КСЕНОГЕННАЯ КЛЕТОЧНАЯ ТЕРАПИЯ: СОВРЕМЕННОЕ СОСТОЯНИЕ ПРОБЛЕМЫ И ПЕРСПЕКТИВЫ СВИНОЙ КЛЕТОЧНОЙ ТРАНСПЛАНТАЦИИ

  • В. Я. Хрыщанович УО «Белорусский государственный медицинский университет»
  • С. И. Третьяк УО «Белорусский государственный медицинский университет»
  • А. А. Глинник УО «Белорусский государственный медицинский университет»
Ключевые слова: клеточная терапия, клеточные трансплантаты, болезни человека

Аннотация

Большинство различных типов клеток, представленных в зрелых и еще созревающих тканях, обладают уни­кальными физиологическими особенностями. Клеточная терапия является новой технологией, позволяющей ис­пользовать столь широкое разнообразие клеток в лечении целого ряда патологических состояний человека. Тяжелые заболевания и травмы сопровождаются гибелью клеток или клеточной дисфункцией. Клеточная транс­плантация позволяет заменить поврежденную или утраченную ткань, восстанавливая, таким образом, ее пре­жнюю функциональную активность. Ограниченное применение клеточных трансплантатов, как основных компо­нентов описываемой технологии, в определенной степени обусловлено нехваткой пригодных для транспланта­ции клеток человека. Указанное обстоятельство значительно затормозило дальнейшее развитие клеточной транс­плантологии. Соответственно, в настоящее время традиционным и, пожалуй, единственным примером клеточ­ной терапии в рутинной клинической практике является переливание крови и ее клеточных компонентов. Не­смотря на многочисленные попытки наращивания человеческой клеточной биомассы в культуре ткани, суще­ствующие технологические трудности в отношении пролиферативной способности и сохранения клетками оп­ределенного фенотипа ограничили их применение для трансплантации. Использование с этой целью человечес­ких стволовых клеток с последующей их дифференцировкой является перспективным направлением и обладает большим потенциалом, однако основное препятствие связано с получением достаточного количества таких мультипотентных клеток. Таким образом, в настоящее время приоритетным источником донорского материа­ла для трансплантации являются нативные клетки. В настоящем обзоре изучены возможности и перспективы применения в клинической практике тканей свиньи, как потенциального источника разнообразных нативных клеток, для лечения заболеваний человека. Кроме того, нами проанализированы преимущества и недостатки ксеногенной клеточной терапии.

Литература

Gibson, T. Zoografting - A curious chapter in the history of plastic surgery / T. Gibson // Br. J. of Plast. Surg. - 1955. - Vol. 8. - P. 234-242.

Transplantation of porcine fetal pancreas to diabetic patients / C.G. Groth [et al.] // Lancet. - 1994. - Vol. 344. - P. 1402-1404.

Mixed xenogeneic chimerism (mouse + rat to mouse) to induce donor-specific tolerance to sequential or simultaneous islet xenografts / H. Li [et al.] // Transplantation. - 1994. - Vol. 57. - P. 592-598.

Long-term normalization of diabetes mellitus after xenotransplantation of fetal pancreatic islet cells into the blood stream without immunosuppressive therapy / A.V. Prochorov [et al.] // Transplantation Proceedings. - 2004. - Vol. 36. - P. 2855-2856.

Ксенотрансплантация тканей в сосудистое русло / А.В. Шотт [и соавт.] // Здравоохранение Белоруссии. - 1989. - № 11. - С. 28-32.

Fishman, J. Miniature swine as organ donors for man: Strategies for prevention of xenotransplant-associated infections / J. Fishman // Xenotransplantation. - 1994. - Vol. 1. - P. 47-57.

Fine, A. Human fetal tissue research: Practice, prospects, policy / A. Fine // Cell Transplant. - 1994. - Vol. 3. - P. 113-145.

Lindvall, O. Update in fetal transplantation: The Swedish experience / O. Lindvall // Move. Disord. - 1998. - Vol. 13 (Suppl. 1). - P. 8 3-8 7.

Autotransplantation of dispersed pancreatic islet tissue combined with total or near-total pancreatectomy for treatment of chronic pancreatitis / A.C. Farney [et al.] // Surgery. - 1991. - Vol. 110. - P. 427-439.

. T h e i m m u n o l o g i c a l l y p r i v ileged site for i sl et cel l transplantation / M. Gotoh [et al.] // Transplant. Proc. - 1989. - Vol. 21. - P. 2691-2692.

Allotransplantation of rat islets into the cisterna magna of streptozotocin-induced diabetic rats / H.C. Lee [et al.] // Transplantation. - 1992. - Vol. 53. - P. 513-516.

McEvoy, R.C., Leung, P.E. Transplantation of fetal rat islets into the cerebral ventricles of alloxan-diabetic rats. Amelioration of diabetes by syngeneic but not allogeneic islets / R.C. McEvoy, P.E. Leung // Diabetes. - 1983. - Vol. 32. - P. 852-857.

Intrauterine transplantation of isogenic pancreatic islets in experimental diabetic rats / I. Sakonju // J. Vet. Med. Sci. - 1994. - Vol. 56. - P. 729-733.

Selawry, H.P., Whittington, K.B., Forster, H.G. Intratesticular islet xenograft survival in relation to tissue cyclosporine levels / H.P. Selawry, K.B. Whittington, H.G. Forster // Am. J. Med. Sci. - 1988. - Vol. 295. - P. 497-502.

Faustman, D., Coe, C. Prevention of xenograft rejection by masking donor HLA class I antigens / D. Faustman, C. Coe // Science. - 1991. - Vol. 252. - P. 1700.

P.; Marlier, L.; Privat, A.; Mallet, J. Behavioral effect of engineered cells that synthesize L-DOPA or dopamine after grafting into the rat neostriatum / P. Horellou [et al.] // Eur. J. Neurosci. - 1990. - Vol. 2. - P. 116-119.

Lafferty, K.J., Prowse, S.J., Simeonovic, C.J. Immunobiology of tissue transplantation: A return to the passenger leukocyte concept / K.J. Lafferty, S.J. Prowse, C.J. Simeonovic // Annu. Rev. Immunol. - 1993. - Vol. 1. - P. 143-173.

The effect of islet cell culture in vitro at 24°C on graft survival and MHC antigen expression / J.F. Markmann [et al.] // Transplantation. - 1990. - Vol. 49. - P. 272-277.

Grafting fibroblasts genetically modified to produce L-dopa in a rat model of Parkinson disease / J.A. Wolff [et al.] // Proc. Natl. Acad. Sci. USA. - 1989. - Vol. 86. - P. 9011-9014.

Korbutt, G.S., Elliott, J.F., Rajotte, R.V. Cotransplantation of allogeneic islets with allogeneic testicular cell aggregates allows long- term graft survival without systemic immunosuppression / G.S. Korbutt, J.F. Elliott, R.V. Rajotte // Diabetes. - 1997. - Vol. 46. - P. 317-322.

. Prevention of islet allograft rejection with engineered myoblasts expressing FasL in mice / H.T. Lau [et al.] // Science. - 1996. - Vol. 273. - P. 109-112.

Selawry, H.P., Cameron, D.F. Sertoli cell-enriched fractions in successful islet cell transplantation / H.P. Selawry, D.F. Cameron / / Cell Transplant. - 1993. - Vol. 2. - P. 123-129.

Histological evidence of fetal pig neural cell survival after transplantation into a patient with Parkinson's disease / T. Deacon [et al.] // Nat. Med. - 1997. - Vol. 3. - P. 350-353.

Xenotransplantation of porcine fetal ventral mesencephalon in a rat model of Parkinson's disease: Functional recovery and graft morphology / W.R. Galpern [et al.] // Exp. Neurol. - 1996. - Vol. 140. - P. 1-13.

Intrastriatal transplantation of cross-species fetal striatal cells reduces abnormal movements in a primate model of Huntington's disease / P. Hantraye [et al.] // Proc. Natl. Acad. Sci. USA. - 1982. - Vol. 89. - P. 4187-4191.

Transplanted xenogeneic neural cells in neurodegenerative disease models exhibit remarkable axonal target specificity and distinct growth patterns of glial axonal fibers / O. Isacson [et al.] // Nat. Med. - 1995. - Vol. 1. - P. 1189-1194.

Bengzon, J., Kokaia, Z., Lindvall, O. Specific functions of grafted locus coeruleus neurons in the kindling model of epilepsy / J. Bengzon, Z. Kokaia, O. Lindvall // Exp. Neurol. - 1993. - Vol. 122. - P. 143-154.

Bengzon, J., Lindvall, O. Transplantation in experimental epilepsy. Lindvall, O., ed. In: Basic and clinical aspects of neuroscience: Restoration of brain function by tissue transplantation / J. Bengzon, O. Lindvall // Berlin: Springer Verlag. - 1993. - P. 39-50.

Bjorklund, A. Neural transplantation - An experimental tool with clinical possibilities / A. Bjorklund // Trends Neurosci. - 1991. - Vol. 14. - P. 319-322.

Fine, A., Meldrum, B.S., Patel, S. Modulation of experimentally induced epilepsy by intracerebral grafts of fetal GABAergic neurons / A. Fine, B.S. Meldrum, S. Patel // Neuropsychology. - 1990. - Vol. 28. - P. 627-634.

Neuropathological evidence of graft survival and striatal reinnervation after the transplantation of fetal mesencephalic tissue in a patient with Parkinson's disease [see comments] / J.H. Kordower [et al.] // N. Engl. J. Med. - 1995. - Vol. 332. - P. 1118-1124.

Olanow, C.W., Kordower, J.H., Freeman, T.B. Fetal nigral transplantation as a therapy for Parkinson's disease / C.W. Olanow, J.H. Kordower, T.B. Freeman // Trends Neursci. - 1996. - Vol. 19. - P. 1 02-1 09.

Deacon, T.W., Pakzaban, P., Isacson, O. The lateral ganglionic eminence is the origin of cells committed to striatal phenotypes: Neural transplantation and developmental evidence / T.W. Deacon, P. Pakzaban, O. Isacson // Brain Res. - 1994. - Vol. 668. - P. 211­21 9.

Dunnett, S.B. Functional repair of striatal systems by neural transplants: Evidence for circuit reconstruction / S.B. Dunnett // Behav. Brain Res. - 1995. - Vol. 66. - P. 133-142.

A novel mode of immunoprotection of neural xenotransplants: Masking of donor major histocompatibility complex class I enhances transplant survival in the central nervous system / P. Pakzaban [et al.] // Neuroscience. - 1995. - Vol. 65. - P. 983-996.

Bunge, M. B. Transplantation of purified populations of Schwann cells into lesioned adult rat spinal cord / M.B. Bunge // J. Neurol. - 1994. - Vol. 242(Suppl. 1). - P. 36-S39.

Wu, Z.G., Shi, Z.Q., Lu, Z. In vitro culture and transplantation of encapsulated human fetal islets as an artificial endocrine pancreas / Z.G. Wu, Z.Q. Shi, Z. Lu // ASAIO Trans. - 1989. - Vol. 35. - P. 736-738.

A study of cadaveric fetal adrenal used for adrenal transplantation to treat Addison's disease. Thirteen cases reported / Z.B. Yan [et al.] // Transplant. Proc. - 1990. - Vol. 22. - P. 280-282.

Mito, M., Kusano, M. Hepatocyte transplantation in man / M. Mito, M. Kusano // Cell Transplant. - 1993. - Vol. 2. - P. 65-74.

Hepatocyte transplantation as a bridge to orthotopic liver transplantation in terminal liver failure / S.C. Storm [et al.] // Transplantation. - 1997. - Vol. 63. - P. 559-569.

Percutaneous hepatocyte transplantation (PHT) in liver failure / B.M. Bilir [et al.] // Hepatology. - 1997. - Vol. 26. - P. 252A.

Treatment of the Crigler-Najjar syndrome Type I with hepatocyte transplantation / I.J. Fox [et al.] // N. Engl. J. Med. - 1998. - Vol. 338. - P. 1422-1426.

Transplantation of fetal retinal pigment epithelium in age- related macular degeneration with subfoveal neovascularization / P.V. Algvere [et al.] // Graefe's Arch. Clin. Exp. Ophthalmol. - 1994. - Vol. 232. - P. 707-716.

Rando, T.A., Pavlath, G.K., Blau, H.M. The fate of myoblasts following transplantation into muscle / T.A. Rando, G.K. Pavlath, H.M. Blau // Exp. Cell Res. - 1995. - Vol. 220. - P. 383-389.

Pigment cell transplantation for the treatment of vitiligo: A progress report / W. Lontz [et al.] // J. Am. Acad. Derm. - 1994. - Vol. 3. - P. 591-597.

Paddle-Ledinek, J.E., Cruiskshank, D.G., Masterton, J.P. Skin replacement by cultured keratinocyte grafts: An Australian experience / J.E. Paddle-Ledinek, D.G. Cruiskshank, J.P. Masterton // Burns. - 1997. - Vol. 23. - P. 204-211.

Minas, T., Nehrer, S. Current concepts in the treatment of articular cartilage defects / T. Minas, S. Nehrer // Orthopedics. - 1997. - Vol. 20. - P. 525-538.

Somatic cell cloned transgenic bovine neurons for transplantation in parkinsonian rats / W.M. Zawada [et al.] // Nat. Med. - 1998. - Vol. 4. - P. 569-574.

Fine, A., Ault, B., Rapoport, S.I. Mouse trisomy 16 neurons, a model of human trisomy 21 (Down syndrome), can be maintained by intracerebral transplantation / A. Fine, B. Ault, S.I. Rapoport // Neurosci. Lett. - 1991. - Vol. 122. - P. 4-8.

Nogradi, A., Vrobova, G. Improved motor function of denervated rat hindlimb muscles induced by embryonic spinal cord grafts / A. Nogradi, G. Vrobova // Eur. J. Neurosci. - 1996. - Vol. 8. - P. 2198-2203.

Transplantation of fetal neocortex ameliorates sensorimotor and locomotor deficits following neonatal ischemic-hypoxic brain

injury in rats / E.M. Jansen [et al.] // Exp. Neurol. - 1997. - Vol. 147. - P. 487-497.

Intrathecal delivery of CNTF using encapsulated genetically modified xenogeneic cells in amyotrophic lateral sclerosis patients (published erratum appears in Nat. Med. 2:1041; 1996) / P. Aebischer [et al.] // Nat. Med. - 1996. - Vol. 2. - P. 696-699.

Sotelo, C., Alvarado-Mallart, R.M. Growth and differentiation of cerebellar suspensions transplanted into the adult cerebellum of mice with heredodegenerative ataxia / C. Sotelo, R.M. Alvarado- Mallart // Proc. Natl. Acad. Sci. USA. - 1986. - Vol. 83. - P. 1135­1139.

Triarhou, L. C. The cerebellar model of neural grafting: Structural integration and functional recovery / L.C. Triarhou // Brain Res. Bull. - 1996. - Vol. 39. - P. 127-138.

Jacobs, S.E., Fine, A., Juliano, S.L. Cholinergic basal forebrain transplants restore diminished metabolic activity in the somatosensory cortex of rats with acetylcholine depletion / S.E. Jacobs, A. Fine, S.L. Juliano // J. Neurosci. - 1994. - Vol. 14. - P. 697-711.

Tsue, T.T., Oesterle, E.D., Rubel, E.W. Hair cell regeneration in the inner ear / T.T. Tsue, E.D. Oesterle, E.W. Rubel // Otol. Head Neck Surg. - 1994. - Vol. 111. - P. 281-301.

Eaton, M.J. Lumbar transplants of immortalized serotonergic neurons alleviate chronic neuropathic pain / M.J. Eaton [et al.] // Pain. - 1997. - Vol. 72. - P. 59-69.

Li, Y.J., Low, W.C. Intraretrosplenial cortical grafts of fetal cholinergic neurons and the restoration of spatial memory function / Y.J. Li, W.C. Low // Cell Transplantat. - 1997. - Vol. 6. - P. 85-93.

Estrogen as a growth factor to central nervous cells. Estrogen treatment promotes development of acetylcholinesterase-positive basal forebrain neurons transplanted in the anterior eye chamber / H. Honjo [et al.] // J. Steroid Biochem. Mol. Biol. - 1992. - Vol. 41. - P. 633-635.

Facilitated sexual behavior reversed and serotonin restored by raphe nuclei transplanted into denervated hypothalamus / V.N. Luine [et al.] // Science. - 1984. - Vol. 226. - P. 1436-1439.

Kolarik, J., Nadvornik, P. The first transplantation of emb y o n i c t i ssu e i n t o t h e b r a in in schi zophr eni a / J . Kol a r i k , P. Nadvornik // Cek. Neurol. Neurochir. - 1989. - Vol. 52. - P. 95-97.

Reduction of serum cholesterol inWatanabe rabbits by xenogeneic hepatocellular transplantation / J.R. Gunsalus [et al.] // Nat. Med. - 1997. - Vol. 3. - P. 48-53.

Human liver cell transplantation: Prolonged function in athymic-Gunn and athymic-analbuminemic hybrid rats / A. D. Moscioni [et al.] // Gastroenterology. - 1989. - Vol. 96. - P. 1546­1551.

Di Lorento, D., Del Cerro, C., Del Cerro, M. Cyclosporine treatment promotes survival of human fetal neural retina transplanted to the subretinal space of the light-damaged Fischer 344 rat / D. Di Lorento, C. Del Cerro, M. Del Cerro // Exp. Neurol. - 1996. - Vol. 140. - P. 37-42.

Formation of nascent intercalated disks between grafted and host myocardium / M.H. Soonpaa [et al.] // Science. - 1994. - Vol. 264. - P. 98-101.

Satellite cells transplantation for myocardial repair: Labeling techniques / D. Greentree [et al.] // Transplant. Proc. - 1994. - Vol. 26. - P. 3357.

Mayer, N.J., Rubin, S.A. Molecular and cellular prospects for repair, augmentation, and replacement of the failing heart / N. J. Mayer, S.A. Rubin // Am. Heart J. - 1997. - Vol. 134. - P. 577-586.

Guelinckx, P.J., Sinsel, N.K. Muscle transplantation for reconstruction of a smile after facial paralysis. Past, present, and future / P.J. Guelinckx, N.K. Sinsel // Microsurgery. - 1996. - Vol. 17. - P. 391-401.

Lane, J.M. Osteoporosis. Medical prevention and treatment / J.M. Lane // Spine (Suppl.). - 1997. - Vol. 22. - P. 32S-37S.

Transplantation of immortalized, nontumorigenic parotid acinar cells into the allogenic rat parotid gland and oral suabmucosa / G.E. Krause [et al.] // Proc. Soc. Exp. Bio. Med. - 1996. - Vol. 212. - P. 160-164.

Functional and morphometric study of cryopreserved human parathyroid tissue transplanted into nude mice / Y. Tanaka [et al.] // World J. Surg. - 1996. - Vol. 20. - P. 692-699.

Fetal grafts containing suprchiasmatic nuclei restore the diurnal rhythm of CRH and POMC mRNA in aging rats / A. Cai [et al.] // Am. J. Physiol. - 1997. - Vol. 273. - P. R1764-R1770.

What nature's knockout mice teaches us about GnRH activity: Hypogonadal mice and neuronal mice / M.J. Gibson [et al.] // Horm. Behav. - 1997. - Vol. 31. - P. 212-220.

Enhancement of testosterone secretion by normal adult human leydig cells by co-culture with enriched preparations of normal human sertoli cells / H. Lejeune [et al.] // Int. J. Androl. - 1993. - Vol. 16. - P. 27-34.

Gender-linked brain inj ury in experimental stroke / N. J. Alkayed [et al.] // Stroke. - 1998. - Vol. 29. - P. 159-165.

Woodruff, M.F.A. The transplantation of tissues and organs. Springfield, IL: C.C. Thomas; 1960.

Cell transplantation for central nervous system disorders / T.K. Koutouzis [et al.] // Crit. Rev. Neurobiol. - 1994. - Vol. 8. - P. 125-162.

Production of marked prolongation of islet xenograft survival (rat to mouse) by local release of mouse and rat antilymphocyte sera at transplant site / P. Aebischer [et al.] // Diabetes. - 1991. - Vol. 40. - P. 482-485.

Xenotransplantation of canine, bovine, and porcine islets in diabetic rats without immunosupression / R.P. Lanza [et al.] // Proc. Natl. Acad. Sci. USA. - 1991. - Vol. 88. - P. 11100-11104.

Porcine islets for xenotransplantation / T. Maki [et al.] // Transplantation. - 1996. - Vol. 62. - P. 136-148.

. Treatment of chronic postoperative otorrhea with cultured keratinocytes sheets / T. Somers [et al.] // Ann. Otol. Rhinol. Laryngol. - 1997. - Vol. 106. - P. 15-21.

The fetal fibroblast: The effector cell of scarless fetal skin repair / H.P. Lorenz [et al.] // Plast. Reconstruct. Surg. - 1995. - Vol. 96. - P. 1251-1259.

Formation of hair follicles from a single-cell suspension of embryonic rat skin by a two-step procedure in vitro / S. Ihara [et al.] // J. Clin. Pharmacol. - 1991. - Vol. 36. - P. 1081-1092.

Temporomandibular joint disc replacement made by tissue- engineered growth of cartilage / W.C. Puelacher [et al.] // J. Oral Maxil. Surg. - 1994. - Vol. 52. - P. 1172-1177.

Enterocyte transplantation using cell-polymer devices to create intestinal epithelial-lined tubes / G.M. Organ [et al.] // Transplant. Proc. - 1993. - Vol. 25. - P. 998-1001.

Holland, E.J. Epithelial transplantation for the management of severe ocular surface disease / E.J. Holland // Trans. Am. Ophthalmol. Soc. - 1996. - Vol. 94. - P. 677-743.

Clinch, T.E., Goins, K.M., Cobo, L.M. Treatment of contact lens-related ocular surface disorders with autologous conj unctival transplantation / T.E. Clinch, K.M. Goins, L.M. Cobo // Opthalmology. - 1992. - Vol. 99. - P. 634-638.

Myelination of the canine central nervous system by glial cell transplantation: A model for repair of human myelin disease / D.R. Archer [et al.] // Nat. Med. - 1997. - Vol. 3. - P. 54-59.

Isacson, O., Deacon, T.W. Specific axon guidance factors persist in the adult brain as demonstrated by pig neuroblasts transplanted to the rat / O. Isacson, T.W. Deacon // Neuroscience. - 1996. - Vol. 75. - P. 827-837.

Cross-species intracerebral grafting of embryonic swine dopaminergic neurons / T.B. Freeman [et al.] // Prog. Brain Res. - 1988. - Vol. 78. - P. 473-477.

Xenografting of fetal pig ventral mesencephalon corrects motor asymmetry in the rat model of Parkinson's disease / T.K. Huffaker [et al.] // Exp. Brain Res. - 1989. - Vol. 77. - P. 329-36.

Fetal human and pig mesencephalon xenografts have equal effectiveness in behavioral restoration of damaged rat brain / O. V. Kopyov [et al.] // Transplant. Proc. - 1992. - Vol. 24. - P. 547-548.

Effect of coherent blue light on fetal pig xenotransplants / O.V. Kopyov [et al.] // Transplant. Proc. - 1992. - Vol. 24. - P. 549­550.

Cytoarchitectonic development, axon-glia relationships, and long distance axon growth of porcine striatal xenografts in rats / T.W. Deacon [et al.] // Exp. Neurol. - 1994. - Vol. 130. - P. 151­1 6 7.

Survival of implanted fetal dopamine cells and neurologic improvement 12 to 46 months after transplantation for Parkinson's disease / C.R. Freed [et al.] // N. Engl. J. Med. - 1992. - Vol. 327. - P. 1549-1555.

Bilateral fetal nigral transplantation into the postcommissural putamen in Parkinson's disease / T.B. Freeman [et al.] // Ann. Neurol. - 1995. - Vol. 38. - P. 379-388.

Grafts of fetal dopamine neurons survive and improve motor function in Parkinson's disease / O. Lindvall [et al.] // Science. - 1990. - Vol. 247. - P. 574-577.

Evidence for long-term survival and function of dopaminergic grafts in progressive Parkinson's disease / O. Lindvall [et al.] // Ann. Neurol. - 1994. - Vol. 35. - P. 172-180.

Successful ex vivo gene therapy directed to liver in a patient with familial hypercholesterolemia / M. Grossman [et al.] // Nat. Genet. - 1994. - Vol. 6. - P. 335-341.

Li, L. Optimal conditions for long-term photoreceptor cell rescue in RCS rats: The necessity for healthy RPE transplants / L. Li, J.E. Turner // Exp. Eye Res. 1991. - Vol. 52. - P. 669-679.

Transplantation of pancreatic islets in diabetic nonhuman primates / D. Steele [et al.] // Transplant. Proc. - 1994. - Vol. 26. - P. 3317-3318.

Immune response of diabetic patients against transplanted porcine fetal islet cells / M. Kumagai-Braesch [et al.] // Transplant. Proc. - 1992. - Vol. 24. - P. 679-680.

Kinetics and character of xenoantibody formation in diabetic patients transplanted with fetal porcine islet cell clusters / M. Satake [et al.] // Xenotransplantation. - 1994. - Vol. 1. - P. 24-35.

Хрыщанович, В.Я. Технология макроинкапсуляции при трансплантации тироцитов и паратироцитов без иммуносупрес- сивной терапии / В.Я. Хрыщанович, С.И. Третьяк, А.Н. Харламо­ва // Вести НАН Беларуси (серия медицинских наук). - 2011. - №2. - С. 42-48.

Simeonovic, C.J. Effect of GK1.5 monoclonal antibody dosage on survival of pig proislet xenografts in CD41 T cell-depleted mice / C.J. Simeonovic, C. Rhodri, J.D. Wilson // Transplantation. - 1990. - Vol. 49. - P. 849-856.

Increased anti-Gal activity in diabetic patients transplanted with fetal porcine islet cell clusters / U. Galili [et al.] // Transplantation. - 1995. - Vol. 59. - P. 1549-1556.

Immunological characteristics of islet cell xenotransplantation in humans and rodents / M. Satake [et al.] // Immunol. Rev. - 1994. - Vol. 141. - P. 192-210.

A role for CD95 ligand in preventing graft rejection / D. Bellgrau [et al.] // Nature. - 1995. - Vol. 377. - P. 630-632.

Benson, J.L. Immune privilege in the anterior chamber of the eye: Alloantigens and tumour-specific antigens presented into the anterior chamber simultaneously induce suppression and activation of delayed hypersensitivity to the respective antigens / J.L. Benson, J.Y. Niederkorn // Immunology. - 1992. - Vol. 77. - P. 189-195.

Survival of transplanted porcine neural cells treated with F(ab9)2 antibody fragments directed against donor MHC class-I in a rodent model / J.H. Dinsmore [et al.] // Transplant. Proc. - 1996. - Vol. 28. - P. 817-818.

Barriers to xenotransplantation / F.H. Bach [et al.] // Nat. Med. - 1995. - Vol. 1. - P. 869-873.

Galili, U. Interaction of the natural anti-Gal antibody with alpha-galactosyl epitopes: A major obstacle for xenotransplantation in humans / U. Galili // Immunol. Today. - 1993. - Vol. 14. - P. 480­482.

LaVecchio, I.L. Enzymatic removal of alpha-galactosyl epitopes from porcine endothelial cells diminishes the cytotoxic effect of natural antibodies / I.L. LaVecchio, A.D. Dunne, A.S.B. Edge // Transplantation. - 1995. - Vol. 60. - P. 841-847.

Delayed xenograft rejection / F.H. Bach [et al.] // Immunol. Today. - 1996. - Vol. 17. - P. 379-384.

Protection of pig kidney (PK15) cells from the cytotoxic effect of anti-pig antibodies by ?-galactosyl oligosaccharides / F.A. Neethling [et al.] // Transplantation. - 1994. - Vol. 57. - P. 959­963.

Intact pig pancreatic islet function in the presence of human xenoreactive natural antibody binding and complement activation / V. Mirenda [et al.] // Transplantation. - 1997. - Vol. 63. - P. 1452­1462.

. En zyma ti c re m od e l li n g o f t he car bohydra t e su rfa ce of a xenogenic cell substantially reduces human antibody binding and complement-mediated cytolysis / M.S. Sandrin [et al.] // Nat. Med. - 1995. - Vol. 1. - P. 1261-1267.

Long-term acceptance of skin and cardiac allografts after blocking CD40 and CD28 pathways / C.P. Larsen [et al.] // Nature. - 1996. - Vol. 381. - P. 434-438.

Antibody-dependent cell-mediated cytoxicity against porcine endothelium induced by a majority of human sera / A.F.M. Schaapherder [et al.] // Transplantation. - 1994. - Vol. 57. - P. 1376-1382.

Yamada, K. Human anti-porcine xenogeneic T cell response. Evidence for allelic specificity of mixed leukocyte reaction and for both direct and indirect pathways of recognition / K. Yamada, D.H. Sachs, H. DerSimonian // J. Immunol. - 1955. - Vol. 155. - P. 5249­5256.

Gill, T.J.D. Implantation of tissue into the brain. An immunologic perspective / T.J.D. Gill, R.D. Lund // JAMA. - 1989. - Vol. 261. - P. 2674-2676.

Tze, W.J. Successfull intracerebral allotransplantation of pancreatic endocrine cells in spontaneous diabetic BB rats without immunosupression / W.J. Tze // Metabolism. - 1994. - Vol. 33. - P. 785.

Dinsmore, J.H. Immunoprivileged sites for allo- and xenotransplantation. In: Cooper, D. K. C., ed. Xenotransplantation New York: Springer Verlag; 1998.

Edge, A.S.B. Xenotransplantation in the central nervous system / A.S.B. Edge, J. Dinsmore // Xenotransplantation. - 1997. - Vol. 5. - P. 23-25.

Pakzaban, P. Neural xenotransplantation: Reconstruction of neuronal circuitry across species barriers / P. Pakzaban, O. Isacson // Neuroscience. - 1994. - Vol. 62. - P. 989-1001.

Fetal porcine ventral mesencephalic transplantation for Parkinson's Disease: Preliminary results / S.A. Ellias [et al.] // Move. Disord. - 1997. - Vol. 12. - P. 839-840.

Streilein, J.W. Unraveling immune privilege / J.W. Streilein // Science. - 1995. - Vol. 270. - P. 1158-1159.

Fas ligand-induced apoptosis as a mechanism of immune privilege [see comments] / T.S. Griffith [et al.] // Science. - 1995. - Vol. 270. - P. 1189-1192.

The testis-derived cultured Sertoli cell as a natural Fas-L secreting cell for immunosuppressive cellular therapy / P.R. Sanberg [et al.] // Cell Transplant. - 1997. - Vol. 7. - P. 191-193.

. Microcarrier enhanced survival of human and rat fetal ventral mesencephalon cells implanted in the rat striatum / S. Saporta [et al.] // Cell Transplant. - 1997. - Vol. 6. - P. 579-584.

Transgenic expression of CD95 ligand on islet beta cells induces a granulocytic infiltration but does not confer immune privilege upon islet allografts / J. Allison [et al.] // Proc. Natl. Acad. Sci. USA. - 1997. - Vol. 94. - P. 3943-3947.

FAS ligand expression in Islets of Langerhans does not confer immune privilege and instead targets them for rapid destruction / S.M. Kang [et al.] // Nat. Med. - 1997. - Vol. 3. - P. 738-743.

Adenovirus-mediated expression of FAS ligand induces hepatic apoptosis after systemic administration and apoptosis of ex-vivo infected pancreatic islet allografts and isograffts / D.A. Muruve [et al.] // Hum. Gene Ther. - 1997. - Vol. 8. - P. 955-963.

Improved graft survival and striatal reinnervation by microtransplantation of fetal nigral cell suspensions in the rat Parkinson model / G. Nikkhah [et al.] // Brain Res. - 1994. - Vol. 633. - P. 133-143.

Inhibition of transplant rejection by pretreatment of xenogeneic pancreatic islet cells with anti-ICAM-1 antibodies / Y. Zeng [et al.] // Transplantation. - 1994. - Vol. 58. - P. 681-689.

Bluestone, J.A. New perspectives of CD28-B7-mediated T cell costimulation / J.A. Bluestone // Immunity. - 1 995 . - Vol. 2. - P. 555-559.

CTLA4-Ig and anti-CD40 ligand prevent renal allograft rejection in primates / A.D. Kirk [et al.] // Proc. Natl. Acad. Sci. USA. - 1997. - Vol. 94. - P. 8789-8794.

Sun, J. Interaction between CD8 and major histocompatibility complex (MHC) class I mediated by multiple contact surfaces that include the alpha-2 and alpha-3 domains of MHC class I / J. Sun, D.J. Leahy, P.B. Kavathas // J. Exp. Med. - 1995. - Vol. 182. - P. 1275­1280.

Prolonged acceptance of concordant and discordant xenografts with combined CD40 and CD28 pathway blockade / E.T. Elwood [et al.] // Transplantation. - 1998. - Vol. 65. - P. 1422­1428.

Constant, S.L. Induction of Th1 and Th2 CD41 T cell responses: The alternative approaches / S.L. Constant, K. Bottomly // Annu. Rev. Immunol. - 1997. - Vol. 15. - P. 297-322.

. An altered peptide ligand mediates immune deviation and prevents autoimmune encephalomyelitis / L.B. Nicholson [et al.] // Immunity. - 1995. - Vol. 3. - P. 397-405.

Sloan-Lancaster, J. Induction of T-cell anergy by altered T-cell-receptor ligand on live antigen-presenting cells / J. Sloan- Lancaster, B.D. Evavold, P.M. Allen // Nature. - 1993. - Vol. 363. - P. 156-159.

Inhibition of T cell activation by a monoclonal antibody reactive against the a3 domain of human MHC class I molecules / D.M. Smith [et al.] // J. Immunol. - 1994. - Vol. 153. - P. 1054.

Modulation of MHC class I antigen decreases pancreatic islet immunogenicity / P.G. Stock [et al.] // J. Surg. Res. - 1989. - Vol. 46. - P. 317-321.

Human natural killer cells account for non-MHC class I restricted cytolysis of porcine cells / C.E. Donnelly [et al.] // Cell. Immunol. - 1997. - Vol. 175. - P. 171-178.

Transplantation tolerance induced by CTLA4-Ig / T.C. Pearson [et al.] // Transplantation. - 1994. - Vol. 57. - P. 1701­1 706.

Raulet, D.H. Natural killer cell receptor: The offs and ons of NK cell recognition / D.H. Raulet, W. Held // Cell. - 1995. - Vol. 82. - P. 697-700.

Analysis of polymorphism in porcine MHC class I genes. Alterations in signals recognized by human cytotoxic lymphocytes / J.A. Sullivan [et al.] // J. Immunol. - 1997. - Vol. 159. - P. 2318­2326.

Porcine repeat element DNA: In situ detection of xenotransplanted cells / H.F. Oettinger [et al.] // Cell Transplant. - 1995. - Vol. 4. - P. 253-256.

Species specific detection of porcine xenografts with a monoclonal antibody against a novel epitope of the lymphocyte homing receptor CD44 / H.F. Oettinger [et al.] // Xenotransplantation. - 1997. - Vol. 4. - P. 252-261.

Transplantation of fetal porcine striatal cells in Huntington's disease: Preliminary safety and efficacy results / M. St. Hillaire [et al.] // Neurology. - 1998. - Vol. 50(Suppl. 4). - S10.008.

Gouras, P. Retinal cell transplantation in the macula: New techniques / P. Gouras, P. Algvere // Vision Res. - 1996. - Vol. 36. - P. 4121-4125.

Isacson, O. Neural transplantation studies reveal the brain's capacity for continuous reconstruction / O. Isacson, T. Deacon // Trends Neurosci. - 1997. - Vol. 20. - P. 477-482.

Аллотрансплантация макроинкапсулированных парати- реоцитов в лечении послеоперационного гипопаратиреоза: кли­ническое наблюдение / В.Я. Хрыщанович [и соавт.] // Вестник трансплантологии и искусственных органов. - 2011. - № 4. - С. 60-65.

Bach, F.H. Call for moratorium on xenotransplants / F.H. Bach, H.V. Fineberg // Nature. - 1998. - Vol. 391. - P. 326.

Uncertainty in xenotransplantation-individual benefit versus collective risk / F.H. Bach [et al.] // Nat. Med. - 1998. - Vol. 4. - P. 1 41 -1 44.

Two sets of human-tropic pig retrovirus / P. LeTissier [et al.] // Nature. - 1997. - Vol. 389. - P. 681-682.

Patience, C. Infection of human cells by an endogenous retrovirus of pigs / C. Patience, Y. Takeuchi, R.A. Weiss // Nat. Med. - 1997. - Vol. 3. - P. 282-286.

Weiss, R.A. Transgenic pigs and virus adaptation / R.A. Weiss // Nature. - 1998. - Vol. 391. - P. 327-328.

Identification of a full-length cDNA for an endogenous retrovirus of miniature swine / D.E. Akiyoshi [et al.] // J. Virol. - 1998. - Vol. 72. - P. 4503-4507.

. Expression of pig endogenous retrovirus by primary porcine endothelial cells and infection of human cells / U. Martin [et al.] // Lancet. - 1998. - Vol. 352. - P. 692-694.

Type C retrovirus released from porcine primary peripheral blood mononuclear cells infects human cells / C.A. Wilson [et al.] // J. Virol. - 1998. - Vol. 72. - P. 3082-3087.

Xenotransplantation and xenogeneic infections / L. Chapman [et al.] // N. Engl. J. Med. - 1995. - Vol. 333. - P. 1498-1501.

. P ri mary p are nte ral trans mi s s i o n of bovine spongi form encephalopathy to the pig / M. Dawson [et al.] // Vet. Rec. - 1990. - Vol. 127 (13). - P. 338.

Pruisner, S.B. The prion diseases / S.B. Pruisner // Sci. Am. - 1995. - Vol. 272 (1). - P. 48-57.

Pruisner, S.B. Prion diseases and neurodegeneration / S.B. Pruisner, S.J. DeArmond // Annu. Rev. Neurosci. - 1994. - Vol. 17. - P. 311-339.

No evidence of infection with porcine endogenous retrovirus in recipients of porcine islet-cell xenografts / W. Heheine [et al.] // Lancet. - 1998. - Vol. 352. - P. 695-699.

Treatment of hepatic failure with ex-vivo pig-liver perfusion followed by liver transplantation / R.S. Chari [et al.] // N. Engl. J. Med. - 1994. - Vol. 331. - P. 234-237.

No evidence of pig DNA or retroviral infection in patients with short-term extracorporeal connection to pig kidneys / C. Patience [et al.] // Lancet. 1998. - Vol. 352. - P. 699-701.




Загрузок PDF: 205
Опубликован
2015-08-07
Как цитировать
1.
Хрыщанович ВЯ, Третьяк СИ, Глинник АА. КСЕНОГЕННАЯ КЛЕТОЧНАЯ ТЕРАПИЯ: СОВРЕМЕННОЕ СОСТОЯНИЕ ПРОБЛЕМЫ И ПЕРСПЕКТИВЫ СВИНОЙ КЛЕТОЧНОЙ ТРАНСПЛАНТАЦИИ. Журнал ГрГМУ (Journal GrSMU) [Интернет]. 7 август 2015 г. [цитируется по 18 июнь 2024 г.];(1(37):14-3. доступно на: http://journal-grsmu.by/index.php/ojs/article/view/399