ГЕНЕТИЧЕСКИЕ ПРЕДПОСЫЛКИ К РАЗВИТИЮ СЕПСИСА

  • Р. Э. Якубцевич УО "Гродненский государственный медицинский университет"

Аннотация

Цель проведенного обзора литературы – обобщить результаты современных взглядов на генетические предпосылки к развитию сепсиса. Проанализировано 28 русскоязычных и англоязычных источников. Внимание уделено разным типам однонуклеотидных полиморфизмов, наличие которых способствует развитию сепсиса. Результаты приведенных исследований свидетельствуют о существовании взаимосвязи генетического полиморфизма каждого человека и риска развития септического процесса, его тяжести и исхода. На основании информации о генетических особенностях каждого человека станут возможны индивидуальные подходы к лечению и профилактике сепсиса.

Литература

Rhodes A, Evans LE, Alhazzani W, Levy MM, Antonelli M, Ferrer R, Kumar A, Sevransky JE, Sprung CL, Nunnally ME, Rochwerg B, Rubenfeld GD, Angus DC, Annane D, Beale RJ, Bellinghan GJ, Bernard GR, Chiche JD, Coopersmith C, De Backer DP, French CJ, Fujishima S, Gerlach H, Hidalgo JL, Hollenberg SM. Surviving sepsis campaign: international guidelines for management of sepsis and septic shock. Intensive Care Medicine. 2017;43(3):304-377. doi: 10.1007/s00134-017-4683-6.

Lewis DH, Chan DL, Pinheiro D, Armitage-Chan E, Garden OA. The immunopathology of sepsis: pathogen recognition, systemic inflammation, the compensatory anti-inflammatory response, and regulatory T cells. Journal of Veterinary Internal Medicine. 2012;26:457-482. doi: 10.1111/j.1939-1676.2012.00905.x.

Kumar V. Innate immune system in sepsis immunopathogenesis and its modulation as a future therapeutic approach [Internet]. In: Khatami M, ed. Inflammatory Diseases – Immunopathology, Clinical and Pharmacological Bases. InTech; 2012. p. 57-82. Available from: https://www.researchgate.net/publication/ 221924358_Innate_Immune_System_in_Sepsis_Immunopathogenesis_and_Its_Modulation_as_a_Future_Therapeutic_Approach. doi:10.5772/25590.

Waterer GW, Wunderink RG. Science review: Genetic variability- in the systemic inflammatory response. Critical Care Medicine. 2003;7(4):308-314. doi: 10.1186/cc2164.

Brookes AJ. The essence of SNPs. Gene. 1999;234(2):177-186.

Sergeyev SA, Strunin OV, Litasova EE. Rol geneticheskogo polimorfizma v razvitii sepsisa u detej [Role of genetic polymorphism in the development of sepsis in infants]. Patologija krovoobrashhenija i kardiohirurgija [Circulation Pathology and Cardiac Surgery]. 2013;17(4):59-62. doi: http://dx.doi.org/10.21688/1681-3472-2013-4-59-62. (Russian).

Sorensen TI, Nielsen GG, Andersen PK, Teasdale TW. Genetic and environmental influences on premature death in adult adoptees. New England Journal of Medicine. 1988;318(12):727-732. doi: 10.1056/NEJM198803243181202.

Arbour NC, Lorenz E, Schutte BC, Zabner J, Kline JN, Jones M, Frees K, Watt JL, Schwartz DA. TLR4 mutations are associated with endotoxin hyporesponsiveness in humans. Nature Genetics. 2000;25(2):187-191. doi: 10.1038/76048.

Allen AM, Obaro S, Bojang K, Awomoyi AA, Greenwood BM, Whittle HF, Sirugo G, Newport MJ. Variation in Toll-like receptor 4 and susceptibility to group a meningococcal meningitis in Gambian children. Pediatric Infectious Disease Journal. 2003;22(11):1018-1019. doi: 10.1097/01.inf.0000095431.15606.68.

Michalek J, Svetlikova P, Fedor M, Klimovic M, Klapacova L, Bartosova D, Elbl L, Hrstkova H, Hubacek JA. Bactericidal permeability increasing protein gene variants in children with sepsis. Intensive Care Medicine. 2007;33(12):2158-2164. doi: 10.1007/s00134-007-0860-3.

Xue B, Wu Y, Yin Z, Zhang H, Sun S, Yi T, Luo L. Regulation of lipopolysaccharide-induced inflammatory response by glutathione S-transferase PI in RAW264.7 cells. FEBS Letters. 2005;579(19):4081-4087. doi: 10.1016/j.febslet.2005.06.034.

Xue B, Wen C, Shi Y, Zhao D, Li C. Human NRAGE disrupts E-cadherin/beta-catenin regulated homotypic cell-cell adhesion. Biochemical and Biophysical Research Communications. 2005;336(1):247-251. doi: 10.1016/j.bbrc.2005.08.069.

Giamarellos-Bourboulis EJ, Opal SM. The role of genetics and antibodies in sepsis. Annals of Translational Medicine. 2016;4(17):328. doi: 10.21037/atm.2016.08.63.

Domínguez-Andrés J, Novakovic B, Li Y, Scicluna BP, Gresnigt MS, Arts RJ, Oosting M, Moorlag SJCFM, Groh LA, Zwaag J, Koch RM, Ter Horst R, Joosten LA, Wijmenga C, Michelucci A, van der Poll T, Kox M, Pickkers P, Kumar V, Stunnenberg H, Netea MG. The itaconate pathway is a central regulatory node linking innate immune tolerance and trained immunity. Cell Metabolism. 2018;29(1):1550-4131. doi: 10.1016/j.cmet.2018.09.003.

Nachtigall I, Tamarkin A, Tafelski S, Weimann A, Rothbart A, Heim S, Wernecke KD, Spies C. Polymorphisms of the toll-like receptor 2 and 4 genes are associated with faster progression and a more severe course of sepsis in critically ill patients. Journal of International Medical Research. 2014;42(1):93-110. doi: 10.1177/0300060513504358.

Wang H, Wei Y, Zeng Y, Qin Y, Xiong B, Qin G, Li J, Hu D, Qiu X, Sooranna SR, Pinhu L. The association of polymorphisms of TLR4 and CD14 genes with susceptibility to sepsis in a Chinese populyation. BMC Medical Genetics. 2014;15:123. doi: 10.1186/s12881-014-0123-4.

Zhang A-q, Yue C-l, Gu W, Du J, Wang H-y, Jiang J. Association between CD14 promoter-159C/T polymorphism and the risk of sepsis and mortality: a systematic review and meta-analysis PLoS One [Internet]. 2013;8(8):e71237. Available from: http://journals.plos.org/plosone/article?id=10.1371/journal.pone. 0071237. (accessed: 19.08.2018). doi:10.1371/journal.pone.0071237.

Teuffel O, Ethier MC, Beyene J, Sung L. Association between tumor necrosis factor-alpha promoter -308 A/G polymorphism and susceptibility to sepsis and sepsis mortality: a systematic review and meta-analysis. Critical Care Medicine. 2010;38(1):276-282. doi: 10.1097/CCM.0b013e3181b42af0.

Gao J-w, Zhang A-q, Pan W, Yue C-L, Zeng L, Gu W, Jiang J. Association between IL-6-174G/C polymorphism and the risk of sepsis and mortality: a systematic review and meta-analysis. PLoS One [Internet] 2015;10(3). Available from: http://journals.plos.org/plosone/article?id=10.1371/journal.pone. 0118843. (accessed: 03.03.2018). https://doi.org/10.1371/journal.pone.0118843.

Salnikova LYe, Smelaya TV, Moroz VV, Golubev AM, Lapteva NSh, Poroshenko GG, Rubanovich AV. Geneticheskaja predraspolozhennost k razvitiju ostroj vnebolnichnoj pnevmonii [Genetic Predisposition to the Development of Acute Community-Acquired Pneumonia]. Obshhaja reanimatologija [General Reanimatology]. 2010;6(1):5-10. https://doi.org/10.15360/1813-9779-2010-1-5. (Russian).

Dou XM, Cheng HJ, Meng L, Zhou LL, Ke YH, Liu LP, Li YM. Correlations between ACE single nucleotide polymorphisms and prognosis of patients with septic shock. Bioscience Reports. 2017;37(2):BSR20170145. doi: 10.1042/BSR20170145.

Retsas T, Huse K, Lazaridis L-D, Karampela N, Bauer M, Platzer M, Kolonia V, Papageorgiou E, Giamarellos-Bourboulis EJ, Dimopoulos G. Haplotypes composed of minor frequency single nucleotide polymorphisms of the TNF gene protect from progression into sepsis: A study using the new sepsis classification. International Journal of Infectious Diseases. 2018;67:102-106. doi: 10.1016/j.ijid.2017.12.008.

Wacharasint P, Nakada T-A, Boyd JH, Walley KR. Single nucleotide polymorphisms of IL-10 family members are associated with increased mortality in septic shock. In: 35th Annual Conference on Shock; At Miami Beach, Florida; 2012. p. 55. (Shock; no. 37, suppl. 1). doi: 10.1097/SHK.0b013e3182597b55.

Liu Z-L, Hu J, Xiao X-F, Peng Y, Zhao S-P, Xiao X-Z, Yang M-S. The CD40 rs1883832 Polymorphism Affects Sepsis Susceptibility and sCD40L Levels. BioMed Research International [Internet]. 2018;2018:7497314. Available from: https://www.hindawi.com/journals/bmri/2018/7497314. https://doi.org/ 10.1155/ 2018/7497314.

Grube M, Brenmoehl J, Rogler G, Hahn J, Herr W, Holler E. Donor Nucleotide-Binding Oligomerization-Containing Protein 2 (NOD2) Single Nucleotide Polymorphism 13 Is Associated with Septic Shock after Allogeneic Stem Cell Transplantation. Biology of Blood and Marrow Transplantation. 2015;21(8):1399-1404. doi: https://doi.org/10.1016/j.bbmt.2015.05.011.

Yamada T, Aoyama-Ishikawa M, Yamashita H, Fujiwara M, Usami M, Ueda T, Terashima M, Kohama K, Nakao A, Kotani J. IL18 production and IL18 promoter polymorphisms correlate with mortality in ICU patients. In Vivo. 2014;28(3):391-396.

Shao Y, He J, Chen F, Cai Y, Zhao J, Lin Y, Yin Z, Tao H, Shao X, Huang P, Yin M, Zhang W, Liu Z, Cui L. Association study between promoter polymorphisms of ADAM17 and progression of sepsis. Cellular Physiology, Biochemistry. 2016;39(4):1247-1261. doi: org/10.1159/000447830.

Jimenez-Sousa MA, Liu P, Medrano LM, Fernández-Rodríguez A, Almansa R, Gómez-Sánchez E, Rico L, Lorenzo M, Fadrique A, Tamayo E, Resino S. Association of CD14 rs2569190 polymorphism with mortality in shock septic patients who underwent major cardiac or abdominal surgery: a retrospective study. Scientific Reports. 2018;8(1):2698. doi: https://doi.org/10.1038/s41598-018-20766-7.




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Опубликован
2019-03-11
Как цитировать
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Якубцевич РЭ. ГЕНЕТИЧЕСКИЕ ПРЕДПОСЫЛКИ К РАЗВИТИЮ СЕПСИСА. Журнал ГрГМУ (Journal GrSMU) [Интернет]. 11 март 2019 г. [цитируется по 28 март 2024 г.];17(1):5-10. доступно на: http://journal-grsmu.by/index.php/ojs/article/view/2359

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