-403.
Lai J.C.K., DiLorenzo J. C., Sheu K.F.R. Pyruvate dehydrogenises complex is inhibited in calcium loaded cerebrocortical mitochondria//Neurochem. Res. -1988. -Vol. 13. -P. 1043-1048.
Lynch M., Littleton J.M. Possible association of alcohol tolerance with increase synaptic Ca+2 sensitivity//Nature. -1983. -Vol. 303. -P. 175-177.
Pathways of beta-hydroxybutyrate contribution to metabolism of acetyl-CoA and acetylcholine in rat brain nerve terminals/Tomaszewicz M., Bielarczyk H., Jankowska A., Szutowicz A.//Folia Neuropathol. -1997. -Vol. 35. -P. 244-246.
Responses to cholinergic agonists of rats selectively bred for differential sensitivity to ethanol/Fiebre C.M., Romm E., Collins J.T. at al.//Alcoholism Clin. and Exp. Res. -1991. -Vol. 35, N 2 -P. 270 -276, 12.
Szutowicz A., Tomaszewicz M., Bielarczyk H. Disturbances of acetyl-CoA, energy and acetylcholine metabolism in some encephalopathies//Acta Neurobiol. Exp. -1996. -Vol. 56, N 1. -P. 323 -339
Szutowicz A., Lysiak W. Regional and subcellular distribution of ATP-citratlyase and other enzymes of acetyl-CoA metabolism in rat brain//J. Neurochem. -1980. -Vol. 35. -P. 775-785.
Szutowicz A., Stepien M., Piec G. Determination of pyruvate dehydrogenase and acetyl-CoA synthetase activities using citratsynthetase//Analyt. Biochem. -1981. -Vol. 115. -P. 81 -87.
Szutowicz A., Bielarczyk H., Elimination of CoASH interferences from acetyl-CoA cycling assay by maleic anhydride//Analyt. Biochem. -1987. -Vol. 164. -P. 292 -296.
Szutowicz A, Tomaszewicz M, Bielarczyk H. Key role of acetyl-CoA in cytoplasm of nerve terminals in disturbances of acetylcholine metabolism in brain//Folia Neuropathol. -1997. -Vol. 4. -P. 241243.
Tabakoff B. Melhior C. Hoffman P. Commentary on ethanol tolerance//Alcoholism: Clin. and Exp. Res. -1982. -V. 6, № 2. -Р 583-587.
Tabakoff B., Hoffman P.L. Tolerance and the etiology of alcoholism: Hypothesis and mechanism//Alcoholism: Clinical and Experimental Research. -1988. -Vol. 12, N 1.-P. 184 -186.
